Methods of reducing mammographic breast density and/or breast cancer risk
The present disclosure is directed to generally methods for treating mammographic breast density and/or breast stiffness in a patient in need thereof, such as a premenopausal or perimenopausal patient, comprising the administration of an effective amount of androgenic agent and an effective amount of an aromatase inhibitor. These methods may also be useful in post-menopausal woman.
1. A method of treating mammographic breast density and/or breast stiffness in a patient in need thereof, comprising administering to the patient a subcutaneous implant comprising:
i) an effective amount of testosterone; and
ii) 0.1-4 mg of anastrozole.
2. The method of claim 1 , wherein the patient is peri-menopausal.
3. The method of claim 1 , wherein the patient's breast has a mammographic breast density of 25% or greater.
4. The method of claim 1 , wherein the method enhances, increases, or improves, mammographic visualization or detection of the breast.
5. The method of claim 1 , wherein the method enhances, increases, or improves, breast compression during mammographic visualization or detection of the breast.
6. The method of claim 1 , wherein the method enhances, increases, or improves, the treated patient's compliance of having regular mammographic visualizations or detections.
7. The method of claim 1 , wherein the subcutaneous implant comprises:
i) 50-150 mg of the testosterone; and
ii) 1 mg, 2 mg, or 3 mg of the anastrozole.
8. The method of claim 7 , wherein the patient is premenopausal.
9. The method of claim 7 , wherein the patient is peri-menopausal.
10. The method of claim 7 , wherein the patient is post-menopausal.
11. The method of claim 7 , wherein the patient's breast has a BIRADS score of 3 or 4 (or c or d).
12. The method of claim 7 , wherein the patient's breast has a mammographic breast density of 7.5% or greater.
13. The method of claim 7 , wherein the method reduces or decreases the mammographic breast density of the patient's breast between one or more annual intervening mammographic detections.
14. The method of claim 7 , wherein the method reduces or decreases the breast stiffness of the patient's breast between one or more annual intervening mammographic detections.