Methods and apparatuses for skin treatment using non-thermal tissue ablation
Disclosed herein are methods, apparatuses, and devices for treating skin, such as skin tightening or for treating diseases, disorders, and conditions that would benefit from tissue area or volume reduction, skin restoration, skin tightening, skin lifting, or skin repositioning. Such methods and devices include an ablative apparatus, a removal apparatus, and/or a positioning apparatus.
1. A device comprising an ablative apparatus for non-thermal tissue ablation, said apparatus comprising:
a skin-penetrating component configured to provide an ablated tissue portion having a volume of less than 6 mm 3 and a change in width as a function of depth, wherein said change in width is of between about 100 μm to about 500 μm as a function of depth,
wherein said skin-penetrating component is configured to provide the ablated tissue portion without transfer of thermal energy to tissue surrounding the ablated tissue portion; and
wherein said skin-penetrating component comprises a drill configured to rotate at a speed of between 50 rpm and 2500 rpm; and
a positioning apparatus for positioning skin, the positioning apparatus comprising a substrate and a cryosource, wherein the substrate is configurably attached to the cryosource and provides a cryotemperature to the skin of about 0 degrees C. or lower.
2. The device of claim 1 , wherein
said skin-penetrating component is configured to provide an ablated tissue portion having a width to depth ratio of between about 1:0.3 to about 1:1 or of between about 1:25 to about 1:75.
3. The device of claim 1 , wherein said apparatus further comprises one or more components that produce a mechanical force.
4. The device of claim 3 , wherein said one or more components are selected from the group consisting of a motor, an axle, an adjustable depth stop, an in-flow tube, a return electrode, a generator, and an electrical insulator.
5. The device of claim 1 , wherein said apparatus comprises a plurality of said skin-penetrating components in an array.
6. The device of claim 1 , wherein said apparatus is configured to provide from about 10 to about 10000 ablated tissue portions per cm 2 area of the skin region.
7. The device of claim 1 , wherein said ablative apparatus removes about 5% of skin within a treatment area.
8. The device of claim 1 , further comprising a removal apparatus for removing one or more ablated tissue portion(s).
9. The device of claim 8 , wherein the removal apparatus comprises a (i) substrate comprising a plurality of holes; and (ii) a vacuum source, wherein said substrate is configurably attached to said vacuum source to deliver vacuum through each hole and to each of said one or more ablated tissue portion(s).
10. The device of claim 8 , wherein the removal apparatus comprises an adhesive layer or an array of probes configured to contact each of said one or more ablated tissue portion(s).
11. The device of claim 8 , wherein the removal apparatus comprises
(i) a wire having a first attachment point and a second attachment point;
(ii) an axle having a sharpened distal end, a center portion, and a proximal end, wherein said first attachment point of said wire is configurably attached to said distal end of said axle and said second attachment point of said wire is configurably attached to said center portion of said axle, and wherein said axle is configured to contact each of said one or more ablated tissue portion(s);
(iii) a motor configured to rotate said wire, wherein said motor is configurably attached to said proximal end of said axle;
(iv) a vacuum source, and
(v) a substrate comprising a plurality of holes, wherein said substrate is configurably attached to the vacuum source to deliver vacuum through each hole and to each of said one or more ablated tissue portion(s).
12. The device of claim 1 , wherein the positioning apparatus comprises at least two sufficiently parallel tensioning rods configured to compress or stretch skin, wherein said rods are separated by a distance of more than about 0.5 mm and exert a compressing or stretching force, respectively.
13. The device of claim 1 , wherein the positioning apparatus comprises a plurality of needles configured to grip skin, wherein said needles exert a gripping force.
14. The device of claim 1 , wherein the positioning apparatus comprises a plurality of microhooks or microbarbs, wherein each microhook or microbarb is separated by a distance of more than about 0.5 mm and exerts a stretching force.
15. The device of claim 1 , wherein the positioning apparatus comprises a vacuum tube having at least one dimension of greater than 1 mm and a vacuum source, wherein said vacuum tube is configurably attached to said source and exerts a stretching force.
16. The device of claim 1 , wherein the positioning apparatus comprises a substrate having at least one dimension of about 1 mm and a cryosource, wherein said substrate is configurably attached to said cryosource and provides a cryotemperature of about 0° C. or lower.
17. The device of claim 1 , wherein the positioning apparatus comprises an adhesive layer having at least one dimension of about 1 mm, wherein said positioning apparatus is configured to position skin prior to ablation with said ablative apparatus and/or prior to removal with said removal apparatus.
18. The device of claim 1 , wherein the positioning apparatus comprises one or more sensors to detect position, temperature, skin proximity, skin contact, and/or changes in inductive coupling.
19. A method of treating skin, comprising:
(i) positioning said skin using a compressive or a stretching force applied across said skin and providing a cryotemperature to the skin of about 0 degrees C. or lower;
(ii) contacting the skin with a skin-penetrating component comprising a drill rotating at a speed of between 50 rpm and 2500 rpm;
(iii) forming a plurality of ablated tissue portions having a volume of less than 6 mm 3 and a change in width as a function of depth without transfer of thermal energy to tissue surrounding the ablated tissue portion, wherein said change in width is of between about 100 μm to about 500 μm as a function of depth; and
(iv) removing said plurality of ablated tissue portions, thereby treating said skin.
20. The method of claim 19 , forming a plurality of ablated tissue portions having a width to depth ratio of between about 1:0.3 to about 1:1 or of between about 1:25 to about 1:75.
21. The method of claim 19 , comprising removing said plurality of ablated tissue portions, wherein 5% of said skin within a treatment area is removed.
22. The method of claim 19 , wherein said compressive force applied across said skin compresses said skin in a direction orthogonal to Langer lines.
23. The method of claim 19 , further comprising positioning said skin using a compressive force applied across said skin prior to forming a plurality of ablated tissue portions and removing said plurality of ablated tissue portions.