Organic electroluminescent materials and devices
Imidazophenanthridine ligands and metal complexes are provided. The compounds exhibit improved stability through a linking substitution that links a nitrogen bonded carbon of an imidizole ring to a carbon on the adjacent fused aryl ring. The compounds may be used in organic light emitting devices, particularly as emissive dopants, providing devices with improved efficiency, stability, and manufacturing. In particular, the compounds provided herein may be used in blue devices having high efficiency.
1. A compound having a structure (L A ) n ML m according to Formula 1:
wherein M is a metal having an atomic weight greater than 40, n has a value of at least 1 and m+n is the maximum number of ligands that may be attached to the metal;
wherein A is a linking group selected from the group consisting of CR′R″CR′R″—, —CR′R′—CR″R″—, —CH 2 —CH 2 —, —CR′R′—CR′R′—CR′R′—, —CR′R″—NR′—, —CR′═CR′—CR′R′—, —O—SiR′R′—, —CR′R″—S—, —CR′R″—O—, and —CR′R″—SiR′R′—,
wherein each R′ is independently selected from the group consisting of H, D, alkyl, cycloalkyl, aryl, heteroaryl, and combinations thereof,
wherein each R″ is independently selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, and combinations thereof,
wherein R′s and R″s are optionally connected to form a saturated five membered ring or a saturated six membered ring, and combinations thereof,
wherein R 1a to R 1g are each independently selected from the group consisting of hydrogen, deuterium, alkyl, cycloalkyl, heteroalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aralkyl, CN, CF 3 , CO 2 R, C(O)R, C(O)NR 2 , NR 2 , NO 2 , OR, SR, SO 2 , SOR, SO 3 R, halo, aryl, heteroaryl, a heterocyclic group, and combinations thereof;
wherein each R is independently selected from the group consisting of hydrogen, deuterium, halo, alkyl, cycloalkyl, heteroalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aralkyl, aryl, heteroaryl, and combinations thereof,
wherein any one of the ring atoms to which R 1b to R 1g are attached may be replaced with a nitrogen atom, wherein when the ring atom is replaced with a nitrogen atom the corresponding R group is not present;
wherein L is a substituted or unsubstituted cyclometallated ligand, wherein L can be joined to R 1g through a linking group L 2 ;
wherein L 2 is selected from the group consisting of a single bond, BR, NR, PR, O, S, Se, C—O, S—O, SO 2 , CR 1 R 2 , SiR′R 2 , and GeR 1 R 2 ,
wherein R 1 and R 2 can be same or different, and are independently selected from the group consisting of hydrogen, deuterium, alkyl, cycloalkyl, aryl, heteroaryl, and combinations thereof;
wherein any adjacent R 1 and R 2 are optionally connected to form a saturated five membered ring or a saturated six membered ring.
2. The compound of claim 1 , wherein the compound has a triplet excited state and wherein the linking group stabilizes the bond between N 2 and C 1b from cleavage when the compound is in the triplet excited state.
3. The compound of claim 1 , wherein the linking group is selected from the group consisting of:
4. The compound of claim 1 , wherein A is a saturated group.
5. The compound of claim 1 , wherein at least one of R 1a to R 1g is selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, partially or fully deuterated variants thereof, and combinations thereof.
6. The compound of claim 1 , wherein the metal is selected from the group consisting of Re, Ru, Os, Rh, Ir, Pd, Pt, and Au.
7. The compound of claim 1 , wherein the ligand L A is selected from the group consisting of:
L A
Linker A
R 1a
R 1b
R 1c
R 1d
R 1e
R 1f
R 1g
L A 1 L A 2 L A 3 L A 4 L A 5 L A 6
H Me H H H H
H H Me H H H
H H H Me H H
H H H H Me H
H H H H H Me
H H H H H H
H H H H H H
L A 7
CD 3
H
H
H
H
H
H
L A 8
H
CD 3
H
H
H
H
H
L A 9
H
H
CD 3
H
H
H
H
L A 10
H
H
H
CD 3
H
H
H
L A 11
H
H
H
H
CD 3
H
H
L A 12
i Pr
H
H
H
H
H
H
L A 13
H
i Pr
H
H
H
H
H
L A 14
H
H
i Pr
H
H
H
H
L A 15
H
H
H
i Pr
H
H
H
L A 16
H
H
H
H
i Pr
H
H
L A 17
Ph
H
H
H
H
H
H
L A 18
H
Ph
H
H
H
H
H
L A 19
H
H
Ph
H
H
H
H
L A 20
H
H
H
Ph
H
H
H
L A 21
H
H
H
H
Ph
H
H
L A 22
Me
Me
H
H
H
H
H
L A 23
Me
H
Me
H
H
H
H
L A 24
Me
H
H
Me
H
