Use of buprenorphine dimer in the treatment of peripheral neuropathic pain
The present invention provides method and compositions for the treatment of peripheral neuropathic pain by administering to a patient a therapeutically effective amount of a buprenorphine dimer compound, wherein the two buprenorphine portions are linked via an ethylene spacer, and wherein the spacer is bonded to the two opioid molecules via an ether bond. Preferably, the active agent is provided in the form of an injectable depot.
1. A method of treating a patient suffering from peripheral neuropathic pain which comprises parenterally administering to said patient a therapeutically effective dose of a pharmaceutical composition comprising a pharmaceutically acceptable carrier or excipient and buprenorphine dimer compound having Formula (I):
or a pharmaceutically acceptable salt or solvate thereof.
2. The method according to method of claim 1 , wherein the dimer compound is in the form of a pharmaceutically acceptable salt.
3. The method of claim 1 wherein the composition is administered intramuscularly or subcutaneously.
4. The method of claim 1 wherein the compound is administered by subcutaneous depot injection.
5. The method of claim 1 , wherein the patient is a human and wherein the dose of dimer compound is administered is about 0.3 to about 1 mg.
6. The method of claim 4 wherein the dose of dimer compound is from about 5 to about 20 mgs.
7. The method of claim 4 wherein the dose of dimer compound is from about 20 to about 80 mgs.
8. The method of claim 4 wherein the patient suffered from diabetic neuropathic pain.
9. The method of claim 4 wherein the patient suffers from post herpetic neuropathic pain.