Stabilized hypochlorous acid solution and use thereof
Disclosed is an antimicrobial solution comprising, consisting essentially of or consisting of (a) hypochlorous acid, (b) a divalent cation, (c) phosphate anion, and (d) water, as well as a process for its production. Also disclosed is a method of treating or preventing infection associated with abdominal surgery on a mammal, comprising use of the antimicrobial solution.
1. An antimicrobial solution, wherein the solution consists of:
(a) about 10 mg/L to about 500 mg/L of hypochlorous acid,
(b) magnesium sulfate in an amount sufficient to provide about 20 mg/L to about 250 mg/L of magnesium,
(c) sodium dihydrogen phosphate in an amount sufficient to provide about 200 mg/L to about 1000 mg/L of phosphate anion formulated as PO 4 2− ,
(d) chloride ion, and
(e) water,
wherein the solution has a pH of about 4.5 to about 5.5.
2. A process for the production of an antimicrobial solution comprising the steps of:
(i) providing a mixture consisting of (a) magnesium sulfate (b) sodium dihydrogen phosphate, (c) a pH-adjusting agent, and (d) water, and
(ii) adding chlorine gas to the mixture,
wherein the process produces a solution consisting of hypochlorous acid in an amount from about 10 mg/L to about 500 mg/L, magnesium sulfate in an amount sufficient to provide about 20 mg/L to about 250 mg/L of magnesium, sodium dihydrogen phosphate is present in an amount sufficient to provide about 200 mg/L to about 1000 mg/L of phosphate anion formulated as PO 4 2− , and chloride ion, and having a pH from about 3 to about 7.
3. The process of claim 2 , wherein hypochlorous acid is present in the solution in an amount from about 50 mg/L to about 250 mg/L.
4. The process of claim 2 , wherein chloride ion is present in the solution in an amount from about 20 mg/L to about 100 mg/L.
5. The process of claim 2 , wherein the chlorine gas is bubbled into the mixture.
6. A process for the production of an antimicrobial solution comprising the steps of:
(i) providing a mixture consisting of hypochlorous acid and water,
(ii) adding (a) magnesium sulfate, (b) sodium dihydrogen phosphate, and (c) a pH-adjusting agent to the mixture, and
(iii) adding chloride ion to the mixture,
wherein the process produces a solution consisting of hypochlorous acid in an amount from about 10 mg/L to about 500 mg/L, magnesium sulfate in an amount sufficient to provide about 20 mg/L to about 250 mg/L of magnesium, sodium dihydrogen phosphate is present in an amount sufficient to provide about 200 mg/L to about 1000 mg/L of phosphate anion formulated as PO 4 2− , and chloride ion, and having a pH from about 3 to about 7.
7. The process of claim 6 , wherein the hypochlorous acid is electrochemically generated.
8. The process of claim 6 , wherein hypochlorous acid is present in the solution in an amount from about 50 mg/L to about 250 mg/L.
9. The process of claim 6 , wherein chloride ion is present in the solution in an amount from about 20 mg/L to about 100 mg/L.
10. A method of treating or preventing infection associated with abdominal surgery on a mammal, comprising administering to the mammal an effective amount of the solution of claim 1 .
11. The method of claim 10 , wherein the surgery is inguinal hernia surgery, exploratory laparotomy, appendectomy, or laparoscopy.
12. The method of claim 10 , wherein the infection is caused by an organism selected from methicillin-resistant S. aureus, E. coli, P. aeruginosa , Vancomycin-resistant Enterococcus, P. mirabilis, S. marcescens , and C. albicans.
13. The solution of claim 1 , wherein chloride ion is present in the solution in an amount from about 20 mg/L to about 100 mg/L.