H
H
L A 25
Me
H
H
H
Me
H
H
L A 26
Me
CD 3
H
H
H
H
H
L A 27
Me
H
CD 3
H
H
H
H
L A 28
Me
H
H
CD 3
H
H
H
L A 29
Me
H
H
H
CD 3
H
H
L A 30
Me
i Pr
H
H
H
H
H
L A 31
Me
H
i Pr
H
H
H
H
L A 32
Me
H
H
i Pr
H
H
H
L A 33
Me
H
H
H
i Pr
H
H
L A 34
Me
Ph
H
H
H
H
H
L A 35
Me
H
Ph
H
H
H
H
L A 36
Me
H
H
Ph
H
H
H
L A 37
Me
H
H
H
Ph
H
H
L A 38
CD 3
Me
H
H
H
H
H
L A 39
CD 3
H
Me
H
H
H
H
L A 40
CD 3
H
H
Me
H
H
H
L A 41
CD 3
H
H
H
Me
H
H
L A 42
CD 3
CD 3
H
H
H
H
H
L A 43
CD 3
H
CD 3
H
H
H
H
L A 44
CD 3
H
H
CD 3
H
H
H
L A 45
CD 3
H
H
H
CD 3
H
H
L A 46
CD 3
i Pr
H
H
H
H
H
L A 47
CD 3
H
i Pr
H
H
H
H
L A 48
CD 3
H
H
i Pr
H
H
H
L A 49
CD 3
H
H
H
i Pr
H
H
L A 50
CD 3
Ph
H
H
H
H
H
L A 51
CD 3
H
Ph
H
H
H
H
L A 52 L A 53 L A 54 L A 55 L A 56 L A 57
CD 3 CD 3 i Pr i Pr i Pr i Pr
H H Me H H H
H H H Me H H
Ph H H H Me H
H Ph H H H Me
H H H H H H
H H H H H H
L A 58
i Pr
CD 3
H
H
H
H
H
L A 59
i Pr
H
CD 3
H
H
H
H
L A 60
i Pr
H
H
CD 3
H
H
H
L A 61
i Pr
H
H
H
CD 3
H
H
L A 62
i Pr
i Pr
H
H
H
H
H
L A 63
i Pr
H
i Pr
H
H
H
H
L A 64
i Pr
H
H
i Pr
H
H
H
L A 65
i Pr
H
H
H
i Pr
H
H
L A 66
i Pr
Ph
H
H
H
H
H
L A 67
i Pr
H
Ph
H
H
H
H
L A 68
i Pr
H
H
Ph
H
H
H
L A 69
i Pr
H
H
H
Ph
H
H
L A 70
Ph
Me
H
H
H
H
H
L A 71
Ph
H
Me
H
H
H
H
L A 72
Ph
H
H
Me
H
H
H
L A 73
Ph
H
H
H
Me
H
H
L A 74
Ph
CD 3
H
H
H
H
H
L A 75
Ph
H
CD 3
H
H
H
H
L A 76
Ph
H
H
CD 3
H
H
H
L A 77
Ph
H
H
H
CD 3
H
H
L A 78
Ph
i Pr
H
H
H
H
H
L A 79
Ph
H
i Pr
H
H
H
H
L A 80
Ph
H
H
i Pr
H
H
H
L A 81
Ph
H
H
H
i Pr
H
H
L A 82
Ph
Ph
H
H
H
H
H
L A 83
Ph
H
Ph
H
H
H
H
L A 84
Ph
H
H
Ph
H
H
H
L A 85
Ph
H
H
H
Ph
H
H
L A 86
H
Me
Me
H
H
H
H
L A 87
H
Me
H
Me
H
H
H
L A 88
H
Me
H
H
Me
H
H
L A 89
H
Me
CD 3
H
H
H
H
L A 90
H
Me
H
CD 3
H
H
H
L A 91
H
Me
H
H
CD 3
H
H
L A 92
H
Me
i Pr
H
H
H
H
L A 93
H
Me
H
i Pr
H
H
H
L A 94
H
Me
H
H
i Pr
H
H
L A 95
H
Me
Ph
H
H
H
H
L A 96
H
Me
H
Ph
H
H
H
L A 97
H
Me
H
H
Ph
H
H
L A 98
H
CD 3
Me
H
H
H
H
L A 99
H
CD 3
H
Me
H
H
H
L A 100
H
CD 3
H
H
Me
H
H
L A 101
H
CD 3
CD 3
H
H
H
H
L A 102
H
CD 3
H
CD 3
H
H
H
L A 103 L A 104 L A 105 L A 106 L A 107 L A 108
H H H H H H
CD 3 CD 3 CD 3 CD 3 CD 3 CD 3
H i Pr H H Ph H
H H i Pr H H Ph
CD 3 H H i Pr H H
H H H H H H
H H H H H H
L A 109
H
CD 3
H
H
Ph
H
H
L A 110
H
i Pr
Me
H
H
H
H
L A 111
H
i Pr
H
Me
H
H
H
L A 112
H
i Pr
H
H
Me
H
H
L A 113
H
i Pr
CD 3
H
H
H
H
L A 114
H
i Pr
H
CD 3
H
H
H
L A 115
H
i Pr
H
H
CD 3
H
H
L A 116
H
i Pr
i Pr
H
H
H
H
L A 117
H
i Pr
H
i Pr
H
H
H
L A 118
H
i Pr
H
H
i Pr
H
H
L A 119
H
i Pr
Ph
H
H
H
H
L A 120
H
i Pr
H
Ph
H
H
H
L A 121
H
i Pr
H
H
Ph
H
H
L A 122
H
Ph
Me
H
H
H
H
L A 123
H
Ph
H
Me
H
H
H
L A 124
H
Ph
H
H
Me
H
H
L A 125
H
Ph
CD 3
H
H
H
H
L A 126
H
Ph
H
CD 3
H
H
H
L A 127
H
Ph
H
H
CD 3
H
H
L A 128
H
Ph
i Pr
H
H
H
H
L A 129
H
Ph
H
i Pr
H
H
H
L A 130
H
Ph
H
H
i Pr
H
H
L A 131
H
Ph
Ph
H
H
H
H
L A 132
H
Ph
H
Ph
H
H
H
L A 133
H
Ph
H
H
Ph
H
H
L A 134
H
H
Me
Me
H
H
H
L A 135
H
H
CD 3
Me
H
H
H
L A 136
H
H
i Pr
Me
H
H
H
L A 137
H
H
Ph
Me
H
H
H
L A 138
H
H
Me
CD 3
H
H
H
L A 139
H
H
CD 3
CD 3
H
H
H
L A 140
H
H
i Pr
CD 3
H
H
H
L A 141
H
H
Ph
CD 3
H
H
H
L A 142
H
H
Me
i Pr
H
H
H
L A 143
H
H
CD 3
i Pr
H
H
H
L A 144
H
H
i Pr
i Pr
H
H
H
L A 145
H
H
Ph
i Pr
H
H
H
L A 146
H
H
Me
Ph
H
H
H
L A 147
H
H
CD 3
Ph
H
H
H
L A 148
H
H
i Pr
Ph
H
H
H
L A 149
H
H
Ph
Ph
H
H
H
L A 150
H
H
Me
H
Me
H
H
L A 151
H
H
CD 3
H
Me
H
H
L A 152
H
H
i Pr
H
Me
H
H
L A 153
H
H
Ph
H
Me
H
H
L A 154
H
H
Me
H
CD 3
H
H
L A 155
H
H
CD 3
H
CD 3
H
H
L A 156
H
H
i Pr
H
CD 3
H
H
L A 157
H
H
Ph
H
CD 3
H
H
L A 158 L A 159 L A 150 L A 161 L A 162 L A 163
H H H H H H
H H H H H H
Me CD 3 i Pr Ph Me CD 3
H H H H H H
i Pr i Pr i Pr i Pr Ph Ph
H H H H H H
H H H H H H
L A 164
H
H
i Pr
H
Ph
H
H
L A 165
H
H
Ph
H
Ph
H
H
L A 166
Me
Me
H
Me
H
H
H
L A 167
H
Me
Me
Me
H
H
H
L A 168
CD 3
Me
H
Me
H
H
H
L A 169
.H
Me
CD 3
Me
H
H
H
L A 170
i Pr
Me
H
Me
H
H
H
L A 171
H
Me
i Pr
Me
H
H
H
L A 172
Ph
Me
H
Me
H
H
H
L A 173
H
Me
Ph
Me
H
H
H
L A 174
Me
CD 3
H
CD 3
H
H
H
L A 175
H
CD 3
Me
CD 3
H
H
H
L A 176
CD 3
CD 3
H
CD 3
H
H
H
L A 177
H
CD 3
CD 3
CD 3
H
H
H
L A 178
i Pr
CD 3
H
CD 3
H
H
H
L A 179
H
CD 3
i Pr
CD 3
H
H
H
L A 180
Ph
CD 3
H
CD 3
H
H
H
L A 181
H
CD 3
Ph
CD 3
H
H
H
L A 182
Me
i Pr
H
i Pr
H
H
H
L A 183
H
i Pr
Me
i Pr
H
H
H
L A 184
CD 3
i Pr
H
i Pr
H
H
H
L A 185
H
i Pr
CD 3
