Arylamide compounds and compositions and uses thereof
The present invention discloses ophthalmic and otic compositions of facially amphiphilic antimicrobial polymers and oligomers and their uses, including their use in methods for treating and preventing ophthalmic infections and otic infections in humans and animals.
1. A pharmaceutical composition comprising a compound having the formula:
or a pharmaceutically acceptable salt thereof, and water.
2. The composition of claim 1 further comprising Tris-buffered saline.
3. The composition of claim 1 further comprising Farnesol, polyethylene glycol, and Tris-buffered saline.
4. The composition of claim 1 further comprising an additional medicament.
5. The composition of claim 4 wherein the additional medicament is chosen from an antibiotic, an anti-inflammatory agent, an anesthetic agent, an anti-allergic agent, an acetylcholine blocking agent, an adrenergic agonist, a beta-adrenergic blocking agent, an anti-glaucoma agent, and an anti-hypertensive agent.
6. The composition of claim 5 wherein the anti-inflammatory agent is a steroidal agent or a non-steroidal agent.
7. The composition of claim 6 wherein the steroidal agent is chosen from dexamethasone, rimexolone, prednisolone, fluorometholone, and hydrocortisone, and wherein the non-steroidal agent is chosen from a cyclooxygenase type I or type II inhibitor, a PAF antagonist, a PDE IV inhibitor, and an inhibitor of cytokine production.
8. The composition of claim 5 wherein the anti-allergic agent is a corticosteroid.
9. The composition of claim 8 wherein the corticosteroid is chosen from prednisolone, fluorometholone, loteprenol, and dexamethasone.
10. The composition of claim 1 wherein the pharmaceutically acceptable salt is a hydrochloride acid addition salt.