Ester nitrates derivatives of aromatic aldehydes with multiple pharmalogic properties to treat sickle cell disease

Inventors: Martin Safo (Richmond, VA); Jurgen Venitz (Richmond, VA); Richmond Danso-Danquah (Henrico, VA); Tanvi Deshpande (Baltimore, MD); Yan Zhang (Glen Allen, VA)

Assignee: Virginia Commonwealth University

C07D307/58 C07D213/30

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Quick Facts

Patent No.: US 10,800,751
App. No.: 14/913,180
Granted: Oct 13, 2020
Kind: B2

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Abstract

The invention provides new aromatic aldehyde compounds that have greater potency in increasing the affinity of Hb for oxygen, greater potency for preventing sickling, and additional pharmacologic properties that ameliorate other symptoms of SCD. The invention further provides methods for treating SCD by providing a subject having SCD with a compound according to the invention.

Claims (6)

1. A compound of the formula:

wherein R1 is H and R4 is alkoxy; and M is O; Q is (CH 2 )q; R2 is H; R3 is OH; and X is N; Y and Z are C; and n is 1; and p is 0; and q is 1; and salts thereof.

2. The compound according to claim 1 , having the following structure:

3. The compound according to claim 1 , having the following structure:

4. The compound according to claim 1 , having the following structure:

5. The compound according to claim 1 , having the following structure:

Assignments (1)

CONFIRMATORY LICENSE Recorded Nov 21, 2022

From: VIRGINIA COMMENWEALTH UNIVERSITY

To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT

Reel/Frame 061974/0778 →

Continuity (2)

Provisional Application 61869162 · Aug 23, 2013

Related Publication 20160221978A1 · Aug 4, 2016