Aerostasis in pulmonary surgery
A device for use in pulmonary surgery is presented. The device includes a dispensing apparatus 300, 400, 900 , a delivery apparatus 100, 1000, 1100 , in fluid communication with said dispensing apparatus, and a pressurized gas input 338 . The dispensing apparatus is configured to provide a pressurized gas, a fibrinogen stream, and a thrombin stream to the delivery apparatus. The delivery apparatus is configured to mix the fibrogen stream and the thrombin stream in the pressurized gas stream to form a fibrin reaction mixture comprising a cellular foam 700.
1. A method for preventing air leaks from a serosal tissue wound, comprising:
providing a device comprising a dispensing apparatus and a delivery apparatus in fluid communication with said dispensing apparatus;
rapidly warming frozen aliquots of fibrinogen and thrombin from about 0° C. to about 37° C. in about 3 minutes or less;
after fibrinogen aliquots and thrombin aliquots are rapidly warmed to about 37° C., the fibrinogen and thrombin aliquots are provided within about 5 minutes from said dispensing apparatus to said delivery apparatus;
mixing a fibrinogen stream and a thrombin stream in a pressurized gas stream, said pressurized gas stream having a pressure of 50 psi or greater;
generating a fibrin-forming foam; and
directing said fibrin-forming foam onto said serosal tissue wound.
2. The method of claim 1 , wherein said pressurized gas stream is integral with said dispensing apparatus.
3. The method of claim 2 , wherein said dispensing apparatus comprises a pneumatic plunger.
4. The method of claim 2 , wherein said dispensing apparatus comprises a pressure regulator in fluid communication with said pressurized gas stream.
5. The method of claim 1 , further comprising:
coupling a fibrinogen input of said delivery apparatus to a fibrinogen output of said dispensing apparatus;
coupling a thrombin input of said delivery apparatus to a thrombin output of said dispensing apparatus; and
coupling a pressurized gas input of said delivery apparatus to a pressurized gas output of said dispensing apparatus.
6. The method of claim 1 , wherein said delivery apparatus comprises a turbulent mixing assembly, said method further comprising generating in said turbulent mixing assembly a flow of a thrombin/fibrinogen reaction mixture having a Reynolds number greater than 5000.
7. The method of claim 6 , wherein said turbulent mixing assembly is formed to include a plurality of inwardly extending dimples.
8. The method of claim 7 , wherein said plurality of inwardly extending dimples are formed in opposing pairs on said turbulent mixing assembly.
9. The method of claim 1 , wherein:
said delivery apparatus further comprises a venturi assembly in fluid communication with a turbulent mixing assembly;
said venturi assembly comprises a tubular structure having an outer surface and a lumen extending therethrough;
said venturi assembly is formed to include a plurality of air passages extending from said outer surface to said lumen; and
said method further comprises initiating turbulent mixing of said thrombin stream and said fibrinogen stream in said venturi assembly.
10. The method of claim 9 , wherein said plurality of air passages are formed in opposing pairs in said venturi assembly.