Method of modulating sex hormone levels using a sex hormone secretion modulator
Provided are a hormone secretion modulator including a peptide derived from telomerase, more particularly, a peptide including an amino acid sequence of SEQ ID NO: 1, an amino acid sequence having a sequence identity of at least 80% with SEQ ID NO: 1, or a fragment thereof, a pharmaceutical composition including the hormone secretion modulator, and a use of the pharmaceutical composition for treatment, alleviation, or prevention of diseases caused by excessive or deficient levels hormones.
1. A method of increasing testosterone level in a male subject, or increasing follicle stimulating hormone (FSH), luteinizing hormone (LH), or gonadotropin-releasing hormone (GnRH) levels in a male or a female subject comprising administering to the subject an effective amount of the peptide of SEQ ID NO: 1.
2. The method of claim 1 , wherein the administration is once a day.
3. The method of claim 1 , wherein the administration is one to three times a day.
4. The method of claim 1 , further comprising administering to the subject an adjuvant.
5. The method of claim 4 , wherein the adjuvant is a granulocyte-macrophage colony-stimulating factor (GM-CSF).
6. The method of claim 5 , wherein GM-CSF is administered at a dosage of about 7 mg to about 700 mg.
7. The method of claim 5 , wherein GM-CSF is subcutaneously administered at about 1 minute to about 150 minutes before the administration of the peptide.
8. The method of claim 5 , wherein GM-CSF is subcutaneously administered at about 5 minutes to about 80 minutes before the administration of the peptide.
9. The method of claim 5 , wherein GM-CSF is subcutaneously administered at about 10 minutes to about 15 minutes before the administration of the peptide.
10. The method of claim 1 , wherein the subject is selected from a group consisting of humans, dogs, chickens, pigs, cows, sheep, guinea pigs, and monkeys.
11. The method of claim 1 , wherein the peptide of SEQ ID NO: 1 is administered through oral, rectal, transdermal, intravenous, intramuscular, intraperitoneal, intramedullary, epidural, or subcutaneous means.
12. The method of claim 1 , wherein the peptide of SEQ ID NO: 1 is administered through the oral means.
13. The method of claim 12 , wherein the peptide of SEQ ID NO: 1 is administered as tablets, pills, soft or hard capsules, granules, powders, solutions, or emulsions.
14. The method of claim 1 , wherein the peptide of SEQ ID NO: 1 is administered as injections, drips, lotions, ointments, gels, creams, suspensions, emulsions, suppositories, patches, or sprays.
15. The method of claim 1 , wherein the peptide of SEQ ID NO: 1 is administered at a dosage of about 0.1 μg/kg/day to about 1 g/kg/day.
16. The method of claim 1 , wherein the peptide of SEQ ID NO: 1 is administered at a dosage of about 1 μg/kg/day to about 10 mg/kg/day.
17. The method of claim 1 , wherein the peptide of SEQ ID NO: 1 is administered at a dosage of about 10 μg/kg/day to about 1 mg/kg/day.
18. The method of claim 1 , wherein the peptide of SEQ ID NO: 1 is administered at a dosage of about 50 μg/kg/day to about 100 μg/kg/day.
19. A method of increasing testosterone level in a male subject comprising administering to the subject an effective amount of the peptide of SEQ ID NO: 1.
20. A method of increasing follicle stimulating hormone (FSH), luteinizing hormone (LH), or gonadotropin-releasing hormone (GnRH) levels in a male or a female subject comprising administering to the subject an effective amount of the peptide of SEQ ID NO: 1.