IP Library Granted Patent US 9,753,047
Granted Patent B2
US 9,753,047 · App. 14/922,892 · Granted Sep 5, 2017

Rotating sample positioning apparatus

Inventors: Christopher Cooney (Severn, MD); Alexander Perov (Germantown, MD); Arial Bueno (Frederick, MD); Charles Daitch (New Market, MD)
Assignee: AKONNI BIOSYSTEMS INC.
G01N35/025G01N35/00029G01N21/6452G01N21/6458G01N2035/00158G01N2035/00346G01N2035/00495G01N2035/00534G01N2035/0446G01N2035/0449G01N2035/0465
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Quick Facts
Patent No.
US 9,753,047
App. No.
14/922,892
Granted
Sep 5, 2017
Kind
B2
Abstract

A positioning system for a sample analysis device is disclosed. The positioning system comprises (1) a carousel comprising a platform and a sample loading tray mounted on the platform, and (2) a stage comprising a positioning system for positioning the carousel under the optical path of an imaging system. The sample loading tray is configured for holding a cartridge comprising one or more lateral flow cells (LFCs).

Claims (19)

1. A positioning system for a sample analysis device, comprising:

a carousel comprising a platform and a sample loading tray mounted on the platform wherein the sample loading tray is configured for holding a cartridge comprising one or more lateral flow cells, wherein the one or more lateral flow cells (LFCs) include a reaction chamber in fluid communication with a waste chamber, the waste chamber includes a liquid-retaining absorbent; and

a stage comprising a positioning system for positioning said carousel, wherein the carousel is rotatable relative to the stage;

wherein the rotation of the carousel produces centrifugal forces sufficient to drive water droplets from the reaction chamber in the LFCs toward the liquid-retaining absorbent in the waste chamber; and

wherein the carousel further comprises a clamp comprising a top bar, a bottom bar, and at least one supporting rod connecting the top bar and the bottom bar, wherein the platform and the sample loading tray are disposed between the top bar and the bottom bar of the clamp, wherein the clamp is movable relative to the platform and configured to secure the cartridge in the sample loading tray when the clamp is moved to a lock position,

wherein the bottom side of the carousel comprises a magnet that facilitates movement of the clamp.

2. The positioning system of claim 1 , wherein the carousel further comprises a handle configured to manually rotate the carousel.

3. The system of claim 1 , wherein the stage further comprises a positioning system for X, Y and Z axis positioning, and angular adjustment of the carousel.

4. The system of claim 1 , further comprises a heating and cooling device that is capable of heating and cooling the LFCs in the cartridge.

5. The system of claim 4 , wherein the heating and cooling device is configured to allow real-time monitoring of a biochemical amplification reaction within a reaction chamber of an LFC of the cartridge by an imaging device.

6. The system of claim 1 , wherein the carousel is movable to a reaction position to bring the cartridge into contact with a heating and cooling device to facilitate reactions in a reaction chamber of an LFC within the cartridge.

7. A positioning system for a microarray imaging device, comprising:

a carousel comprising a platform and a sample loading tray mounted on the platform wherein the sample loading tray is configured for holding a cartridge comprising one or more lateral flow cells, wherein the one or more lateral flow cells (LFCs) include a reaction chamber in fluid communication with a waste chamber, the waste chamber includes a liquid-retaining absorbent; and

a stage comprising a positioning system for X, Y, Z axis positioning said carousel, wherein the carousel is rotatable relative to the stage;

wherein the rotation of the carousel produces centrifugal forces sufficient to drive water droplets from the reaction chamber in the LFCs toward the liquid-retaining absorbent in the waste chamber; and

wherein the carousel further comprises a clamp comprising a top bar, a bottom bar, and at least one supporting rod connecting the top bar and the bottom bar, wherein the platform and the sample loading tray are disposed between the top bar and the bottom bar of the clamp, wherein the clamp is movable relative to the platform and configured to secure the cartridge in the sample loading tray when the clamp is moved to a lock position,

wherein the bottom side of the carousel comprises a magnet that facilitates movement of the clamp.

8. The positioning system of claim 7 , wherein the carousel further comprises a handle configured to manually rotate the carousel.

9. The system of claim 7 , wherein positioning system of the stage further allows for angular adjustment of the stage.

Assignments (6)
AMENDED AND RESTATED SECURITY AGREEMENT Recorded May 27, 2025
From: AKONNI BIOSYSTEMS, INC.
To: FIRESTONE, LAWRENCE
Reel/Frame 071394/0594 →
SECURITY INTEREST Recorded Jun 6, 2019
From: AKONNI BIOSYSTEMS, INC.
To: ROSENBLUM, RICHARD
Reel/Frame 049390/0037 →
RELEASE OF SECURITY INTEREST Recorded Feb 14, 2018
From: ROSENBLUM, RICHARD
To: AKONNI BIOSYSTEMS, INC.
Reel/Frame 044929/0984 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 2, 2017
From: DING, JIEN
To: E.P.C. (BEIJING) PLANT PHARMACEUTICAL TECHNOLOGY COMPANY, LTD.
Reel/Frame 043175/0740 →
SECURITY INTEREST Recorded Mar 15, 2017
From: AKONNI BIOSYSTEMS, INC.
To: ROSENBLUM, RICHARD
Reel/Frame 041582/0144 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 3, 2016
From: COONEY, CHRISTOPHER; PEROV, ALEXANDER; BUENO, ARIAL; DAITCH, CHARLES
To: AKONNI BIOSYSTEMS, INC.
Reel/Frame 037886/0530 →
Continuity (2)
Provisional Application 62069112 · Oct 27, 2014
Related Publication 20160116495A1 · Apr 28, 2016