Chemical structures for localized delivery of therapeutic agents
The present invention provides a method for selective delivery of a therapeutic or diagnostic agent to a targeted organ or tissue by implanting a biocompatible solid support in the patient being linked to a first binding agent, and administering a second binding agent to the patient linked to the therapeutic or diagnostic agent, such that the therapeutic or diagnostic agent accumulates at the targeted organ or tissue.
1. A composition comprising:
an implantable biocompatible solid support selected from the group consisting of polysaccharide hydrogels, alginate, cellulose, hyaluronic acid, chitosan, chitin, chondroitin sulfate, heparin, a polymer matrix, a metal, a ceramic and a plastic;
at least one binding agent linked to the biocompatible solid support, wherein the at least one binding agent is capable of a bioorthogonal reaction with a corresponding binding agent and the bioorthogonal reaction is between a trans-cyclooctene and a tetrazine; and
a linker covalently linking each binding agent to the implantable biocompatible solid support.
2. The composition of claim 1 , wherein the implantable biocompatible solid support comprises alginate.
3. The composition of claim 1 , wherein the composition has the structure of the formula:
4. The composition of claim 1 , wherein the implantable biocompatible solid support is selected from the group consisting of alginate, chitin, hyaluronic acid and chitosan.
5. The composition of claim 4 , wherein the implantable biocompatible solid support is hyaluronic acid.
6. The composition of claim 1 , wherein the composition is formulated in a sterile injectable preparation.
7. The composition of claim 1 , wherein the at least one binding agent comprises trans-cyclooctene or tetrazine.
8. The composition of claim 1 , wherein the at least one binding agent is trans-cyclooctene or tetrazine.
9. The composition of claim 1 , wherein the implantable biocompatible solid support comprises the polymer matrix.