Granted Patent
B2
US 12,504,355 · App. 17/015,678 · Granted Dec 23, 2025
Thawing biological substances
Assignee:
FreMon Scientific, Inc.
G01N1/44A01N1/146A61J1/10A61J1/16A61J1/18A61M1/0281A61M5/445B01F31/23B01F35/92H05B1/025H05B3/06A61J2200/42A61J2200/70A61J2200/72A61J2200/74A61J2205/60A61M1/025A61M2205/3368A61M2205/3393A61M2205/36A61M2205/3653A61M2205/50B01F2035/99B01F2101/2202
View Patent ↗
Loading inventors, assignments & file history…
Abstract
Dry thawing systems and devices for thawing biological substances are provided herein. Methods for thawing biological substances are also provided.
Claims (19)
1 . An overwrap bag to contain a biological substance container and to be placed in a thawing system comprising a housing and a chamber frame configured to receive the biological substance container contained in the overwrap bag, the overwrap bag comprising:
a flexible or semi-rigid cavity sized to be sized to be received in the chamber frame, flexible or semi-rigid cavity including a pre-formed funnel-shaped portion configured to receive and align the biological substance container, wherein the biological substance container is configured to contain from about 3 mL to about 10 mL of a biological substance, wherein the pre-formed funnel-shaped cavity comprises a top portion with a first width and a substantially straight stem portion having a bottom portion opposite the top portion with a second width smaller than the first width and larger than the width of the biological substance container, such that the biological substance container passing the top portion is funneled toward the bottom portion and aligned by the substantially straight stem portion with respect to the second width;
a temperature sensor coupled to a portion of the flexible or semi-rigid cavity and positioned in between the top portion and the bottom portion and within the second width, with respect to the pre-formed funnel-shaped portion, and configured to measure a temperature of the biological substance container containing the biological substance, wherein the substantially straight stem portion is configured to align the biological substance with respect to the temperature sensor; and
an identifier for the biological substance,
wherein the pre-formed funnel-shaped cavity is shaped to funnel the biological substance container toward the bottom portion, with the substantially straight stem portion aligning the biological substance container to contact the portion of the cavity where the temperature sensor is coupled,
wherein the overwrap bag further comprises a cover attached to one end of the flexible or semi-rigid cavity and comprises a portion to mount the overwrap bag to the chamber frame.
2 . The bag of claim 1 , wherein the temperature sensor is positioned on an inner surface of the bag.
3 . The bag of claim 1 further comprising an insulator opposing the temperature sensor and positioned on an outer surface of the bag.
4 . The bag of claim 1 , wherein the identifier is mounted to a surface of the bag.
5 . The bag of claim 1 , wherein the identifier comprises an RFID tag.
6 . The bag of claim 1 , wherein the temperature sensor is integrated with the identifier.
7 . The bag of claim 1 , wherein the identifier is configured to overlie a portion of the pre-formed funnel-shaped cavity configured to hold the container containing the biological substance during thawing.
8 . The bag of claim 1 further comprising a cover configured to reversibly seal an end of the bag.
9 . The bag of claim 8 , wherein the cover comprises one or more of a groove, a ridge, a reversible adhesive, a magnetic-based closure, and a hook.
10 . The bag of claim 8 , wherein the cover is configured to support the bag when placed within a thawing device.
11 . The bag of claim 1 , wherein the bag comprises a thermally conductive material configured to withstand temperatures between about −196° C. and about 40° C.
12 . The bag of claim 1 , wherein the bag is reversibly sealable.
13 . The bag of claim 1 , wherein the bag is configured for a single use.
14 . The bag of claim 1 , wherein the biological substance comprises one or more of whole blood, blood products, plasma derivatives, breast milk, ovaries, eggs, sperm, embryos, tissue, drugs, molecular reagents, antibodies, and cells.
Assignments (2)
SECURITY INTEREST
Recorded Mar 14, 2024
From: FREMON SCIENTIFIC, INC.
To: BOYD BIOMEDICAL, INC.
Reel/Frame 066775/0027 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 10, 2021
From: SHAVIT, MENACHEM
To: FREMON SCIENTIFIC, INC.
