Protective solution for preventing or reducing reperfusion injury of the brain and the whole body
The present invention relates to a protective solution for preventing or reducing reperfusion injury of the brain which contains magnesium ions and which has an osmolality of 350 to 600 mOsm/L, a pH value of 6.8 to 7.8 and albumin in an amount of 1 to 20% by weight.
1. A protective solution for reducing reperfusion injury of the brain comprising magnesium ions and albumin in an amount of 1 to 20% by weight, wherein said protective solution has an osmolality of 440 to 550 mOsm/L and a pH value of 7.5 to 7.8.
2. The protective solution according to claim 1 , characterized in that the albumin is human serum albumin.
3. The protective solution according to claim 2 , characterized in that it contains lidocaine in an amount of 0.05-1.0 g per l of solution.
4. The protective solution according to claim 3 , characterized in that it contains a sugar alcohol in an amount of 1.0-50 g/l.
5. The protective solution according to claim 2 characterized in that it contains a sugar alcohol in an amount of 1.0-50 g/l.
6. The protective solution according to claim 5 , characterized in that it contains mannitol in an amount of 1.0-50 g/l.
7. The protective solution according to claim 2 , characterized in that it contains citrate ions in a concentration of 20 to 100 mmol/l solution.
8. The protective solution according to claim 1 , characterized in that it contains lidocaine in an amount of 0.05-1.0 g per l of solution.
9. The protective solution according to claim 8 , characterized in that it contains 10,000 to 50,000 IU heparin per liter of solution.
10. The protective solution according to claim 8 , characterized in that it contains citrate ions in a concentration of 20 to 100 mmol/l solution.
11. The protective solution according to claim 1 , characterized in that it contains a sugar alcohol in an amount of 1.0-50 g/l.
12. The protective solution according to claim 11 , characterized in that the sugar alcohol is mannitol.
13. The protective solution according to claim 12 , characterized in that it contains 10,000 to 50,000 IU heparin per liter of solution.
14. The protective solution according to claim 12 , characterized in that it contains citrate ions in a concentration of 20 to 100 mmol/l solution.
15. The protective solution according to claim 11 , characterized in that it contains citrate ions in a concentration of 20 to 100 mmol/l solution.
16. The protective solution according to claim 1 , characterized in that the magnesium is present in a concentration of 0.1 to 15 mmol/l.
17. The protective solution according to claim 16 , characterized in that it contains citrate ions in a concentration of 20 to 100 mmol/l solution.
18. The protective solution according to claim 1 , characterized in that it contains 10,000 to 50,000 IU heparin per liter of solution.
19. The protective solution according to claim 18 , characterized in that it contains citrate ions in a concentration of 20 to 100 mmol/l solution.
20. The protective solution according to claim 1 , characterized in that it contains citrate ions in a concentration of 20 to 100 mmol/l solution.
21. The protective solution according to claim 1 , characterized in that it contains Cyclosporin in an amount of 50 mg to 1300 mg per liter of protective solution.
22. The protective solution according to claim 21 , characterized in that it contains citrate ions in a concentration of 20 to 100 mmol/l solution.
23. The protective solution according to claim 1 , wherein the solution comprises less than 0.5 mmol/l calcium ions.
24. The protective solution according to claim 1 , wherein the solution comprises magnesium which is present in a concentration of 1.0 to 15 mmol/l, lidocaine in an amount of 0.05-1.0 g per l of solution, a sugar alcohol in an amount of 1.0-50 g/l, 5000 to 50,000 IU heparin/l solution, and citrate ions in an amount of 20 to 100 mmol/l solution.
25. The protective solution according to claim 1 , wherein said protective solution has an osmolality of 440 to 500 mOsm/L.
26. A method for reducing reperfusion injury of the brain after cardiopulmonary resuscitation comprising administering a protective solution comprising magnesium ions and albumin in an amount of 1 to 20% by weight, wherein said protective solution has an osmolality of 440 to 550 mOsm/L and a pH value of 7.5 to 7.8.
27. The method of claim 26 , wherein said protective solution further contains 0.1-25.0 mmol potassium per liter of solution.