Rapid production of droplets
The present invention generally relates to the production of fluidic droplets. Certain aspects of the invention are generally directed to systems and methods for creating droplets by flowing a fluid from a first channel to a second channel through a plurality of side channels. The fluid exiting the side channels into the second channel may form a plurality of droplets, and in some embodiments, at very high droplet production rates. In addition, in some aspects, double or higher-order multiple emulsions may also be formed. In some embodiments, this may be achieved by forming multiple emulsions through a direct, synchronized production method and/or through the formation of a single emulsion that is collected and re-injected into a second microfluidic device to form double emulsions.
1. An apparatus, comprising:
a first microfluidic channel;
a second microfluidic channel; and
at least five side microfluidic channels each connecting the first microfluidic channel with the second microfluidic channel, wherein the first microfluidic channel has a cross-sectional area at least 20 times greater than the smallest cross-sectional area of the at least five side channels.
2. The apparatus of claim 1 , wherein each of the at least five side channels has a length of between 90% and 110% of an average length of the side channels.
3. The apparatus of claim 1 , wherein the first microfluidic channel and the second microfluidic channel have a distance of separation that is between 90% and 110% of an average distance of separation.
4. The apparatus of claim 1 , wherein the at least five side channels are positioned such that the distance of separation between any neighboring side channels is between 90% and 110% of an average distance of separation between neighboring side channels.
5. The apparatus of claim 4 , wherein the at least five side channels have a periodic spacing that is between 25% and 400% of a smallest cross-sectional dimension of the at least five side channels.
6. The apparatus of claim 1 , wherein the at least five side channels have a periodic spacing that is between 90% and 110% of a smallest cross-sectional dimension of the at least five side channels.
7. The apparatus of claim 1 , wherein the at least five side channels each connecting the first microfluidic channel with the second microfluidic channel are arranged in a linear configuration.
8. The apparatus of claim 1 , wherein the smallest cross-sectional area of the at least five side channels is less than 500 micrometers 2 .
9. The apparatus of claim 1 , wherein the smallest cross-sectional area of the at least five side channels is less than 100 micrometers 2 .
10. The apparatus of claim 1 , wherein each of the at least five side channels has a cross-sectional area of between 90% and 110% of an average cross-sectional area of the side channels.
11. The apparatus of claim 1 , wherein each of the at least five side channels has a volume of between 90% and 110% of an average volume of the side channels.
12. The apparatus of claim 1 , wherein the first microfluidic channel has a length of at least 1 mm.
13. The apparatus of claim 1 , wherein the first microfluidic channel has a cross-sectional area that varies between 90% and 110% of an average cross-sectional area.
14. The apparatus of claim 1 , wherein the second microfluidic channel has a cross-sectional area that varies between 90% and 110% of an average cross-sectional area.
15. The apparatus of claim 1 , wherein the second microfluidic channel comprises a droplet.
16. An apparatus, comprising:
a first microfluidic channel having a length of at least 5 mm;
a second microfluidic channel parallel to the first microfluidic channel; and
at least five side microfluidic channels each connecting the first microfluidic channel with the second microfluidic channel.
17. The apparatus of claim 16 , wherein the second microfluidic channel comprises a droplet.
18. A method, comprising:
flowing a first fluid in a first microfluidic channel through at least five side microfluidic channels into a second fluid contained in a second microfluidic channel,
wherein the first fluid forms a plurality of droplets within the second microfluidic channel, the droplets each having a characteristic dimension of between 90% and 110% of an average characteristic dimension of the plurality of droplets.
19. The method of claim 18 , wherein the plurality of droplets has a coefficient of variation of less than 20%.
20. The method of claim 18 , comprising forming droplets at a rate of at least 1,000 droplets per second.
21. The method of claim 18 , wherein the plurality of droplets has an average characteristic dimension of less than 1000 micrometers.
22. The method of claim 18 , wherein the plurality of droplets formed within the second microfluidic channel are contained within a second fluid.