Reel/Frame 056190/0163 →
Continuity (3)
Provisional Application
62668034
· May 7, 2018
References Cited (317)
US 2640906A
· Haynes
· 1953
[cited by applicant]
US 3475590A
· Pins
· 1969
[cited by applicant]
US 3485245A
· Lahr et al.
· 1969
[cited by applicant]
US 3518393A
· Besseling et al.
· 1970
[cited by applicant]
US 3590215A
· Anderson et al.
· 1971
[cited by applicant]
US 3798418A
· Reik et al.
· 1974
[cited by applicant]
US 3898023A
· Faust
· 1975
[cited by applicant]
US 4309592A
· Le Boeuf
· 1982
[cited by applicant]
US 4486389A
· Darnell et al.
· 1984
[cited by applicant]
US 4680445A
· Ogawa
· 1987
[cited by applicant]
US 4731072A
· Aid
· 1988
[cited by applicant]
US 4847470A
· Bakke
· 1989
[cited by applicant]
US 4852641A
· Noble
· 1989
[cited by applicant]
US 4967061A
· Weber, Jr. et al.
· 1990
[cited by applicant]
US 5013889A
· Bakke
· 1991
[cited by applicant]
US 5081697A
· Manella
· 1992
[cited by applicant]
US 5114681A
· Bertoncini et al.
· 1992
[cited by applicant]
US 5206479A
· Zakaria et al.
· 1993
[cited by applicant]
US 5245693A
· Ford et al.
· 1993
[cited by applicant]
US 5261255A
· Coelho et al.
· 1993
[cited by applicant]
US 5297234A
· Harms et al.
· 1994
[cited by applicant]
US 5364385A
· Harms et al.
· 1994
[cited by applicant]
US 5368569A
· Sanese
· 1994
[cited by applicant]
US H1623H
· Reed et al.
· 1997
[cited by applicant]
US 5603220A
· Seaman
· 1997
[cited by applicant]
US 5616268A
· Carr
· 1997
[cited by applicant]
US 5691452A
· Gawryl et al.
· 1997
[cited by applicant]
US 5779974A
· Kuzyk
· 1998
[cited by applicant]
US 6007773A
· Kuzyk
· 1999
[cited by applicant]
US 6142974A
· Kistner et al.
· 2000
[cited by applicant]
US 6159368A
· Moring et al.
· 2000
[cited by applicant]
US 6259067B1
· Faries, Jr. et al.
· 2001
[cited by applicant]
US 6371121B1
· Faries, Jr. et al.
· 2002
[cited by applicant]
US 6381981B1
· Yaddgo et al.
· 2002
[cited by applicant]
US 6384380B1
· Faries, Jr. et al.
· 2002
[cited by applicant]
US 6419827B1
· Sandell et al.
· 2002
[cited by applicant]
US 6432320B1
· Bonsignore et al.
· 2002
[cited by applicant]
US 6452138B1
· Kochman et al.
· 2002
[cited by applicant]
US 6503457B1
· Neeper et al.
· 2003
[cited by applicant]
US 6596531B2
· Campbell et al.
· 2003
[cited by applicant]
US 6638761B2
· Shin et al.
· 2003
[cited by applicant]
US 6684646B2
· Voute et al.
· 2004
[cited by applicant]
US 6698213B2
· Voute et al.
· 2004
[cited by applicant]
US 6727480B2
· Fernando et al.
· 2004
[cited by applicant]
US 6730883B2
· Brown et al.
· 2004
[cited by applicant]
US 6748164B1
· Kuzyk
· 2004
[cited by applicant]
US 6786054B2
· Voute et al.
· 2004
[cited by applicant]
US 6824528B1
· Faries, Jr. et al.
· 2004
[cited by applicant]
US 6861624B1
· Pelster
· 2005
[cited by applicant]
US 6931864B2
· Fuhr et al.
· 2005
[cited by applicant]
US 6945056B2
· Brown et al.
· 2005
[cited by applicant]
US 6996995B2
· Voute et al.
· 2006
[cited by applicant]
US 7011797B2
· Bakke
· 2006
[cited by applicant]
US 7019267B2
· Weinfield et al.