i Pr
H
H
H
L A 186
i Pr
i Pr
H
i Pr
H
H
H
L A 187
H
i Pr
i Pr
i Pr
H
H
H
L A 188
Ph
i Pr
H
i Pr
H
H
H
L A 189
H
i Pr
Ph
i Pr
H
H
H
L A 190
Me
Ph
H
Ph
H
H
H
L A 191
H
Ph
Me
Ph
H
H
H
L A 192
CD 3
Ph
H
Ph
H
H
H
L A 193
H
Ph
CD 3
Ph
H
H
H
L A 194
i Pr
Ph
H
Ph
H
H
H
L A 195
H
Ph
i Pr
Ph
H
H
H
L A 196
Ph
Ph
H
Ph
H
H
H
L A 197
H
Ph
Ph
Ph
H
H
H
L A 198 L A 199 L A 200 L A 201 L A 202 L A 203
H Me H H H H
H H Me H H H
H H H Me H H
H H H H Me H
H H H H H Me
H H H H H H
H H H H H H
L A 204
CD 3
H
H
H
H
H
H
L A 205
H
CD 3
H
H
H
H
H
L A 206
H
H
CD 3
H
H
H
H
L A 207
H
H
H
CD 3
H
H
H
L A 208
H
H
H
H
CD 3
H
H
L A 209
i Pr
H
H
H
H
H
H
L A 210
H
i Pr
H
H
H
H
H
L A 211
H
H
i Pr
H
H
H
H
L A 212
H
H
H
i Pr
H
H
H
L A 213 L A 214 L A 215 L A 216 L A 217 L A 218
H Ph H H H H
H H Ph H H H
H H H Ph H H
H H H H Ph H
i Pr H H H H Ph
H H H H H H
H H H H H H
L A 219
Me
Me
H
H
H
H
H
L A 220
Me
H
Me
H
H
H
H
L A 221
Me
H
H
Me
H
H
H
L A 222
Me
H
H
H
Me
H
H
L A 223
Me
CD 3
H
H
H
H
H
L A 224
Me
H
CD 3
H
H
H
H
L A 225
Me
H
H
CD 3
H
H
H
L A 226
Me
H
H
H
CD 3
H
H
L A 227
Me
i Pr
H
H
H
H
H
L A 228
Me
H
i Pr
H
H
H
H
L A 229
Me
H
H
i Pr
H
H
H
L A 230
Me
H
H
H
i Pr
H
H
L A 231
Me
Ph
H
H
H
H
H
L A 232
Me
H
Ph
H
H
H
H
L A 233
Me
H
H
Ph
H
H
H
L A 234
Me
H
H
H
Ph
H
H
L A 235
CD 3
Me
H
H
H
H
H
L A 236
CD 3
H
Me
H
H
H
H
L A 237
CD 3
H
H
Me
H
H
H
L A 238
CD 3
H
H
H
Me
H
H
L A 239
CD 3
CD 3
H
H
H
H
H
L A 240
CD 3
H
CD 3
H
H
H
H
L A 241
CD 3
H
H
CD 3
H
H
H
L A 242
CD 3
H
H
H
CD 3
H
H
L A 243
CD 3
i Pr
H
H
H
H
H
L A 244
CD 3
H
i Pr
H
H
H
H
L A 245
CD 3
H
H
i Pr
H
H
H
L A 246
CD 3
H
H
H
i Pr
H
H
L A 247
CD 3
Ph
H
H
H
H
H
L A 248
CD 3
H
Ph
H
H
H
H
L A 249
CD 3
H
H
Ph
H
H
H
L A 250
CD 3
H
H
H
Ph
H
H
L A 251
i Pr
Me
H
H
H
H
H
L A 252
i Pr
H
Me
H
H
H
H
L A 253
i Pr
H
H
Me
H
H
H
L A 254
i Pr
H
H
H
Me
H
H
L A 255
i Pr
CD 3
H
H
H
H
H
L A 256
i Pr
H
CD 3
H
H
H
H
L A 257
i Pr
H
H
CD 3
H
H
H
L A 258
i Pr
H
H
H
CD 3
H
H
L A 259
i Pr
i Pr
H
H
H
H
H
L A 260
i Pr
H
i Pr
H
H
H
H
L A 261
i Pr
H
H
i Pr
H
H
H
L A 262
i Pr
H
H
H
i Pr
H
H
L A 263
i Pr
Ph
H
H
H
H
H
L A 264
i Pr
H
Ph
H
H
H
H
L A 265
i Pr
H
H
Ph
H
H
H
L A 266
i Pr
H
H
H
Ph
H
H
L A 267
Ph
Me
H
H
H
H
H
L A 268 L A 269 L A 270 L A 271 L A 272 L A 273
Ph Ph Ph Ph Ph Ph
H H H CD 3 H H
Me H H H CD 3 H
H Me H H H CD 3
H H Me H H H
H H H H H H
H H H H H H
L A 274
Ph
H
H
H
CD 3
H
H
L A 275
Ph
i Pr
H
H
H
H
H
L A 276
Ph
H
i Pr
H
H
H
H
L A 277
Ph
H
H
i Pr
H
H
H
L A 278
Ph
H
H
H
i Pr
H
H
L A 279
Ph
Ph
H
H
H
H
H
L A 280
Ph
H
Ph
H
H
H
H
L A 281
Ph
H
H
Ph
H
H
H
L A 282
Ph
H
H
H
Ph
H
H
L A 283
H
Me
Me
H
H
H
H
L A 284
H
Me
H
Me
H
H
H
L A 285
H
Me
H
H
Me
H
H
L A 286
H
Me
CD 3
H
H
H
H
L A 287
H
Me
H
CD 3
H
H
H
L A 288
H
Me
H
H
CD 3
H
H
L A 289
H
Me
i Pr
H
H
H
H
L A 290
H
Me
H
i Pr
H
H
H
L A 291
H
Me
H
H
i Pr
H
H
L A 292
H
Me
Ph
H
H
H
H
L A 293
H
Me
H
Ph
H
H
H
L A 294
H
Me
H
H
Ph
H
H
L A 295
H
CD 3
Me
H
H
H
H
L A 296
H
CD 3
H
Me
H
H
H
L A 297
H
CD 3
H
H
Me
H
H
L A 298
H
CD 3
CD 3
H
H
H
H
L A 299
H
CD 3
H
CD 3
H
H
H
L A 300
H
CD 3
H
H
CD 3
H
H
L A 301
H
CD 3
i Pr
H
H
H
H
L A 302
H
CD 3
H
i Pr
H
H
H
L A 303
H
CD 3
H
H
i Pr
H
H
L A 304
H
CD 3
Ph
H
H
H
H
L A 305
H
CD 3
H
Ph
H
H
H
L A 306
H
CD 3
H
H
Ph
H
H
L A 307
H
i Pr
Me
H
H
H
H
L A 308
H
i Pr
H
Me
H
H
H
L A 309
H
i Pr
H
H
Me
H
H
L A 310
H
i Pr
CD 3
H
H
H
H
L A 311
H
i Pr
H
CD 3
H
H
H
L A 312
H
i Pr
H
H
CD 3
H
H
L A 313
H
i Pr
i Pr
H
H
H
H
L A 314
H
i Pr
H
i Pr
H
H
H
L A 315
H
i Pr
H
H
i Pr
H
H
L A 316
H
i Pr
Ph
H
H
H
H
L A 317
H
i Pr
H
Ph
H
H
H
L A 318
H
i Pr
H
H
Ph
H
H
L A 319
H
Ph
Me
H
H
H
H
L A 320
H
Ph
H
Me
H
H
H
L A 321
H
Ph
H
H
Me
H
H
L A 322
H
Ph
CD 3
H
H
H
H
L A 323 L A 324 L A 325 L A 326 L A 327 L A 328
H H H H H H
Ph Ph Ph Ph Ph Ph
H H i Pr H H Ph
CD 3 H H i Pr H H
H CD 3 H H i Pr H
H H H H H H
H H H H H H
L A 329
H
Ph
H
Ph
H
H
H
L A 330
H
Ph
H
H
Ph
H
H
L A 331
H
H
Me
Me
H
H
H
L A 332
H
H
CD 3
Me
H
H
H
L A 333
H
H
i Pr
Me
H
H
H
L A 334
H
H
Ph
Me
H
H
H
L A 335
H
H
Me
CD 3
H
H
H
L A 336
H
H
CD 3
CD 3
H
H
H
L A 337
H
H
i Pr
CD 3
H
H
H
L A 338
H
H
Ph
CD 3
H
H
H
L A 339
H
H
Me
i Pr
H
H
H
L A 340
H
H
CD 3
i Pr
H
H
H
L A 341
H
H
i Pr
i Pr
H
H
H
L A 342
H
H
Ph
i Pr
H
H
H
L A 343
H
H
Me
Ph
H
H
H
L A 344
H
H
CD 3
Ph
H
H
H
L A 345
H
H
i Pr
Ph
H
H
H
L A 346
H
H
