PARTICLE-CONTAINING MEMBRANE AND PARTICULATE ELECTRODE FOR ANALYTE SENSORS
Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.
1 - 20 . (canceled)
21 . A system for measuring an analyte concentration in a host, the system comprising:
a working electrode configured to be implanted in a host, wherein the electrode comprises rhodium;
a membrane disposed over the electrode, wherein the membrane comprises an enzyme; and
sensor electronics configured to generate a signal indicative of a concentration of the species in the host.
22 . The system of claim 21 , wherein the sensor electronics are configured to apply a potential of from about 0.1V to about 0.8V is applied to the working electrode.
23 . The system of claim 22 , wherein the sensor electronics are configured to apply a potential of from about 0.3V to about 0.7V to the working electrode.
24 . The system of claim 23 , wherein the sensor electronics are configured to apply a potential of from about 0.3V to about 0.5V to the working electrode.
25 . The system of claim 24 , wherein the potential applied is constant.
26 . The system of claim 22 , wherein potential applied is cyclical, pulsed, intermittent, variable, or a combination thereof.
27 . The system of claim 21 , wherein the membrane comprises polyurethane.
28 . The system of claim 21 , where the analyte is glucose.
29 . The system of claim 21 , wherein the analyte is lactate.
30 . The system of claim 21 , wherein the enzyme is glucose oxidase.
31 . The system of claim 21 , wherein the working electrode comprises conductive particles that form a network and function as an array of microelectrodes.
32 . The system of claim 21 , wherein the rhodium is disposed on a substrate.
33 . The system of claim 32 , wherein the substrate is formed of a metal.
34 . The system of claim 33 , wherein the metal is platinum.
35 . The system of claim 32 , wherein the substrate is formed of a dielectric material.
36 . The system of claim 35 , wherein the dielectric material is a polymer.