· 2006
[cited by applicant]
US 7041941B2
· Faries, Jr. et al.
· 2006
[cited by applicant]
US 7077559B2
· Hlavinka et al.
· 2006
[cited by applicant]
US 7104074B2
· Voute et al.
· 2006
[cited by applicant]
US 7137261B2
· Brown et al.
· 2006
[cited by applicant]
US 7228688B2
· Voute et al.
· 2007
[cited by applicant]
US 7276675B2
· Faries, Jr. et al.
· 2007
[cited by applicant]
US 7278278B2
· Wowk et al.
· 2007
[cited by applicant]
US 7307245B2
· Faries, Jr. et al.
· 2007
[cited by applicant]
US 7353658B2
· Voute et al.
· 2008
[cited by applicant]
US 7433030B2
· Waldo et al.
· 2008
[cited by applicant]
US 7452510B2
· Weinfield et al.
· 2008
[cited by applicant]
US 7603921B2
· Baumfalk et al.
· 2009
[cited by applicant]
US 7618808B1
· Papp
· 2009
[cited by applicant]
US 7638100B2
· Dawes
· 2009
[cited by applicant]
US 7711251B2
· Barkey
· 2010
[cited by applicant]
US 7722839B2
· Kuzyk
· 2010
[cited by applicant]
US 7920802B2
· Minagawa
· 2011
[cited by applicant]
US 7924169B2
· Baumfalk et al.
· 2011
[cited by applicant]
US 7955840B2
· Belgrader
· 2011
[cited by applicant]
US 7958791B2
· Zimmermann et al.
· 2011
[cited by applicant]
US 8012416B2
· Kuzyk
· 2011
[cited by applicant]
US 8028532B2
· Voute et al.
· 2011
[cited by applicant]
US 8037696B2
· Shaham et al.
· 2011
[cited by applicant]
US 8070354B2
· Bungay, III et al.
· 2011
[cited by applicant]
US 8329433B2
· Belgrader
· 2012
[cited by applicant]
US 8371132B2
· Cutting et al.
· 2013
[cited by applicant]
US 8377030B2
· Hyde et al.
· 2013
[cited by applicant]
US 8448457B2
· Cutting et al.
· 2013
[cited by applicant]
US 8451138B2
· Zimmermann et al.
· 2013
[cited by applicant]
US 8539790B1
· Budd
· 2013
[cited by applicant]
US 8550703B2
· Cutting
· 2013
[cited by applicant]
US 8852536B2
· Davidowitz et al.
· 2014
[cited by applicant]
US 8863532B2
· Voute et al.
· 2014
[cited by applicant]
US 8906652B2
· Belgrader
· 2014
[cited by applicant]
US 8968232B2
· Kamen et al.
· 2015
[cited by applicant]
US 9000332B2
· Brown
· 2015
[cited by applicant]
US 9034635B2
· Termaat et al.
· 2015
[cited by applicant]
US 9046292B2
· Burke et al.
· 2015
[cited by applicant]
US 9103703B2
· Baumfalk et al.
· 2015
[cited by applicant]
US 9121403B2
· Lanigan et al.
· 2015
[cited by applicant]
US 9140487B2
· Chaffey et al.
· 2015
[cited by applicant]
US 9173248B2
· Baker
· 2015
[cited by applicant]
US RE45789E
· Shei et al.
· 2015
[cited by applicant]
US 9357763B2
· Cullis et al.
· 2016
[cited by applicant]
US 9441893B2
· Velayudhan et al.
· 2016
[cited by applicant]
US 9648970B2
· Lee
· 2017
[cited by applicant]
US 9707528B2
· Suchocki et al.
· 2017
[cited by applicant]
US 9764075B2
· Blickhan et al.
· 2017
[cited by applicant]
US 9833580B2
· Cho
· 2017
[cited by applicant]
US 9920970B2
· Arnitz et al.
· 2018
[cited by applicant]
US 9932632B2
· Kreifels et al.
· 2018
[cited by applicant]
US 20010033233A1
· Jentsch et al.
· 2001
[cited by applicant]
US 20010042743A1
· Faries, Jr. et al.
· 2001
[cited by applicant]
US 20030222100A1
· Husband
· 2003
[cited by examiner]
US 20040241835A1
· Hutmacher et al.