Ph
Ph
H
H
H
L A 347
H
H
Me
H
Me
H
H
L A 348
H
H
CD 3
H
Me
H
H
L A 349
H
H
i Pr
H
Me
H
H
L A 350
H
H
Ph
H
Me
H
H
L A 351
H
H
Me
H
CD 3
H
H
L A 352
H
H
CD 3
H
CD 3
H
H
L A 353
H
H
i Pr
H
CD 3
H
H
L A 354
H
H
Ph
H
CD 3
H
H
L A 355
H
H
Me
H
i Pr
H
H
L A 356
H
H
CD 3
H
i Pr
H
H
L A 357
H
H
i Pr
H
i Pr
H
H
L A 358
H
H
Ph
H
i Pr
H
H
L A 359
H
H
Me
H
Ph
H
H
L A 360
H
H
CD 3
H
Ph
H
H
L A 361
H
H
i Pr
H
Ph
H
H
L A 362
H
H
Ph
H
Ph
H
H
L A 363
Me
Me
H
Me
H
H
H
L A 364
H
Me
Me
Me
H
H
H
L A 365
CD 3
Me
H
Me
H
H
H
L A 366
H
Me
CD 3
Me
H
H
H
L A 367
i Pr
Me
H
Me
H
H
H
L A 368
H
Me
i Pr
Me
H
H
H
L A 369
Ph
Me
H
Me
H
H
H
L A 370
H
Me
Ph
Me
H
H
H
L A 371
Me
CD 3
H
CD 3
H
H
H
L A 372
H
CD 3
Me
CD 3
H
H
H
L A 373
CD 3
CD 3
H
CD 3
H
H
H
L A 374
H
CD 3
CD 3
CD 3
H
H
H
L A 375
i Pr
CD 3
H
CD 3
H
H
H
L A 376
H
CD 3
i Pr
CD 3
H
H
H
L A 377
Ph
CD 3
H
CD 3
H
H
H
L A 378 L A 379 L A 380 L A 381 L A 382 L A 383
H Me H CD 3 H i Pr
CD 3 i Pr i Pr i Pr i Pr i Pr
Ph H Me H CD 3 H
CD 3 i Pr i Pr i Pr i Pr i Pr
H H H H H H
H H H H H H
H H H H H H
L A 384
H
i Pr
i Pr
i Pr
H
H
H
L A 385
Ph
i Pr
H
i Pr
H
H
H
L A 386
H
i Pr
Ph
i Pr
H
H
H
L A 387
Me
Ph
H
Ph
H
H
H
L A 388
H
Ph
Me
Ph
H
H
H
L A 389
CD 3
Ph
H
Ph
H
H
H
L A 390
H
Ph
CD 3
Ph
H
H
H
L A 391
i Pr
Ph
H
Ph
H
H
H
L A 392
H
Ph
i Pr
Ph
H
H
H
L A 393
Ph
Ph
H
Ph
H
H
H
L A 394
H
Ph
Ph
Ph
H
H
H
L A 395 L A 396 L A 397 L A 398 L A 399 L A 400 L A 401 L A 402
H Me H H H H CD 3 H
H H Me H H H H CD 3
H H H Me H H H H
H H H H Me H H H
H H H H H Me H H
H H H H H H H H
H H H H H H H H
L A 403
H
H
CD 3
H
H
H
H
L A 404
H
H
H
CD 3
H
H
H
L A 405
H
H
H
H
CD 3
H
H
L A 406
i Pr
H
H
H
H
H
H
L A 407
H
i Pr
H
H
H
H
H
L A 408
H
H
i Pr
H
H
H
H
L A 409
H
H
H
i Pr
H
H
H
L A 410
H
H
H
H
i Pr
H
H
L A 411
Ph
H
H
H
H
H
H
L A 412
H
Ph
H
H
H
H
H
L A 413
H
H
Ph
H
H
H
H
L A 414
H
H
H
Ph
H
H
H
L A 415
H
H
H
H
Ph
H
H
L A 416
Me
Me
H
H
H
H
H
L A 417
Me
H
Me
H
H
H
H
L A 418
Me
H
H
Me
H
H
H
L A 419
Me
H
H
H
Me
H
H
L A 420
Me
CD 3
H
H
H
H
H
L A 421
Me
H
CD 3
H
H
H
H
L A 422
Me
H
H
CD 3
H
H
H
L A 423
Me
H
H
H
CD 3
H
H
L A 424
Me
i Pr
H
H
H
H
H
L A 425
Me
H
i Pr
H
H
H
H
L A 426
Me
H
H
i Pr
H
H
H
L A 427
Me
H
H
H
i Pr
H
H
L A 428
Me
Ph
H
H
H
H
H
L A 429
Me
H
Ph
H
H
H
H
L A 430
Me
H
H
Ph
H
H
H
L A 431
Me
H
H
H
Ph
H
H
L A 432
CD 3
Me
H
H
H
H
H
L A 433 L A 434 L A 435 L A 436 L A 437 L A 438 L A 439 L A 440
CD 3 CD 3 CD 3 CD 3 CD 3 CD 3 CD 3 CD 3
H H H CD 3 H H H i Pr
Me H H H CD 3 H H H
H Me H H H CD 3 H H
H H Me H H H CD 3 H
H H H H H H H H
H H H H H H H H
L A 441
CD 3
H
i Pr
H
H
H
H
L A 442
CD 3
H
H
i Pr
H
H
H
L A 443
CD 3
H
H
H
i Pr
H
H
L A 444
CD 3
Ph
H
H
H
H
H
L A 445
CD 3
H
Ph
H
H
H
H
L A 446
CD 3
H
H
Ph
H
H
H
L A 447
CD 3
H
H
H
Ph
H
H
L A 448
i Pr
Me
H
H
H
H
H
L A 449
i Pr
H
Me
H
H
H
H
L A 450
i Pr
H
H
Me
H
H
H
L A 451
i Pr
H
H
H
Me
H
H
L A 452
i Pr
CD 3
H
H
H
H
H
L A 453
i Pr
H
CD 3
H
H
H
H
L A 454
i Pr
H
H
CD 3
H
H
H
L A 455
i Pr
H
H
H
CD 3
H
H
L A 456
i Pr
i Pr
H
H
H
H
H
L A 457
i Pr
H
i Pr
H
H
H
H
L A 458
i Pr
H
H
i Pr
H
H
H
L A 459
i Pr
H
H
H
i Pr
H
H
L A 460
i Pr
Ph
H
H
H
H
H
L A 461
i Pr
H
Ph
H
H
H
H
L A 462
i Pr
H
H
Ph
H
H
H
L A 463
i Pr
H
H
H
Ph
H
H
L A 464
Ph
Me
H
H
H
H
H
L A 465
Ph
H
Me
H
H
H
H
L A 466
Ph
H
H
Me
H
H
H
L A 467
Ph
H
H
H
Me
H
H
L A 468
Ph
CD 3
H
H
H
H
H
L A 469
Ph
H
CD 3
H
H
H
H
L A 470
Ph
H
H
CD 3
H
H
H
L A 471
Ph
H
H
H
CD 3
H
H
L A 472
Ph
i Pr
H
H
H
H
H
L A 473
Ph
H
i Pr
H
H
H
H
L A 474
Ph
H
H
i Pr
H
H
H
L A 475
Ph
H
H
H
i Pr
H
H
L A 476
Ph
Ph
H
H
H
H
H
L A 477
Ph
H
Ph
H
H
H
H
L A 478
Ph
H
H
Ph
H
H
H
L A 479
Ph
H
H
H
Ph
H
H
L A 480
H
Me
Me
H
H
H
H
L A 481
H
Me
H
Me
H
H
H
L A 482
H
Me
H
H
Me
H
H
L A 483
H
Me
CD 3
H
H
H
H
L A 484
H
Me
H
CD 3
H
H
H
L A 485
H
Me
H
H
CD 3
H
H
L A 486
H
Me
i Pr
H
H
H
H
L A 487
H
Me
H
i Pr
H
H
H
L A 488 L A 489 L A 490 L A 491 L A 492 L A 493 L A 494 L A 495
H H H H H H H H
Me Me Me Me CD 3 CD 3 CD 3 CD 3
H Ph H H Me H H CD 3
H H Ph H H Me H H
i Pr H H Ph H H Me H
H H H H H H H H
H H H H H H H H
L A 496
H
CD 3
H
CD 3
H
H
H
L A 497
H
CD 3
H
H
CD 3
H
H
L A 498
H
CD 3
i Pr
H
H
H
H
L A 499
H
CD 3
H
i Pr
H
H
H
L A 500
H
CD 3
H
H
i Pr
H
H
L A 501
H
CD 3
Ph
H
H
H
H
L A 502
H
CD 3
H
Ph
H
H
H
L A 503
H
CD 3
H
H
Ph
H
H
L A 504
H
i Pr
Me
H
H
H
H
L A 505
H
i Pr
H
Me
