2,2-difluorodioxolo A

1. A compound of formula I:

wherein:

R 1a and R 1b are independently selected from the group consisting of:

(a) hydrogen,

(b) C 1-6 alkyl, unsubstituted or substituted with one or more halogen, and

(c) C 3-6 cycloalkyl;

X is

 wherein:

Y is CH or N, wherein:

(a) when Y is CH, R 2 and R 3 are independently selected from the group consisting of:

(i) C 1-6 alkyl, which is substituted with one or more halogen, hydroxy, phenyl (optionally substituted with C 1-6 alkyl, halogen or CF 3 ), C 3-6 cycloalkyl, or a mono- or bicyclic heterocyclic moiety comprising up to 8 carbon atoms and one or more heteroatoms selected from N, S, or O (optionally substituted with C 1-6 alkyl),

(ii) —C 3-6 cycloalkyl, unsubstituted or substituted with one or more halogen or C 1-6 alkyl (optionally substituted with one or more halogen),

(iii) —(C═O)O—C 1-6 alkyl, and

(iv) a mono- or bicyclic heterocyclic moiety comprising up to 8 carbon atoms and one or more heteroatoms selected from N, S, or O (optionally substituted with C 1-6 alkyl),

when Y is N, R 2 and R 3 are independently selected from the group consisting of:

(i) hydrogen,

(ii) C 1-6 alkyl, which is unsubstituted or substituted with one or more halogen, hydroxy, phenyl (optionally substituted with C 1-6 alkyl, halogen or CF 3 ), C 3-6 cycloalkyl, or a mono- or bicyclic heterocyclic moiety comprising up to 8 carbon atoms and one or more heteroatoms selected from N, S, or O (optionally substituted with C 1-6 alkyl),

(iii) —C 3-6 cycloalkyl, unsubstituted or substituted with one or more halogen or C 1-6 alkyl (optionally substituted with one or more halogen),

(iv) —(C═O)O—C 1-6 alkyl, and

(v) a mono- or bicyclic heterocyclic moiety comprising up to 8 carbon atoms and one or more heteroatoms selected from N, S, or O (optionally substituted with C 1-6 alkyl);

or R 2 and R 3 are joined to form a cyclic moiety selected from:

(a) C 3-6 cycloalkyl, unsubstituted or substituted with one or more substituents selected from R 4 , or

(b) a mono- or bicyclic heterocyclic moiety comprising up to 10 carbon atoms and one or more heteroatoms selected from N, S, or O, unsubstituted or substituted on either a carbon or a heteroatom with one or more substituents selected from R 4 ;

R 4 is selected from the group consisting of:

(a) hydroxyl,

(b) halogen,

(c) C 1-6 alkyl, optionally substituted with one or more halogen or C 3-6 cycloalkyl,

(d) —C 3-6 cycloalkyl,

(e) —O—C 1-6 alkyl,

(f) —(O) m —(CH 2 ) p O—C 1-3 alkyl,

(g) oxo,

(h) —O m -phenyl, where the phenyl is optionally substituted with halogen, C 1-6 alkyl or —O—C 1-6 alkyl (wherein the C 1-6 alkyl or —O—C 1-6 alkyl are substituted with —O—C 1-6 alkyl), and

(i) heterocycle, which is optionally substituted with one or more halogen, C 1-6 alkyl, or phenyl (optionally substituted with halogen or CF 3 );

wherein if two R 4 substituents are attached to the same carbon atom, they may optionally be joined to form a spirocyclic moiety;

m is 0 or 1 (wherein if m is 0, a bond is present);

n is 1, 2 or 3; and,

p is 1, 2 or 3;

or a pharmaceutically acceptable salt thereof.

2. A compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1a and R 1b are independently selected from hydrogen, methyl, cyclopropyl, or —CHF 2 .

3. A compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein X is

Y is N.

4. A compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein X is

Y is CH.