· 2004
[cited by applicant]
US 20050127056A1
· Petkov et al.
· 2005
[cited by applicant]
US 20070029311A1
· Akashi et al.
· 2007
[cited by applicant]
US 20070275435A1
· Kim et al.
· 2007
[cited by applicant]
US 20100075405A1
· Broadley et al.
· 2010
[cited by applicant]
US 20100291536A1
· Viljoen et al.
· 2010
[cited by applicant]
US 20110127273A1
· Deane et al.
· 2011
[cited by applicant]
US 20120330234A1
· Balluff et al.
· 2012
[cited by applicant]
US 20130091890A1
· Schryver et al.
· 2013
[cited by applicant]
US 20160010871A1
· Baker
· 2016
[cited by applicant]
US 20160095165A1
· Smith, III
· 2016
[cited by applicant]
US 20170135902A1
· Scully, Jr.
· 2017
[cited by applicant]
US 20180250666A1
· Paul et al.
· 2018
[cited by applicant]
US 20180255766A1
· Dick et al.
· 2018
[cited by applicant]
US 20180320126A1
· Doody
· 2018
[cited by applicant]
US 20180324900A1
· Shavit
· 2018
[cited by applicant]
US 20190152676A1
· Murphy
· 2019
[cited by applicant]
US 20190194593A1
· Ozaki et al.
· 2019
[cited by applicant]
US 20190329248A1
· Scherrer
· 2019
[cited by examiner]
US 20210146026A1
· Shavit
· 2021
[cited by applicant]
CN 102802693A
· 2012
[cited by applicant]
CN 105999444A
· 2016
[cited by applicant]
DE 3121280A1
· 1983
[cited by applicant]
DE 3225695A1
· 1984
[cited by applicant]
DE 3311591A1
· 1984
[cited by applicant]
DE 3321603A1
· 1984
[cited by applicant]
DE 3500614A1
· 1986
[cited by applicant]
DE 3640114A1
· 1988
[cited by applicant]
DE 3705596A1
· 1988
[cited by applicant]
DE 3723861A1
· 1989
[cited by applicant]
DE 3741051C1
· 1989
[cited by applicant]
DE 3800283A1
· 1989
[cited by applicant]
DE 3900101A1
· 1990
[cited by applicant]
DE 4316163C2
· 1995
[cited by applicant]
DE 4328321C2
· 1995
[cited by applicant]
DE 19503350C1
· 1996
[cited by applicant]
DE 4444180C2
· 1997
[cited by applicant]
DE 19841556C1
· 2000
[cited by applicant]
DE 19940715C2
· 2001
[cited by applicant]
DE 10035297A1
· 2002
[cited by applicant]
DE 10112465C1
· 2002
[cited by applicant]
DE 10238492A1
· 2004
[cited by applicant]
DE 202004017612U1
· 2005
[cited by applicant]
DE 10324116A1
· 2005
[cited by applicant]
DE 10332781A1
· 2005
[cited by applicant]
DE 102005036369A1
· 2007
[cited by applicant]
DE 202005021496U1
· 2008
[cited by applicant]
DE 102007056169A1
· 2009
[cited by applicant]
DE 102009011707A1
· 2010
[cited by applicant]
DE 102010002895A1
· 2011
[cited by applicant]
DE 102010020374A1
· 2011
[cited by applicant]
DE 202013101214U1
· 2013
[cited by applicant]
DE 202013102927U1
· 2013
[cited by applicant]
DE 112015000765A5
· 2016
[cited by applicant]
DE 102015113325A1
· 2017
[cited by applicant]
EP 0432591A1
· 1991
[cited by applicant]
EP 0318924B1
· 1992
[cited by applicant]
EP 0396729B1
· 1994
[cited by applicant]
EP 0653215A1
· 1995
[cited by applicant]
EP 0527944B1
· 1996
[cited by applicant]
EP 0786981B1
· 1998
[cited by applicant]
EP 1138304A2
· 2001
[cited by applicant]
EP 1174703A2
· 2002
[cited by applicant]
EP 0880663B1
· 2003
[cited by applicant]
EP 1426672A1
· 2004
[cited by applicant]
EP 1299138B1
· 2005
