Non-Synthetic Emulsion-Based Lipid Formulations and Methods of Use
Saponin ( quillaja and yucca ) and terpenoid (mono- and di-) botanicals are used for emulsion-based lipids to produce stable nanoparticles of the active nutrients or pharmaceuticals by reducing surfactant usage (less than 5%) and by reducing particle size (less than 600 nm). Non-synthetic emulsion-based formulations enhance bioavailability and mitigate safety concerns. This nanoemulsion technology is suitable for oil-in-water ingredients including vitamin E tocotrienols, CoQ10s, curcuma terpenoids, symmetrical carotenoids, phenolics, lipid-soluble vitamins, and lipid-soluble pharmaceuticals.
1 . A method of making a lipid-soluble ingredient nanoemulsion comprising the steps of: a) mixing an active lipid-soluble ingredient and a lipid-soluble co-solvent to produce a lipid solution, b) mixing an emulsifier and an aqueous co-solvent to produce an aqueous solution, c) mixing the lipid solution and the aqueous solution together and homogenizing the two solutions under high pressure to generate emulsified particles of a lipid-soluble ingredient nanoemulsion.
2 . The method of claim 1 , wherein the emulsified particle is from 50 nm to 600 nm in diameter.
3 . The method of claim 2 , wherein the emulsified particle is from 100 nm to 400 nm in diameter.
4 . The method of claim 1 , wherein a zeta potential is calculated for the emulsified particle and the zeta potential is less than −30 mV or more than +30 mV.
5 . The method of claim 1 , wherein the aqueous solution further comprises a water-soluble natural surfactant.
6 . The method of claim 1 , wherein the emulsifier is a saponin.
7 . The method of claim 6 , wherein the saponin is selected from the group consisting of quillaja, yucca , and soy.
8 . The method of claim 1 , wherein the active lipid-soluble ingredient is selected from the group consisting of vitamin E, CoQ10, curcuma terpenoid, symmetrical carotenoid, omega-3, phenolics, vitamin A, vitamin D, vitamin K, and lipid-soluble pharmaceuticals.
9 . The method of claim 8 , wherein the vitamin E is selected from the group consisting of tocotrienol and tocopherol.
10 . The method of claim 9 , wherein the tocotrienol is selected from the plant source consisting of annatto, palm, and rice.
11 . The method of claim 8 , wherein the CoQ10 is selected from the group consisting of ubiquinol and ubiquinone.
12 . The method of claim 8 , wherein the curcuma terpenoid is selected from the group consisting of xanthorrhizol, tumerones, curcumenes, and curcumins.
13 . The method of claim 8 , wherein the symmetrical carotenoid is selected from the group consisting of astaxanthin, zeaxanthin, lycopene, and beta-carotene.
14 . The method of claim 8 , wherein the omega-3 is selected from the group consisting of DHA and EPA.
15 . The method of claim 8 , wherein the phenolics is selected from the group consisting of policosanol, resveratrol, EGCG, and quercetin.
16 . The method of claim 1 , wherein the lipid-soluble co-solvent is a viscosity reducer.
17 . The method of claim 16 , wherein the viscosity reducer is a natural terpenoid.
18 . The method of claim 16 , wherein the natural terpenoid is selected from the group consisting of limonene, farnesol, geranylgeraniol and essential oil.
19 . The method of claim 1 , wherein the aqueous co-solvent is a natural alcohol.
20 . The method of claim 19 , wherein the natural alcohol is selected from the group consisting of ethanol and glycerol.