H
H
H
L A 506
H
i Pr
H
H
Me
H
H
L A 507
H
i Pr
CD 3
H
H
H
H
L A 508
H
i Pr
H
CD 3
H
H
H
L A 509
H
i Pr
H
H
CD 3
H
H
L A 510
H
i Pr
i Pr
H
H
H
H
L A 511
H
i Pr
H
i Pr
H
H
H
L A 512
H
i Pr
H
H
i Pr
H
H
L A 513
H
i Pr
Ph
H
H
H
H
L A 514
H
i Pr
H
Ph
H
H
H
L A 515
H
i Pr
H
H
Ph
H
H
L A 516
H
Ph
Me
H
H
H
H
L A 517
H
Ph
H
Me
H
H
H
L A 518
H
Ph
H
H
Me
H
H
L A 519
H
Ph
CD 3
H
H
H
H
L A 520
H
Ph
H
CD 3
H
H
H
L A 521
H
Ph
H
H
CD 3
H
H
L A 522
H
Ph
i Pr
H
H
H
H
L A 523
H
Ph
H
i Pr
H
H
H
L A 524
H
Ph
H
H
i Pr
H
H
L A 525
H
Ph
Ph
H
H
H
H
L A 526
H
Ph
H
Ph
H
H
H
L A 527
H
Ph
H
H
Ph
H
H
L A 528
H
H
Me
Me
H
H
H
L A 529
H
H
CD 3
Me
H
H
H
L A 530
H
H
i Pr
Me
H
H
H
L A 531
H
H
Ph
Me
H
H
H
L A 532
H
H
Me
CD 3
H
H
H
L A 533
H
H
CD 3
CD 3
H
H
H
L A 534
H
H
i Pr
CD 3
H
H
H
L A 535
H
H
Ph
CD 3
H
H
H
L A 536
H
H
Me
i Pr
H
H
H
L A 537
H
H
CD 3
i Pr
H
H
H
L A 538
H
H
i Pr
i Pr
H
H
H
L A 539
H
H
Ph
i Pr
H
H
H
L A 540
H
H
Me
Ph
H
H
H
L A 541
H
H
CD 3
Ph
H
H
H
L A 542
H
H
i Pr
Ph
H
H
H
L A 543 L A 544 L A 545 L A 546 L A 547 L A 548 L A 549 L A 550
H H H H H H H H
H H H H H H H H
Ph Me CD 3 i Pr Ph Me CD 3 i Pr
Ph H H H H H H H
H Me Me Me Me CD 3 CD 3 CD 3
H H H H H H H H
H H H H H H H H
L A 551
H
H
Ph
H
CD 3
H
H
L A 552
H
H
Me
H
i Pr
H
H
L A 553
H
H
CD 3
H
i Pr
H
H
L A 554
H
H
i Pr
H
i Pr
H
H
L A 555
H
H
Ph
H
i Pr
H
H
L A 556
H
H
Me
H
Ph
H
H
L A 557
H
H
CD 3
H
Ph
H
H
L A 558
H
H
i Pr
H
Ph
H
H
L A 559
H
H
Ph
H
Ph
H
H
L A 560
Me
Me
H
Me
H
H
H
L A 561
H
Me
Me
Me
H
H
H
L A 562
CD 3
Me
H
Me
H
H
H
L A 563
H
Me
CD 3
Me
H
H
H
L A 564
i Pr
Me
H
Me
H
H
H
L A 565
H
Me
i Pr
Me
H
H
H
L A 566
Ph
Me
H
Me
H
H
H
L A 567
H
Me
Ph
Me
H
H
H
L A 568
Me
CD 3
H
CD 3
H
H
H
L A 569
H
CD 3
Me
CD 3
H
H
H
L A 570
CD 3
CD 3
H
CD 3
H
H
H
L A 571
H
CD 3
CD 3
CD 3
H
H
H
L A 572
i Pr
CD 3
H
CD 3
H
H
H
L A 573
H
CD 3
i Pr
CD 3
H
H
H
L A 574
Ph
CD 3
H
CD 3
H
H
H
L A 575
H
CD 3
Ph
CD 3
H
H
H
L A 576
Me
i Pr
H
i Pr
H
H
H
L A 577
H
i Pr
Me
i Pr
H
H
H
L A 578
CD 3
i Pr
H
i Pr
H
H
H
L A 579
H
i Pr
CD 3
i Pr
H
H
H
L A 580
i Pr
i Pr
H
i Pr
H
H
H
L A 581
H
i Pr
i Pr
i Pr
H
H
H
L A 582
Ph
i Pr
H
i Pr
H
H
H
L A 583
H
i Pr
Ph
i Pr
H
H
H
L A 584
Me
Ph
H
Ph
H
H
H
L A 585
H
Ph
Me
Ph
H
H
H
L A 586
CD 3
Ph
H
Ph
H
H
H
L A 587
H
Ph
CD 3
Ph
H
H
H
L A 588
i Pr
Ph
H
Ph
H
H
H
L A 589
H
Ph
i Pr
Ph
H
H
H
L A 590
Ph
Ph
H
Ph
H
H
H
L A 591
H
Ph
Ph
Ph
H
H
H
L A 592 L A 593 L A 594 L A 595 L A 596 L A 597
H Me H H H H
H H Me H H H
H H H Me H H
H H H H Me H
H H H H H Me
H H H H H H
H H H H H H
L A 598 L A 599 L A 600 L A 601 L A 602 L A 603
CD 3 H H H H i Pr
H CD 3 H H H H
H H CD 3 H H H
H H H CD 3 H H
H H H H CD 3 H
H H H H H H
H H H H H H
L A 604
H
i Pr
H
H
H
H
H
L A 605
H
H
i Pr
H
H
H
H
L A 606
H
H
H
i Pr
H
H
H
L A 607
H
H
H
H
i Pr
H
H
L A 608
Ph
H
H
H
H
H
H
L A 609
H
Ph
H
H
H
H
H
L A 610
H
H
Ph
H
H
H
H
L A 611
H
H
H
Ph
H
H
H
L A 612
H
H
H
H
Ph
H
H
L A 613
Me
Me
H
H
H
H
H
L A 614
Me
H
Me
H
H
H
H
L A 615
Me
H
H
Me
H
H
H
L A 616
Me
H
H
H
Me
H
H
L A 617
Me
CD 3
H
H
H
H
H
L A 618
Me
H
CD 3
H
H
H
H
L A 619
Me
H
H
CD 3
H
H
H
L A 620
Me
H
H
H
CD 3
H
H
L A 621
Me
i Pr
H
H
H
H
H
L A 622
Me
H
i Pr
H
H
H
H
L A 623
Me
H
H
i Pr
H
H
H
L A 624
Me
H
H
H
i Pr
H
H
L A 625
Me
Ph
H
H
H
H
H
L A 626
Me
H
Ph
H
H
H
H
L A 627
Me
H
H
Ph
H
H
H
L A 628
Me
H
H
H
Ph
H
H
L A 629
CD 3
Me
H
H
H
H
H
L A 630
CD 3
H
Me
H
H
H
H
L A 631
CD 3
H
H
Me
H
H
H
L A 632
CD 3
H
H
H
Me
H
H
L A 633
CD 3
CD 3
H
H
H
H
H
L A 634
CD 3
H
CD 3
H
H
H
H
L A 635
CD 3
H
H
CD 3
H
H
H
L A 636
CD 3
H
H
H
CD 3
H
H
L A 637
CD 3
i Pr
H
H
H
H
H
L A 638
CD 3
H
i Pr
H
H
H
H
L A 639
CD 3
H
H
i Pr
H
H
H
L A 640
CD 3
H
H
H
i Pr
H
H
L A 641
CD 3
Ph
H
H
H
H
H
L A 642
CD 3
H
Ph
H
H
H
H
L A 643
CD 3
H
H
Ph
H
H
H
L A 644
CD 3
H
H
H
Ph
H
H
L A 645
i Pr
Me
H
H
H
H
H
L A 646
i Pr
H
Me
H
H
H
H
L A 647
i Pr
H
H
Me
H
H
H
L A 648
i Pr
H
H
H
Me
H
H
L A 649
i Pr
CD 3
H
H
H
H
H
L A 650
i Pr
H
CD 3
H
H
H
H
L A 651
i Pr
H
H
CD 3
H
H
H
L A 652
i Pr
H
H
H
CD 3
H
H
L A 653 L A 654 L A 655 L A 656 L A 657 L A 658
i Pr i Pr i Pr i Pr i Pr i Pr
i Pr H H H Ph H
H i Pr H H H Ph
H H i Pr H H H
H H H i Pr H H
H H H H H H
H H H H H H
L A 659
i Pr
H
H
Ph
H
H
H
L A 660
i Pr
H
H
H
Ph
H
H
L A 661
Ph
Me
H
H
H
H
H
L A 662
Ph
H
Me
H
H
H
H
L A 663
Ph
H
H
Me
H
H
H
L A 664
Ph
H
H