[cited by applicant]
EP 1441585B1
· 2006
[cited by applicant]
EP 1441586B1
· 2006
[cited by applicant]
EP 1747790B1
· 2007
[cited by applicant]
EP 1476013B1
· 2011
[cited by applicant]
EP 2389063B1
· 2012
[cited by applicant]
EP 2510965A1
· 2012
[cited by applicant]
EP 2547386A2
· 2013
[cited by applicant]
EP 2839822A1
· 2015
[cited by applicant]
EP 2914104A2
· 2015
[cited by applicant]
EP 2976637A1
· 2016
[cited by applicant]
EP 2442857B1
· 2016
[cited by applicant]
EP 3104917A1
· 2016
[cited by applicant]
EP 3016558B1
· 2017
[cited by applicant]
GB 952521A
· 1964
[cited by applicant]
JP 5261625B1
· 2013
[cited by applicant]
RU 2552822C1
· 2015
[cited by applicant]
WO WO8807384A1
· 1988
[cited by applicant]
WO WO9221254A1
· 1992
[cited by applicant]
WO WO9509597A1
· 1995
[cited by applicant]
WO WO0014463A1
· 2000
[cited by applicant]
WO WO2010031237A1
· 2010
[cited by applicant]
WO WO2010132627A2
· 2010
[cited by applicant]
WO WO2010132627A3
· 2010
[cited by applicant]
WO WO2011113421A2
· 2011
[cited by applicant]
WO WO2011113421A3
· 2011
[cited by applicant]
WO WO2014146641A1
· 2014
[cited by applicant]
WO WO2015000464A1
· 2015
[cited by applicant]
WO WO2015120843A1
· 2015
[cited by applicant]
WO WO2015175819A1
· 2015
[cited by applicant]
WO WO2016023034A1
· 2016
[cited by examiner]
WO WO2017025789A4
· 2017
[cited by applicant]
WO WO2018000051A1
· 2018
[cited by applicant]
WO WO2018010999A1
· 2018
[cited by applicant]
WO WO2018025053A1
· 2018
[cited by applicant]
WO WO2018195107A1
· 2018
[cited by applicant]
WO WO2018211437A1
· 2018
[cited by applicant]
Corrected Notice of Allowability mailed on Oct. 23, 2019, for U.S. Appl. No. 16/405,974, filed May 7, 2019, 2 pages.
[cited by applicant]
Corrected Notice of Allowability mailed on Jan. 14, 2020, for U.S. Appl. No. 15/502,642, filed Mar. 7, 2017, 2 pages.
[cited by applicant]
Extended European Search Report mailed on Aug. 13, 2018, for EP Application No. 15 829 831.5, filed on Aug. 10, 2015, 8 pages.
[cited by applicant]
Final Office Action mailed on Sep. 19, 2019, for U.S. Appl. No. 16/260,100, filed Jan. 28, 2019, 18 pages.
[cited by applicant]
Final Office Action mailed on Jun. 24, 2020, for U.S. Appl. No. 15/901,231, filed Feb. 21, 2018, 16 pages.
[cited by applicant]
International Search Report mailed on Jan. 5, 2016, for PCT Application No. PCT/US2015/044513, filed on Aug. 10, 2015, 4 pages.
[cited by applicant]
International Search Report mailed on Jul. 2, 2018, for PCT Application No. PCT/US2018/025650, filed on Apr. 2, 2018, 2 pages.
[cited by applicant]
International Search Report mailed on Oct. 9, 2019, for PCT Application No. PCT/US2019/031215, filed on May 7, 2019, 9 pages.
[cited by applicant]
Non-Final Office Action mailed on May 30, 2019, for U.S. Appl. No. 15/502,642, filed Mar. 7, 2017, 23 pages.
[cited by applicant]
Non-Final Office Action mailed on May 31, 2019, for U.S. Appl. No. 16/260,100, filed Jan. 28, 2019, 24 pages.
[cited by applicant]
Non-Final Office Action mailed on Jul. 19, 2019, for U.S. Appl. No. 16/405,974, filed May 7, 2019, 9 pages.