5. A compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein X is

Y is N, and R 2 and R 3 are independently selected from the group consisting of:

(a) hydrogen,

(b) methyl, which is optionally substituted with one or more halogen, hydroxy, cyclopropyl, phenyl (optionally substituted with C 1-6 alkyl, halogen or —CF 3 ), or a 5- or 6-membered heteroaryl (optionally substituted with C 1-6 alkyl),

(c) —(C═O)O—CH 3 ,

(d) C 3-6 cycloalkyl, which is optionally substituted with —CF 3 ,

(e) saturated or partially unsaturated mono- or bicyclic heterocycle comprising up to 8 carbon atoms and from one to three nitrogen atoms, and

(f) a 5- or 6-membered heteroaryl (optionally substituted with C 1-6 alkyl).

6. A compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein X is

Y is CH or N, and R 2 and R 3 are joined to form a monocyclic or bicyclic moiety comprising up to 10 carbon atoms and from one to four heteroatom selected from N, S or O, which is unsubstituted or substituted on either a carbon or a heteroatom with one or more substituents selected from R 4 .

7. A compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein X is

Y is CH or N, and R 2 and R 3 are joined to form a heterocyclic moiety selected from the group consisting of:

wherein the heterocyclic moiety is unsubstituted or substituted on either a carbon or a heteroatom with one or more substituents selected from R 4 .

8. A compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein X is

Y is CH or N, and R 2 and R 3 are joined to form a heterocyclic moiety selected from the group consisting of:

wherein the heterocyclic moiety is unsubstituted or substituted on either a carbon or a heteroatom with one or more substituents selected from R 4 .

9. A compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein X is

Y is CH or N, and R 2 and R 3 are joined to form a heterocyclic moiety selected from the group consisting of:

wherein the heterocyclic moiety is unsubstituted or substituted on either a carbon or a heteroatom with one or more substituents selected from R 4 .

10. A compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein X is

Y is CH or N, and R 2 and R 3 are joined to form a heterocyclic moiety selected from the group consisting of:

wherein the heterocyclic moiety is unsubstituted or substituted on either a carbon or a heteroatom with one or more substituents selected from R 4 .

11. A compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein X is

Y is N, and R 2 and R 3 are joined to form a heterocyclic moiety selected from

which can be unsubstituted or substituted with one or more substituents selected from R 4 .

12. A compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 4 is selected from the group consisting of:

(a) hydroxy,

(b) fluoro,

(c) chloro,

(d) C 1-6 alkyl, optionally substituted with one or more fluoro, chloro or cyclopropyl,

(e) C 3-6 cycloalkyl,

(f) —O—CH 3 ,

(g) —(CH 2 ) 2 OCH 3 ,

(h) —O(CH 2 ) 2 OCH 3 ,

(i) oxo,

(j) —O-phenyl, which is optionally substituted with fluoro;

(k) phenyl, which is optionally substituted with fluoro, C 1-6 alkyl or —O—C 1-6 alkyl (wherein the C 1-6 alkyl or —O—C 1-6 alkyl are substituted with —O—C 1-6 alkyl)C 1-6 alkyl, and

(l) heterocycle selected from pyridinyl, pyrimidinyl, thiazoyl, thiadiazolyl or piperidinyl, which is optionally substituted with one or more fluoro, chloro or phenyl (optionally substituted with halogen or CF 3 ).

13. A compound selected from the group consisting of:

8-((2-chloropyridin-3-yl)methyl)-2,2-difluoro-[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

(S)-2,2-difluoro-8-((2-(3-(4-fluorophenyl)pyrrolidin-1-yl)pyridin-3-yl)methyl)-[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

(S)-2,2-difluoro-8-((2-(3-(4-(trifluoromethyl)phenyl)pyrrolidin-1-yl)pyridin-3-yl)methyl)-[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

(8-(2-(5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)ethyl)-2,2-difluoro-[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-{2-[5-(trifluoromethyl)-1,3-dihydro-2H-isoindol-2-yl]ethyl}[1,3]dioxolo[4,5-h][1,2,4]triazolo [1,5-c]quinazolin-5-amine;

