Treating cancer with a combination of a PD-1 antagonist and dinaciclib
View Patent ↗The present disclosure describes combination therapies comprising an antagonist of Programmed Death 1 receptor (PD-1) and the CDK inhibitor dincaciclib, and the use of the combination therapies for the treatment of cancer, and in particular for treating cancers that express PD-L1.
1. A method for treating a cancer in an individual comprising administering to the individual a combination therapy which comprises an isolated monoclonal antibody that binds to Programmed Death 1 protein (PD-1), wherein the isolated anti-PD-1 monoclonal antibody is MK-3475, and a dinaciclib compound, wherein the dinaciclib compound is the compound of Formula I
or a pharmaceutically acceptable salt of the compound of Formula I.
2. The method of claim 1 , wherein the cancer is a solid tumor.
3. The method of claim 1 , wherein the cancer is a Heme malignancy.
4. The method of claim 1 , wherein the individual has a cancer that tests positive for PD-L1 expression by an immunohistochemical (IHC) assay.
5. The method of claim 1 , wherein the cancer is bladder cancer, breast cancer, clear cell kidney cancer, head/neck squamous cell carcinoma, lung squamous cell carcinoma, malignant melanoma, non-small-cell lung cancer (NSCLC), ovarian cancer, pancreatic cancer, prostate cancer, renal cell cancer, small-cell lung cancer (SCLC), triple negative breast cancer, acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL), chronic myeloid leukemia (CML), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, Hodgkin's lymphoma (HL), mantle cell lymphoma (MCL), multiple myeloma (MM), myeloid cell leukemia-1 protein (Mcl-1), myelodysplastic syndrome (MDS), non-Hodgkin's lymphoma (NHL), or small lymphocytic lymphoma (SLL).