H
Me
H
H
L A 665
Ph
CD 3
H
H
H
H
H
L A 666
Ph
H
CD 3
H
H
H
H
L A 667
Ph
H
H
CD 3
H
H
H
L A 668
Ph
H
H
H
CD 3
H
H
L A 669
Ph
i Pr
H
H
H
H
H
L A 670
Ph
H
i Pr
H
H
H
H
L A 671
Ph
H
H
i Pr
H
H
H
L A 672
Ph
H
H
H
i Pr
H
H
L A 673
Ph
Ph
H
H
H
H
H
L A 674
Ph
H
Ph
H
H
H
H
L A 675
Ph
H
H
Ph
H
H
H
L A 676
Ph
H
H
H
Ph
H
H
L A 677
H
Me
Me
H
H
H
H
L A 678
H
Me
H
Me
H
H
H
L A 679
H
Me
H
H
Me
H
H
L A 680
H
Me
CD 3
H
H
H
H
L A 681
H
Me
H
CD 3
H
H
H
L A 682
H
Me
H
H
CD 3
H
H
L A 683
H
Me
i Pr
H
H
H
H
L A 684
H
Me
H
i Pr
H
H
H
L A 685
H
Me
H
H
i Pr
H
H
L A 686
H
Me
Ph
H
H
H
H
L A 687
H
Me
H
Ph
H
H
H
L A 688
H
Me
H
H
Ph
H
H
L A 689
H
CD 3
Me
H
H
H
H
L A 690
H
CD 3
H
Me
H
H
H
L A 691
H
CD 3
H
H
Me
H
H
L A 692
H
CD 3
CD 3
H
H
H
H
L A 693
H
CD 3
H
CD 3
H
H
H
L A 694
H
CD 3
H
H
CD 3
H
H
L A 695
H
CD 3
i Pr
H
H
H
H
L A 696
H
CD 3
H
i Pr
H
H
H
L A 697
H
CD 3
H
H
i Pr
H
H
L A 698
H
CD 3
Ph
H
H
H
H
L A 699
H
CD 3
H
Ph
H
H
H
L A 700
H
CD 3
H
H
Ph
H
H
L A 701
H
i Pr
Me
H
H
H
H
L A 702
H
i Pr
H
Me
H
H
H
L A 703
H
i Pr
H
H
Me
H
H
L A 704
H
i Pr
CD 3
H
H
H
H
L A 705
H
i Pr
H
CD 3
H
H
H
L A 706
H
i Pr
H
H
CD 3
H
H
L A 707
H
i Pr
i Pr
H
H
H
H
L A 708 L A 709 L A 710 L A 711 L A 712 L A 713
H H H H H H
i Pr i Pr i Pr i Pr i Pr Ph
H H Ph H H Me
i Pr H H Ph H H
H i Pr H H Ph H
H H H H H H
H H H H H H
L A 714
H
Ph
H
Me
H
H
H
L A 715
H
Ph
H
H
Me
H
H
L A 716
H
Ph
CD 3
H
H
H
H
L A 717
H
Ph
H
CD 3
H
H
H
L A 718
H
Ph
H
H
CD 3
H
H
L A 719
H
Ph
i Pr
H
H
H
H
L A 720
H
Ph
H
i Pr
H
H
H
L A 721
H
Ph
H
H
i Pr
H
H
L A 722
H
Ph
Ph
H
H
H
H
L A 723
H
Ph
H
Ph
H
H
H
L A 724
H
Ph
H
H
Ph
H
H
L A 725
H
H
Me
Me
H
H
H
L A 726
H
H
CD 3
Me
H
H
H
L A 727
H
H
i Pr
Me
H
H
H
L A 728
H
H
Ph
Me
H
H
H
L A 729
H
H
Me
CD 3
H
H
H
L A 730
H
H
CD 3
CD 3
H
H
H
L A 731
H
H
i Pr
CD 3
H
H
H
L A 732
H
H
Ph
CD 3
H
H
H
L A 733
H
H
Me
i Pr
H
H
H
L A 734
H
H
CD 3
i Pr
H
H
H
L A 735
H
H
i Pr
i Pr
H
H
H
L A 736
H
H
Ph
i Pr
H
H
H
L A 737
H
H
Me
Ph
H
H
H
L A 738
H
H
CD 3
Ph
H
H
H
L A 739
H
H
i Pr
Ph
H
H
H
L A 740
H
H
Ph
Ph
H
H
H
L A 741
H
H
Me
H
Me
H
H
L A 742
H
H
CD 3
H
Me
H
H
L A 743
H
H
i Pr
H
Me
H
H
L A 744
H
H
Ph
H
Me
H
H
L A 745
H
H
Me
H
CD 3
H
H
L A 746
H
H
CD 3
H
CD 3
H
H
L A 747
H
H
i Pr
H
CD 3
H
H
L A 748
H
H
Ph
H
CD 3
H
H
L A 749
H
H
Me
H
i Pr
H
H
L A 750
H
H
CD 3
H
i Pr
H
H
L A 751
H
H
i Pr
H
i Pr
H
H
L A 752
H
H
Ph
H
i Pr
H
H
L A 753
H
H
Me
H
Ph
H
H
L A 754
H
H
CD 3
H
Ph
H
H
L A 755
H
H
i Pr
H
Ph
H
H
L A 756
H
H
Ph
H
Ph
H
H
L A 757
Me
Me
H
Me
H
H
H
L A 758
H
Me
Me
Me
H
H
H
L A 759
CD 3
Me
H
Me
H
H
H
L A 760
H
Me
CD 3
Me
H
H
H
L A 761
i Pr
Me
H
Me
H
H
H
L A 762
H
Me
i Pr
Me
H
H
H
L A 763 L A 764 L A 765 L A 766 L A 767 L A 768
Ph H Me H CD 3 H
Me Me CD 3 CD 3 CD 3 CD 3
H Ph H Me H CD 3
Me Me CD 3 CD 3 CD 3 CD 3
H H H H H H
H H H H H H
H H H H H H
L A 769
i Pr
CD 3
H
CD 3
H
H
H
L A 770
H
CD 3
i Pr
CD 3
H
H
H
L A 771
Ph
CD 3
H
CD 3
H
H
H
L A 772
H
CD 3
Ph
CD 3
H
H
H
L A 773
Me
i Pr
H
i Pr
H
H
H
L A 774
H
i Pr
Me
i Pr
H
H
H
L A 775
CD 3
i Pr
H
i Pr
H
H
H
L A 776
H
i Pr
CD 3
i Pr
H
H
H
L A 777
i Pr
i Pr
H
i Pr
H
H
H
L A 778
H
i Pr
i Pr
i Pr
H
H
H
L A 779
Ph
i Pr
H
i Pr
H
H
H
L A 780
H
i Pr
Ph
i Pr
H
H
H
L A 781
Me
Ph
H
Ph
H
H
H
L A 782
H
Ph
Me
Ph
H
H
H
L A 783
CD 3
Ph
H
Ph
H
H
H
L A 784
H
Ph
CD 3
Ph
H
H
H
L A 785
i Pr
Ph
H
Ph
H
H
H
L A 786
H
Ph
i Pr
Ph
H
H
H
L A 787
Ph
Ph
H
Ph
H
H
H
L A 788
H
Ph
Ph
Ph
H
H
H
L A 789 L A 790 L A 791 L A 792 L A 793 L A 794
H Me H H H H
H H Me H H H
H H H Me H H
H H H H Me H
H H H H H Me
H H H H H H
H H H H H H
L A 795
CD 3
H
H
H
H
H
H
L A 796
H
CD 3
H
H
H
H
H
L A 797
H
H
CD 3
H
H
H
H
L A 798
H
H
H
CD 3
H
H
H
L A 799
H
H
H
H
CD 3
H
H
L A 800
i Pr
H
H
H
H
H
H
L A 801
H
i Pr
H
H
H
H
H
L A 802
H
H
i Pr
H
H
H
H
L A 803
H
H
H
i Pr
H
H
H
L A 804
H
H
H
H
i Pr
H
H
L A 805
Ph
H
H
H
H
H
H
L A 806
H
Ph
H
H
H
H
H
L A 807
H
H
Ph
H
H
H
H
L A 808
H
H
H
Ph
H
H
H
L A 809
H
H
H
H
Ph
H
H
L A 810
Me
Me
H
H
H
H
H
L A 811
Me
H
Me
H
H
H
H
L A 812
Me
H
H
Me
H
H
H
L A 813
Me
H
H
H
Me
H
H
L A 814
Me
CD 3
H
H
H
H
H
L A 815
Me
H
CD 3
H
H
H
H
L A 816
Me
H
H
CD 3
H
H
H
L A 817
Me
H
H
H
CD 3
H
H
L A 818 L A 819 L A 820 L A 821 L A 822 L A 823
Me Me Me Me Me Me
i Pr H H H Ph H
H i Pr H H H Ph
H H i Pr H H H
H H H i Pr H H
H H H H H H
H H H H H H
L A 824
Me
H
H