2,2-difluoro-8-[2-(5-fluoro-1,3-dihydro-2H-isoindol-2-yl)ethyl][1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-{2-[2-(trifluoromethyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]ethyl}[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[2-(3-ethyl-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)ethyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[2-(1,3-dihydro-2H-pyrrolo[3,4-c]pyridin-2-yl)ethyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-[2-(2-methyl-6,7-dihydro[1,3]oxazolo[5,4-c]pyridin-5(4H)-yl)ethyl][1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-[2-(2-methyl-6,7-dihydro[1,3]thiazolo[4,5-c]pyridin-5(4H)-yl)ethyl][1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[2-(2-cyclopropyl-6,7-dihydro[1,3]oxazolo[5,4-c]pyridin-5(4H)-yl)ethyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-[2-(3-fluoroazetidin-1-yl)ethyl][1,3]dioxolo[4,5-h][1,2,4] triazolo[1,5-c]quinazolin-5-amine;

8-[2-(3-ethyl-3-fluoroazetidin-1-yl)ethyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[2-(3-cyclopropyl-3-fluoroazetidin-1-yl)ethyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[2-(3,3-difluoroazetidin-1-yl)ethyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

1-[2-(5-amino-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-8-yl)ethyl]-3-(trifluoromethyl) azetidin-3-ol;

2,2-difluoro-8-{2-[3-fluoro-3-(trifluoromethyl)azetidin-1-yl]ethyl}[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-{2-[(2R,4S)-4-fluoro-2-methylpyrrolidin-1-yl]ethyl}[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-{2-[(3S,4S)-3,4-difluoropyrrolidin-1-yl]ethyl}-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[2-(3,3-difluoropyrrolidin-1-yl)ethyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-{2-[(2R)-4,4-difluoro-2-methylpyrrolidin-1-yl]ethyl}-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-{2-[(2S)-4,4-difluoro-2-methylpyrrolidin-1-yl]ethyl}-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-[2-(4-fluoropiperidin-1-yl)ethyl][1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-[2-(4-fluoro-4-methylpiperidin-1-yl)ethyl][1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[2-(3,3-difluoropiperidin-1-yl)ethyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo [1,5-c]quinazolin-5-amine;

8-[2-(4,4-difluoropiperidin-1-yl)ethyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo [1,5-c]quinazolin-5-amine;

8-{2-[(2R)-4,4-difluoro-2-methylpiperidin-1-yl]ethyl}-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[2-(9,9-difluoro-3-oxa-7-azabicyclo[3.3.1]non-7-yl)ethyl]-2,2-difluoro[1,3]dioxolo [4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[2-(3,3-dimethylazetidin-1-yl)ethyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-{2-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]ethyl}-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[2-(3-azabicyclo[3.1.0]hex-3-yl)ethyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-{2-[(3S)-3-phenylpyrrolidin-1-yl]ethyl}[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-{2-[(3R)-3-phenylpyrrolidin-1-yl]ethyl}[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-[2-(4-methylpiperidin-1-yl)ethyl][1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[2-(3,3-dimethylpiperidin-1-yl)ethyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-{2-[(3R)-3-methoxypiperidin-1-yl]ethyl}[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-[2-(4-methyl-3,6-dihydropyridin-1(2H)-yl)ethyl][1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-{2-[(2R)-2-methylmorpholin-4-yl]ethyl}[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-{2-[(3S)-3-methylmorpholin-4-yl]ethyl}[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-{2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]ethyl}-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-{2-[(2R)-2-methyl-4-(2-methyl-1,3-thiazol-5-yl)piperazin-1-yl]ethyl}[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-{2-[(2R)-4-(4-chloro-1,2,5-thiadiazol-3-yl)-2-methylpiperazin-1-yl]ethyl}-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

4-[2-(5-amino-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-8-yl)ethyl]-1-methylpiperazin-2-one;

4-[2-(5-amino-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-8-yl)ethyl]-1-(cyclopropylmethyl)piperazin-2-one;

4-[2-(5-amino-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-8-yl)ethyl]-1-cyclopentylpiperazin-2-one;

4-[2-(5-amino-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo [1,5-c]quinazolin-8-yl)ethyl]-1-(3-fluorophenyl)piperazin-2-one;

2,2-difluoro-8-{2-[(4aR,7aR)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]ethyl}[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-{2-[(3aS)-hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]ethyl}[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[2-(2,8-diazaspiro[4.5]dec-2-yl)ethyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[2-(3,9-diazaspiro[5.5]undec-3-yl)ethyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[2-(1,8-diazaspiro[4.5]dec-1-yl)ethyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[2-(2,9-diazaspiro[5.5]undec-2-yl)ethyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo [1,5-c]quinazolin-5-amine;

