Calcium formate as a supplement to prevent neural tube defects
Compositions and method for treating a folate-resistant disease in a subject are disclosed. The methods involve administering to the subject an effective amount of a composition containing a formate. For example, the method can be used to reducing the risk of neural tube defects during pregnancy. The method can also be used to treat other conditions normally treatable by folate supplementation.
1. A method for reducing the risk of neural tube defects during pregnancy in a subject, comprising administering to a pregnant subject an effective amount of a composition comprising a formate.
2. The method of claim 1 , wherein the formate comprises a salt or ester of formic acid.
3. The method of claim 2 , wherein the formate comprises calcium formate, sodium formate, ammonium formate, potassium formate, magnesium formate, or a combination thereof.
4. The method of claim 3 , wherein the formate comprises calcium formate.
5. The method of claim 1 , wherein the composition further comprises vitamin B12.
6. The method of claim 1 , wherein the composition further comprises iron.
7. The method of claim 1 , wherein the composition further comprises choline.
8. The method of claim 1 , wherein the composition comprises about 0.5 mg to about 10,000 mg of the formate.