Ph
H
H
H
L A 825
Me
H
H
H
Ph
H
H
L A 826
CD 3
Me
H
H
H
H
H
L A 827
CD 3
H
Me
H
H
H
H
L A 828
CD 3
H
H
Me
H
H
H
L A 829
CD 3
H
H
H
Me
H
H
L A 830
CD 3
CD 3
H
H
H
H
H
L A 831
CD 3
H
CD 3
H
H
H
H
L A 832
CD 3
H
H
CD 3
H
H
H
L A 833
CD 3
H
H
H
CD 3
H
H
L A 834
CD 3
i Pr
H
H
H
H
H
L A 835
CD 3
H
i Pr
H
H
H
H
L A 836
CD 3
H
H
i Pr
H
H
H
L A 837
CD 3
H
H
H
i Pr
H
H
L A 838
CD 3
Ph
H
H
H
H
H
L A 839
CD 3
H
Ph
H
H
H
H
L A 840
CD 3
H
H
Ph
H
H
H
L A 841
CD 3
H
H
H
Ph
H
H
L A 842
i Pr
Me
H
H
H
H
H
L A 843
i Pr
H
Me
H
H
H
H
L A 844
i Pr
H
H
Me
H
H
H
L A 845
i Pr
H
H
H
Me
H
H
L A 846
i Pr
CD 3
H
H
H
H
H
L A 847
i Pr
H
CD 3
H
H
H
H
L A 848
i Pr
H
H
CD 3
H
H
H
L A 849
i Pr
H
H
H
CD 3
H
H
L A 850
i Pr
i Pr
H
H
H
H
H
L A 851
i Pr
H
i Pr
H
H
H
H
L A 852
i Pr
H
H
i Pr
H
H
H
L A 853
i Pr
H
H
H
i Pr
H
H
L A 854
i Pr
Ph
H
H
H
H
H
L A 855
i Pr
H
Ph
H
H
H
H
L A 856
i Pr
H
H
Ph
H
H
H
L A 857
i Pr
H
H
H
Ph
H
H
L A 858
Ph
Me
H
H
H
H
H
L A 859
Ph
H
Me
H
H
H
H
L A 860
Ph
H
H
Me
H
H
H
L A 861
Ph
H
H
H
Me
H
H
L A 862
Ph
CD 3
H
H
H
H
H
L A 863
Ph
H
CD 3
H
H
H
H
L A 864
Ph
H
H
CD 3
H
H
H
L A 865
Ph
H
H
H
CD 3
H
H
L A 866
Ph
i Pr
H
H
H
H
H
L A 867
Ph
H
i Pr
H
H
H
H
L A 868
Ph
H
H
i Pr
H
H
H
L A 869
Ph
H
H
H
i Pr
H
H
L A 870
Ph
Ph
H
H
H
H
H
L A 871
Ph
H
Ph
H
H
H
H
L A 872
Ph
H
H
Ph
H
H
H
L A 873 L A 874 L A 875 L A 876 L A 877 L A 878
Ph H H H H H
H Me Me Me Me Me
H Me H H CD 3 H
H H Me H H CD 3
Ph H H Me H H
H H H H H H
H H H H H H
L A 879
H
Me
H
H
CD 3
H
H
L A 880
H
Me
i Pr
H
H
H
H
L A 881
H
Me
H
i Pr
H
H
H
L A 882
H
Me
H
H
i Pr
H
H
L A 883
H
Me
Ph
H
H
H
H
L A 884
H
Me
H
Ph
H
H
H
L A 885
H
Me
H
H
Ph
H
H
L A 886
H
CD 3
Me
H
H
H
H
L A 887
H
CD 3
H
Me
H
H
H
L A 888
H
CD 3
H
H
Me
H
H
L A 889
H
CD 3
CD 3
H
H
H
H
L A 890
H
CD 3
H
CD 3
H
H
H
L A 891
H
CD 3
H
H
CD 3
H
H
L A 892
H
CD 3
i Pr
H
H
H
H
L A 893
H
CD 3
H
i Pr
H
H
H
L A 894
H
CD 3
H
H
i Pr
H
H
L A 895
H
CD 3
Ph
H
H
H
H
L A 896
H
CD 3
H
Ph
H
H
H
L A 897
H
CD 3
H
H
Ph
H
H
L A 898
H
i Pr
Me
H
H
H
H
L A 899
H
i Pr
H
Me
H
H
H
L A 900
H
i Pr
H
H
Me
H
H
L A 901
H
i Pr
CD 3
H
H
H
H
L A 902
H
i Pr
H
CD 3
H
H
H
L A 903
H
i Pr
H
H
CD 3
H
H
L A 904
H
i Pr
i Pr
H
H
H
H
L A 905
H
i Pr
H
i Pr
H
H
H
L A 906
H
i Pr
H
H
i Pr
H
H
L A 907
H
i Pr
Ph
H
H
H
H
L A 908
H
i Pr
H
Ph
H
H
H
L A 909
H
i Pr
H
H
Ph
H
H
L A 910
H
Ph
Me
H
H
H
H
L A 911
H
Ph
H
Me
H
H
H
L A 912
H
Ph
H
H
Me
H
H
L A 913
H
Ph
CD 3
H
H
H
H
L A 914
H
Ph
H
CD 3
H
H
H
L A 915
H
Ph
H
H
CD 3
H
H
L A 916
H
Ph
i Pr
H
H
H
H
L A 917
H
Ph
H
i Pr
H
H
H
L A 918
H
Ph
H
H
i Pr
H
H
L A 919
H
Ph
Ph
H
H
H
H
L A 920
H
Ph
H
Ph
H
H
H
L A 921
H
Ph
H
H
Ph
H
H
L A 922
H
H
Me
Me
H
H
H
L A 923
H
H
CD 3
Me
H
H
H
L A 924
H
H
i Pr
Me
H
H
H
L A 925
H
H
Ph
Me
H
H
H
L A 926
H
H
Me
CD 3
H
H
H
L A 927
H
H
CD 3
CD 3
H
H
H
L A 928 L A 929 L A 930 L A 931 L A 932 L A 933
H H H H H H
H H H H H H
i Pr Ph Me CD 3 i Pr Ph
CD 3 CD 3 i Pr i Pr i Pr i Pr
H H H H H H
H H H H H H
H H H H H H
L A 934
H
H
Me
Ph
H
H
H
L A 935
H
H
CD 3
Ph
H
H
H
L A 936
H
H
i Pr
Ph
H
H
H
L A 937
H
H
Ph
Ph
H
H
H
L A 938
H
H
Me
H
Me
H
H
L A 939
H
H
CD 3
H
Me
H
H
L A 940
H
H
i Pr
H
Me
H
H
L A 941
H
H
Ph
H
Me
H
H
L A 942
H
H
Me
H
CD 3
H
H
L A 943
H
H
CD 3
H
CD 3
H
H
L A 944
H
H
i Pr
H
CD 3
H
H
L A 945
H
H
Ph
H
CD 3
H
H
L A 946
H
H
Me
H
i Pr
H
H
L A 947
H
H
CD 3
H
i Pr
H
H
L A 948
H
H
i Pr
H
i Pr
H
H
L A 949
H
H
Ph
H
i Pr
H
H
L A 950
H
H
Me
H
Ph
H
H
L A 951
H
H
CD 3
H
Ph
H
H
L A 952
H
H
i Pr
H
Ph
H
H
L A 953
H
H
Ph
H
Ph
H
H
L A 954
Me
Me
H
Me
H
H
H
L A 955
H
Me
Me
Me
H
H
H
L A 956
CD 3
Me
H
Me
H
H
H
L A 957
H
Me
CD 3
Me
H
H
H
L A 958
i Pr
Me
H
Me
H
H
H
L A 959
H
Me
i Pr
Me
H
H
H
L A 960
Ph
Me
H
Me
H
H
H
L A 961
H
Me
Ph
Me
H
H
H
L A 962
Me
CD 3
H
CD 3
H
H
H
L A 963
H
CD 3
Me
CD 3
H
H
H
L A 964
CD 3
CD 3
H
CD 3
H
H
H
L A 965
H
CD 3
CD 3
CD 3
H
H
H
L A 966
i Pr
CD 3
H
CD 3
H
H
H
L A 967
H
CD 3
i Pr
CD 3
H
H
H
L A 968
Ph
CD 3
H
CD 3
H
H
H
L A 969
H
CD 3
Ph
CD 3
H
H
H
L A 970
Me
i Pr
H
i Pr
H
H
H
L A 971
H
i Pr
Me
i Pr
H
H
H
L A 972
CD 3
i Pr
H
i Pr
H
H
H
L A 973
H
i Pr
CD 3
i Pr
H
H
H
L A 974
i Pr
i Pr
H
i Pr
H
H
H
L A 975
H
i Pr
i Pr
i Pr
H
H
H
L A 976
Ph
i Pr
H
i Pr
H
H
H
L A 977
H
i Pr
Ph
i Pr
H
H
H
L A 978
Me
Ph
H
Ph
H
H
H
L A 979
H
Ph
Me
Ph
H
H
H
L A 980
CD 3
Ph
H
Ph
H
H
H
L A 981
H
Ph
CD 3