8-[2-(2-azaspiro[3.3]hept-6-ylamino)ethyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-(2-{[1-(trifluoromethyl)cyclobutyl]amino}ethyl)[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-(2-{[4-(trifluoromethyl)benzyl]amino}ethyl)[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-(2-{(cyclopropylmethyl)[(4-methyl-1,3-thiazol-2-yl)methyl]amino}ethyl)-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-(2-{(cyclopropylmethyl)[(2-methyl-1,3-thiazol-5-yl)methyl]amino}ethyl)-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-{2-[3-(trifluoromethyl)piperidin-1-yl]ethyl}[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-{2-[(2R,6R)-2,6-dimethylmorpholin-4-yl]ethyl}-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-[2-(3-fluoro-3-methylpiperidin-1-yl)ethyl][1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[2-(6,6-difluoro-2-azabicyclo[2.2.1]hept-2-yl)ethyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[2-(3,3-difluoro-2-methylpiperidin-1-yl)ethyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

1-(2-(5-amino-2,2-difluoro-[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-8-yl)ethyl)-3-(trifluoromethyl)piperidin-3-ol;

2,2-difluoro-8-(2-(3-fluoro-3-(trifluoromethyl)piperidin-1-yl)ethyl)-[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

(R)-8-(2-(1H-pyrrolo[3,4-c]pyridin-2(3H)-yl)propyl)-2,2-difluoro-[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[(2R)-2-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-1-yl)propyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[(2R)-2-(2,3-dihydro-1H-pyrrolo[2,3-c]pyridin-1-yl)propyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[(2R)-2-(3,4-dihydro-2,7-naphthyridin-2(1H)-yl)propyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[(2R)-2-(5,8-dihydro-1,7-naphthyridin-7(6H)-yl)propyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-[(2R)-2-(2-methyl-6,7-dihydro[1,3]oxazolo[5,4-c]pyridine-5(4H)-yl)propyl][1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-[(2R)-2-(2-methyl-6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-5(4H)-yl)propyl][1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[(2R)-2-(2-cyclopropyl-6,7-dihydro[1,3]oxazolo[5,4-c]pyridin-5(4H)-yl)propyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-[(2R)-2-(2-methyl-6,7-dihydro[1,3]thiazolo[4,5-c]pyridin-5(4H)-yl)propyl][1,31dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-[(2R)-2-(2-methyl-6,7-dihydropyrazolo[1,5-a]pyrazin-5(4H)-yl)propyl][1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-[(2R)-2-(3-fluoro-3-methylazetidin-1-yl)propyl][1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-{(2R)-2-[3-fluoro-3-methylpiperidin-1-yl]propyl}[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

(S)-8-(2-(1H-pyrrolo[3,4-c]pyridin-2(3H)-yl)propyl)-2,2-difluoro-[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-[(2S)-2-(3-fluoro-3-methylazetidin-1-yl)propyl][1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-{(2S)-2-[3-fluoro-3-methylpiperidin-1-yl]propyl}[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[2-(5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)propyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[2-(3,3-difluoroazetidin-1-yl)propyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[2-(3,3-difluoropiperidin-1-yl)propyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-(3,3-difluoro-2-(5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)propyl)-2,2-difluoro-[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-(2-(1H-pyrazol-1-yl)ethyl)-2,2-difluoro-[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

6-(2-(5-amino-2,2-difluoro-[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-8-yl)ethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;

