Bioreactor system with a temperature sensor

1. A bioreactor system comprising:

a base station comprising a temperature sensor means positioned in an opening on the upper surface of the base station, a control system, and a communication connection between the temperature sensor means and the control system,

wherein the temperature sensor means comprises a first side, a second side opposite the first side, a third side connecting the first and the second sides, and a temperature sensor,

wherein the first side comprises a thermally conducting layer arranged to face a surface to be measured, the second side comprises a thermally insulating layer on an opposite side of the surface to be measured, and the third side comprises a thermally insulating layer,

wherein the thermally conducting layer and the thermally insulating layer sandwich the temperature sensor therebetween, the temperature sensor being surrounded on all its other sides by the thermally insulating layer,

a tray exchangeably attached to the base station to house a bioreactor bag,

wherein the tray comprises a heater and at least one opening that substantially aligns with the opening on the upper surface of the base station for receiving the temperature sensor means such that the first side of the temperature sensor means will contact a surface of the bioreactor bag when the bioreactor bag is provided in the tray, and

wherein the opening in the tray is larger than the temperature sensor means such that the temperature sensor is less affected by the heater provided in the tray.

2. The bioreactor system of claim 1 , wherein the temperature sensor is mounted on one end of an arm being a lever with the other end of the arm connected to a pushing device provided on the tray such that when the pushing device is pushed down by a force independent of the bioreactor bag, the temperature sensor will move upwards through the opening in the tray such that the temperature sensor will contact the bioreactor bag surface but not disturb the bioreactor bag surface.

3. The bioreactor system of claim 1 , wherein the base station comprises more than one temperature sensors each positioned in an opening on the upper surface of the base station and the opening(s) in the tray that align with the opening(s) in the base station allows the temperature sensor(s) positioned therein to contact the bioreactor bag surface, whereby the other temperature sensor(s) optionally will be blocked by the tray and not contact the bioreactor bag surface.

4. The bioreactor system of claim 3 , wherein each temperature sensor is mounted on a separate arm.

5. The bioreactor system of claim 1 , wherein the control system comprises a device for compensating the temperature measurement for the ambient temperature.

6. The bioreactor system of claim 1 , wherein

the bioreactor system is calibrated and only the base station and not the tray holding the bioreactor bag is considered for calibration.

7. The bioreactor system of claim 1 , wherein the thermally conducting layer is a material having higher thermal conductivity than the thermally insulating layer.

8. The bioreactor system of claim 1 , wherein the thermally conducting layer is a metal or a thermally conducting graphite or polymer.

9. The bioreactor system of claim 1 , wherein the base station comprises three temperature sensors each positioned in an opening on the upper surface of the base station and the tray comprises two openings align with two of the three openings of the base station such that the two temperature sensors positioned therein can protrude and respectively contacting the surface of two bioreactor bags, whereby the third temperature sensor will be blocked by the tray and not contacting the surface of any bioreactor bags.

10. The bioreactor system of claim 1 , wherein the tray comprises two openings to receive one temperature sensor each.

11. The bioreactor system of claim 1 , wherein two bioreactor bags are provided that each in contact with one temperature sensor.

12. The bioreactor system of claim 1 , wherein there are three temperature sensors and the tray comprises one opening to receive one of the three temperature sensors.