IP Library › Granted Patent US 10,336,787
Granted Patent B2
US 10,336,787 · App. 14/932,231 · Granted Jul 2, 2019

Progesterone analogs and uses related thereto

Inventors: David B Guthrie (Avondale Estates, GA); Mark A Lockwood (Johns Creek, GA); Dennis C. Liotta (Atlanta, GA); Michael G Natchus (Alpharetta, GA); Donald G. Stein (Atlanta, GA); Iqbal Sayeed (Atlanta, GA)
Assignee: Emory University
C07J41/005A61K31/57A61K31/58A61K45/06C07J41/0016C07J43/003Y02A50/401
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Quick Facts
Patent No.
US 10,336,787
App. No.
14/932,231
Granted
Jul 2, 2019
Kind
B2
Abstract

This disclosure relates to progesterone derivatives and uses related thereto. In certain embodiments, the disclosure relates to compounds disclosed herein and uses for managing inflammation resulting from traumatic brain injury or stroke.

Claims (9)

1. A method of treating stroke or traumatic brain injury comprising administering an effective amount of a pharmaceutical composition comprising a compound of Formula II

or salts thereof to a subject in need thereof, wherein

R is selected from H, Me, Et,

2. The method of claim 1 , wherein the pharmaceutical composition is administered to a subject after a traumatic brain injury.

3. The method of claim 1 , wherein the pharmaceutical composition is administered to a subject after a stroke.

4. The method of claim 1 , wherein the pharmaceutical composition is administered in combination with a second active therapeutic agent.

5. A compound of Formula II

or salts thereof, wherein

R is selected from

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 20, 2019
From: GUTHRIE, DAVID B; LOCKWOOD, MARK A; LIOTTA, DENNIS C.; NATCHUS, MICHAEL G; STEIN, DONALD G.; SAYEED, IQBAL
To: EMORY UNIVERSITY
Reel/Frame 049229/0140 →
Continuity (3)
Continuation 13767106 · Feb 14, 2013
Provisional Application 61599079 · Feb 15, 2012
Related Publication 20160052957A1 · Feb 25, 2016
Cited By (1)
US 12,459,970