Nutritionally enhanced fraction from rice bran and method of lowering insulin resistance using same
Nutritionally enhanced nutraceutical Hydrophilic and Lipophilic Rice Bran Fractions from rice bran are provided, as well as a method of using the same to reduce Insulin Resistance in animals, especially humans with pre-diabetes and Type 2 diabetes or others with symptoms of Metabolic Syndrome. Provided in various example embodiments are mixtures of elevated levels of nutraceutical compounds, including but not limited to gamma-oryzanol, inositol, ferulic acid, tocotrienols and phytosterols and pharmaceutical and nutritional compositions thereof. Steps are provided including evaluating insulin resistance parameters, initiating therapy including providing therapeutic amounts of Hydrophilic and Lipophilic Rice Bran Fractions from rice bran to treat pre-diabetes and Type 2 diabetes or others with symptoms of Metabolic Syndrome, managing compliance with the therapy, and monitoring and reevaluating the therapy.
1. A method of treating Insulin Resistance in a user, comprising the steps of: obtaining a nutraceutical comprising a hydrophilic and lipophilic rice bran fraction prepared by an enzyme treatment comprising the use of a beta-glucanase enzyme, a thermotolerant protease enzyme mix derived from Carica papaya, and a thermostable alpha-amylase enzyme; and administering the nutraceutical to the user for a minimum of 90 days in an amount sufficient to treat Insulin Resistance in the user; wherein said fraction has a total Oxygen Radical Absorbance Capacity of at least 20,500 micromoles Trolox equivalents per 100 grams of said fraction, at least 10 milligrams of tocotrienols per 100 grams of said fraction, at least 149 milligrams of inositol per 100 grams of said fraction, and at least 248 milligrams of gamma-oryzanol per 100 grams of said fraction, 5-50 mg ferulic acid, and at least four phytosterols comprising β-Sitosterol, Stigmasterol, Campesterol, and Brassicasterol, and wherein said user has a fasting glucose level of between 100 to 120 mg/dL, triglycerides above 150 mg/dL, and a blood pressure above 130/85 mmHg, and wherein said phytosterols obtained from the species Oryza sativa or Oryza glaberrima.
2. The method of claim 1 , wherein: the nutraceutical further comprises two or more of any of the following: Alpha lipoic acid; Coenzyme Q; Vitamin C; Vitamin E; Selenium; Chromium; Zinc; Chromium; Boron; Carnitine; Vitamin B3; Vitamin B12; Biotin; Folate; Vitamin B6; Vitamin B5; Vitamin 0; Vitamin K; Calcium; Potassium; Magnesium; Ginseng; Bilberry; Ginkgo biloba; Garlic; Onions.