[cited by applicant]
Non-Final Office Action mailed on Sep. 26, 2019, for U.S. Appl. No. 16/405,960, filed May 7, 2019, 23 pages.
[cited by applicant]
Non-Final Office Action mailed on Nov. 12, 2019, for U.S. Appl. No. 16/405,966, filed May 7, 2019, 7 pages.
[cited by applicant]
Non-Final Office Action mailed on Dec. 10, 2019, for U.S. Appl. No. 15/901,231, filed Feb. 21, 2018, 21 pages.
[cited by applicant]
Non-Final Office Action mailed on Dec. 11, 2019, for U.S. Appl. No. 16/405,987, filed May 7, 2019, 10 pages.
[cited by applicant]
Non-Final Office Action mailed on Dec. 12, 2019, for U.S. Appl. No. 16/405,994, filed May 7, 2019, 7 pages.
[cited by applicant]
Non-Final Office Action mailed on Mar. 25, 2020, for U.S. Appl. No. 16/405,966, filed May 7, 2019, 6 pages.
[cited by applicant]
Non-Final Office Action mailed on Apr. 9, 2020, for U.S. Appl. No. 16/405,960, filed May 7, 2019, 19 pages.
[cited by applicant]
Non-Final Office Action mailed on Jan. 21, 2021, for U.S. Appl. No. 15/901,231, filed Feb. 21, 2018, 17 pages.
[cited by applicant]
Notice of Allowance mailed on Sep. 3, 2019, for U.S. Appl. No. 16/405,974, filed May 7, 2019, 8 pages.
[cited by applicant]
Notice of Allowance mailed on Sep. 20, 2019, for U.S. Appl. No. 15/502,642, filed Mar. 7, 2017, 10 pages.
[cited by applicant]
Notice of Allowance mailed on Mar. 17, 2020, for U.S. Appl. No. 16/260,100, filed Jan. 28, 2019, 8 pages.
[cited by applicant]
Notice of Allowance mailed on Mar. 23, 2020, for U.S. Appl. No. 16/405,994, filed May 7, 2019, 8 pages.
[cited by applicant]
Notice of Allowance mailed on Jun. 5, 2020, for U.S. Appl. No. 16/405,987, filed May 7, 2019, 9 pages.
[cited by applicant]
Notice of Allowance mailed on Jul. 6, 2020, for U.S. Appl. No. 16/405,966, filed May 7, 2019, 6 pages.
[cited by applicant]
Notice of Allowance mailed on Aug. 12, 2020, for U.S. Appl. No. 16/405,960, filed May 7, 2019, 11 pages.
[cited by applicant]
Written Opinion of the International Searching Authority mailed on Jan. 5, 2016, for PCT Application No. PCT/US2015/044513, filed on Aug. 10, 2015, 13 pages.
[cited by applicant]
Written Opinion of the International Searching Authority mailed on Jul. 2, 2018, for PCT Application No. PCT/US2018/025650, filed on Apr. 2, 2018, 7 pages.
[cited by applicant]
Written Opinion of the International Searching Authority mailed on Oct. 9, 2019, for PCT Application No. PCT/US2019/031215, filed on May 7, 2019, 13 pages.
[cited by applicant]
Non-Final Office Action mailed on Oct. 21, 2021, for U.S. Appl. No. 16/938,096, filed Jul. 24, 2020, 13 pages.
[cited by applicant]
Non-Final Office Action mailed on Nov. 8, 2021, for U.S. Appl. No. 16/944,848, filed Jul. 31, 2020, 8 pages.
[cited by applicant]
Extended European Search Report mailed on Apr. 16, 2021, for EP Application No. 18 794 801.3, filed on Apr. 2, 2018, 17 pages.
[cited by applicant]
Final Office Action mailed on May 10, 2022, for U.S. Appl. No. 16/938,096, filed Jul. 24, 2020, 15 pages.
[cited by applicant]
Notice of Allowance mailed on May 13, 2022, for U.S. Appl. No. 16/944,848, filed Jul. 31, 2020, 9 pages.
[cited by applicant]
Office Action for EP App No. 19725538.3, dated Jul. 3, 2025, 5 pgs.
[cited by applicant]