Polymer coated particles and methods thereof
View Patent ↗Embodiments of the presently-disclosed subject matter include a composition that comprises a particle, a plurality of surface functional groups on a surface of the particle, and a plurality of coating polymers bound to the surface functional groups and forming a coating on the particle that includes a density ratio of about 0.1 to about 20.0, the density ratio being equal to a Flory radius of the plurality of coating polymers divided by a distance between adjacent surface functional groups. Embodiments of the presently-disclosed subject matter also include methods for making the present compositions as well as methods for using the present compositions to deliver a bioactive agent and treat a subject in need thereof.
1. A composition, comprising:
a particle;
a plurality of surface functional groups on a surface of the particle; and
a plurality of coating polymers bound to the surface functional groups and forming a coating on the particle that includes a density ratio of about 1.0 to about 20.0, the density ratio being equal to a Flory radius of the plurality of coating polymers divided by a distance between adjacent surface functional groups;
wherein the surface functional groups are selected from the group consisting of carboxyl, amine, aldehyde, acetal, thiol, acrylate, isocyanate, maleimide, hydroxyl, halogen, electrostatically charged functional groups, and combinations thereof.
2. The composition of claim 1 , wherein the density ratio is about 2.8 to about 10.0.
3. The composition of claim 1 , wherein the particle is a nanoparticle, a microparticle, or a combination thereof.
4. The composition of claim 3 , wherein the particle having a diameter of about 5 nm to about 500 nm.
5. The composition of claim 1 , wherein the particle is comprised of a polymer.
6. The composition of claim 1 , wherein the particle is polystyrene, silica, or combinations thereof.
7. The composition of claim 1 , wherein the plurality of coating polymers is a hydrophilic polymer.
8. The composition of claim 7 , wherein the hydrophilic polymer is poly(ethylene glycol) (PEG).
9. The composition of claim 1 , wherein the plurality of coating polymers have a molecular weight of about 100 g/mol to about 20,000 g/mol.
10. The composition of claim 9 , wherein the plurality of coating polymers have a molecular weight of about 100 g/mol to about 5,000 g/mol.
11. The composition of claim 1 , wherein the plurality of coating polymers is a functional group that can react and form a bond with the surface functional groups.
12. The composition of claim 11 , wherein the functional groups on the plurality of coating polymers are selected from carboxyl, amine, aldehyde, acetal, thiol, acrylate, isocyanate, maleimide, hydroxyl, halogen, and combinations thereof.
13. The composition of claim 11 , wherein the functional groups on the plurality of coating polymers are on a terminal end of the coating polymers.
14. The composition of claim 1 , wherein the surface functional groups are selected from carboxyl, amine, aldehyde, acetal, thiol, acrylate, isocyanate, maleimide, hydroxyl, halogen, and combinations thereof.
15. The composition of claim 1 , wherein the particle further comprises a bioactive agent.
16. The composition of claim 1 , wherein the composition comprises a plurality of the particles.
17. A method for making a particle, comprising:
providing a particle that includes surface functional groups on the surface of the particle; and
contacting the surface functional groups of the particle with a plurality of coating polymers to form a coating on the particle that includes a density ratio of about 1.0 to about 20.0, the density ratio being equal to a Flory radius of the plurality of coating polymers divided by a distance between adjacent surface functional groups;
wherein the surface functional groups are selected from the group consisting of carboxyl, amine, aldehyde, acetal, thiol, acrylate, isocyanate, maleimide, hydroxyl, halogen, electrostatically charged functional groups, and combinations thereof.