2,2-difluoro-8-(2-(3-fluoroazetidin-1-yl)-2-methylpropyl)-[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-((7-(4-fluorophenyl)-4,7-diazaspiro[2.5]octan-4-yl)methyl)-[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-{[7-(5-fluoropyridin-2-yl)-4,7-diazaspiro[2.5]oct-4-yl]methyl}[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-{[7-(3-fluorophenyl)-4,7-diazaspiro[2.5]oct-4-yl]methyl}[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-({7-[4-(2-methoxyethoxy)phenyl]-4,7-diazaspiro[2.5]oct-4-yl}methyl)[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-{[(2R)-4-(4-fluorophenyl)-2-methylpiperazin-1-yl]methyl}[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-{[(2R)-2-methyl-4-(2-methyl-1,3-thiazol-5-yl)piperazin-1-yl]methyl}[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-{[(2R)-4-(4-chloro-1,2,5-thiadiazol-3-yl)-2-methylpiperazin-1-yl]methyl}-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-((3,3-difluoroazetidin-1-yl)methyl)-2,2-difluoro-[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[(3,3-dimethylazetidin-1-yl)methyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-[(3-fluoro-3-methylazetidin-1-yl)methyl][1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[(3-ethyl-3-fluoroazetidin-1-yl)methyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

11-[(5-amino-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-8-yl)methyl]-3-(trifluoromethyl) azetidin-3-ol;

2,2-difluoro-8-{[3-fluoro-3-(trifluoromethyl)azetidin-1-yl]methyl}[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-{[(3S,4S)-3,4-difluoropyrrolidin-1-yl]methyl}-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[(3,3-difluoropyrrolidin-1-yl)methyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-{[4-(4-fluorophenoxy) piperidin-1-yl]methyl}[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[(3,3-difluoropiperidin-1-yl)methyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[(4,4-difluoropiperidin-1-yl)methyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-[(5-fluoro-1,3-dihydro-2H-isoindol-2-yl)methyl][1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-{[2-(trifluoromethyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]methyl}[1,3]dioxolo [4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[(3-ethyl-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-{[5-(trifluoromethyl)-1,3-dihydro-2H-isoindol-2-yl]methyl}[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-({[4-(trifluoromethyl)benzyl]amino}methyl)[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-({[1-(trifluoromethyl)cyclobutyl]amino}methyl)[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[(dimethylamino)methyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-({(cyclopropylmethyl)[(4-methyl-1,3-thiazol-2-yl)methyl]amino}methyl)-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-((1H-pyrazol-1-yl)methyl)-2,2-difluoro-[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-{[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2,2-difluoro [1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[1-(3,3-difluoroazetidin-1-yl)ethyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-{1-[(3S,4S)-3,4-difluoropyrrolidin-1-yl]ethyl}-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[1-(3,3-difluoropiperidin-1-yl)ethyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-(3-(5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)propyl)-2,2-difluoro-[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

(R)-2,2-difluoro-8-(1-(2,2,2-trifluoroethyl)piperidin-3-yl)-[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

(R)-8-(1-(2,2-difluoroethyl)piperidin-3-yl)-2,2-difluoro-[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-(1-(3,3,3-trifluoropropyl)piperidin-3-yl)-[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-[1-(3-fluorophenyl)piperidin-3-yl][1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[1-(3,5-difluorophenyl) piperidin-3-yl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-(1-pyrimidin-5-ylpiperidin-3-yl)[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

dimethyl[(5-amino-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-8-yl)methyl]propanedioate;

2-[(5-amino-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-8-yl)methyl]propane-1,3-diol;

8-[3-chloro-2-(chloromethyl)propyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[(1-cyclobutylazetidin-3-yl)methyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-{[1-(2,2-difluoropropyl)azetidin-3-yl]methyl}-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-[(1-pyridin-2-ylazetidin-3-yl)methyl][1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-{[1-(3,3,3-trifluoropropyl)pyrrolidin-3-yl]methyl}[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-{[1-(2,2-difluoroethyl)pyrrolidin-3-yl]methyl}-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

2,2-difluoro-8-{[1-(2-methoxyethyl)pyrrolidin-3-yl]methyl}[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[(2S)-2-amino-2-cyclopropylethyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[(2R)-2-amino-2-cyclopropylethyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

8-[(1S,3S)-3-(3,3-difluoropiperidin-1-yl)cyclopentyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine; or,

8-[(1S,3R)-3-(3,3-difluoropiperidin-1-yl)cyclopentyl]-2,2-difluoro[1,3]dioxolo[4,5-h][1,2,4]triazolo[1,5-c]quinazolin-5-amine;

or a pharmaceutically acceptable salt thereof.

14. A pharmaceutical composition that comprises an inert carrier and a compound of claim 1 or a pharmaceutically acceptable salt thereof.