Ph
H
H
H
L A 982
i Pr
Ph
H
Ph
H
H
H
L A 983 L A 984 L A 985
H Ph H
Ph Ph Ph
i Pr H Ph
Ph Ph Ph
H H H
H H H
H H H
L A 986 L A 987 L A 988 L A 989 L A 990
H Me H H H
H H Me H H
H H H Me H
H H H H Me
H H H H H
H H H H H
H H H H H
L A 991
H
H
H
H
Me
H
H
L A 992
CD 3
H
H
H
H
H
H
L A 993
H
CD 3
H
H
H
H
H
L A 994
H
H
CD 3
H
H
H
H
L A 995
H
H
H
CD 3
H
H
H
L A 996
H
H
H
H
CD 3
H
H
L A 997
i Pr
H
H
H
H
H
H
L A 998
H
i Pr
H
H
H
H
H
L A 999
H
H
i Pr
H
H
H
H
L A 1000
H
H
H
i Pr
H
H
H
L A 1001
H
H
H
H
i Pr
H
H
L A 1002
Ph
H
H
H
H
H
H
L A 1003
H
Ph
H
H
H
H
H
L A 1004
H
H
Ph
H
H
H
H
L A 1005
H
H
H
Ph
H
H
H
L A 1006
H
H
H
H
Ph
H
H
L A 1007
Me
Me
H
H
H
H
H
L A 1008
Me
H
Me
H
H
H
H
L A 1009
Me
H
H
Me
H
H
H
L A 1010
Me
H
H
H
Me
H
H
L A 1011
Me
CD 3
H
H
H
H
H
L A 1012
Me
H
CD 3
H
H
H
H
L A 1013
Me
H
H
CD 3
H
H
H
L A 1014
Me
H
H
H
CD 3
H
H
L A 1015
Me
i Pr
H
H
H
H
H
L A 1016
Me
H
i Pr
H
H
H
H
L A 1017
Me
H
H
i Pr
H
H
H
L A 1018
Me
H
H
H
i Pr
H
H
L A 1019
Me
Ph
H
H
H
H
H
L A 1020
Me
H
Ph
H
H
H
H
L A 1021
Me
H
H
Ph
H
H
H
L A 1022
Me
H
H
H
Ph
H
H
L A 1023
CD 3
Me
H
H
H
H
H
L A 1024
CD 3
H
Me
H
H
H
H
L A 1025
CD 3
H
H
Me
H
H
H
L A 1026
CD 3
H
H
H
Me
H
H
L A 1027
CD 3
CD 3
H
H
H
H
H
L A 1028
CD 3
H
CD 3
H
H
H
H
L A 1029
CD 3
H
H
CD 3
H
H
H
L A 1030
CD 3
H
H
H
CD 3
H
H
L A 1031
CD 3
i Pr
H
H
H
H
H
L A 1032
CD 3
H
i Pr
H
H
H
H
L A 1033
CD 3
H
H
i Pr
H
H
H
L A 1034
CD 3
H
H
H
i Pr
H
H
L A 1035
CD 3
Ph
H
H
H
H
H
L A 1036
CD 3
H
Ph
H
H
H
H
L A 1037
CD 3
H
H
Ph
H
H
H
L A 1038 L A 1039 L A 1040 L A 1041 L A 1042
CD 3 i Pr i Pr i Pr i Pr
H Me H H H
H H Me H H
H H H Me H
Ph H H H Me
H H H H H
H H H H H
L A 1043
i Pr
CD 3
H
H
H
H
H
L A 1044
i Pr
H
CD 3
H
H
H
H
L A 1045
i Pr
H
H
CD 3
H
H
H
L A 1046
i Pr
H
H
H
CD 3
H
H
L A 1047
i Pr
i Pr
H
H
H
H
H
L A 1048
i Pr
H
i Pr
H
H
H
H
L A 1049
i Pr
H
H
i Pr
H
H
H
L A 1050
i Pr
H
H
H
i Pr
H
H
L A 1051
i Pr
Ph
H
H
H
H
H
L A 1052
i Pr
H
Ph
H
H
H
H
L A 1053
i Pr
H
H
Ph
H
H
H
L A 1054
i Pr
H
H
H
Ph
H
H
L A 1055
Ph
Me
H
H
H
H
H
L A 1056
Ph
H
Me
H
H
H
H
L A 1057
Ph
H
H
Me
H
H
H
L A 1058
Ph
H
H
H
Me
H
H
L A 1059
Ph
CD 3
H
H
H
H
H
L A 1060
Ph
H
CD 3
H
H
H
H
L A 1061
Ph
H
H
CD 3
H
H
H
L A 1062
Ph
H
H
H
CD 3
H
H
L A 1063
Ph
i Pr
H
H
H
H
H
L A 1064
Ph
H
i Pr
H
H
H
H
L A 1065
Ph
H
H
i Pr
H
H
H
L A 1066
Ph
H
H
H
i Pr
H
H
L A 1067
Ph
Ph
H
H
H
H
H
L A 1068
Ph
H
Ph
H
H
H
H
L A 1069
Ph
H
H
Ph
H
H
H
L A 1070
Ph
H
H
H
Ph
H
H
L A 1071
H
Me
Me
H
H
H
H
L A 1072
H
Me
H
Me
H
H
H
L A 1073
H
Me
H
H
Me
H
H
L A 1074
H
Me
CD 3
H
H
H
H
L A 1075
H
Me
H
CD 3
H
H
H
L A 1076
H
Me
H
H
CD 3
H
H
L A 1077
H
Me
i Pr
H
H
H
H
L A 1078
H
Me
H
i Pr
H
H
H
L A 1079
H
Me
H
H
i Pr
H
H
L A 1080
H
Me
Ph
H
H
H
H
L A 1081
H
Me
H
Ph
H
H
H
L A 1082
H
Me
H
H
Ph
H
H
L A 1083
H
CD 3
Me
H
H
H
H
L A 1084
H
CD 3
H
Me
H
H
H
L A 1085
H
CD 3
H
H
Me
H
H
L A 1086
H
CD 3
CD 3
H
H
H
H
L A 1087
H
CD 3
H
CD 3
H
H
H
L A 1088
H
CD 3
H
H
CD 3
H
H
L A 1089
H
CD 3
i Pr
H
H
H
H
L A 1090
H
CD 3
H
i Pr
H
H
H
L A 1091
H
CD 3
H
H
i Pr
H
H
L A 1092
H
CD 3
Ph
H
H
H
H
L A 1093 L A 1094 L A 1095 L A 1096 L A 1097
H H H H H
CD 3 CD 3 i Pr i Pr i Pr
H H Me H H
Ph H H Me H
H Ph H H Me
H H H H H
H H H H H
L A 1098
H
i Pr
CD 3
H
H
H
H
L A 1099
H
i Pr
H
CD 3
H
H
H
L A 1100
H
i Pr
H
H
CD 3
H
H
L A 1101
H
i Pr
i Pr
H
H
H
H
L A 1102
H
i Pr
H
i Pr
H
H
H
L A 1103
H
i Pr
H
H
i Pr
H
H
L A 1104
H
i Pr
Ph
H
H
H
H
L A 1105
H
i Pr
H
Ph
H
H
H
L A 1106
H
i Pr
H
H
Ph
H
H
L A 1107
H
Ph
Me
H
H
H
H
L A 1108
H
Ph
H
Me
H
H
H
L A 1109
H
Ph
H
H
Me
H
H
L A 1110
H
Ph
CD 3
H
H
H
H
L A 1111
H
Ph
H
CD 3
H
H
H
L A 1112
H
Ph
H
H
CD 3
H
H
L A 1113
H
Ph
i Pr
H
H
H
H
L A 1114
H
Ph
H
i Pr
H
H
H
L A 1115
H
Ph
H
H
i Pr
H
H
L A 1116
H
Ph
Ph
H
H
H
H
L A 1117
H
Ph
H
Ph
H
H
H
L A 1118
H
Ph
H
H
Ph
H
H
L A 1119
H
H
Me
Me
H
H
H
L A 1120
H
H
CD 3
Me
H
H
H
L A 1121
H
H
i Pr
Me
H
H
H
L A 1122
H
H
Ph
Me
H
H
H
L A 1123
H
H
Me
CD 3
H
H
H
L A 1124
H
H
CD 3
CD 3
H
H
H
L A 1125
H
H
i Pr
CD 3
H
H
H
L A 1126
H
H
Ph
CD 3
H
H
H
L A 1127
H
H
Me
i Pr
H
H
H
L A 1128
H
H
CD 3
i Pr
H
H
H
L A 1129
H
H
i Pr
i Pr
H
H
H
L A 1130
H
H
Ph
i Pr
H
H
H
L A 1131
H
H
Me
Ph
H
H
H
L A 1132
H
H
CD 3
Ph
H
H
H
L A 1133
H
H
i Pr
Ph
H
H
H
L A 1134
H
H
Ph
Ph
H
H
H
L A 1135
H
H
Me
H
Me
H
H
L A 1136
H
H
CD 3
H
Me
H
H
L A 1137
H
H
i Pr
H
Me
H
H
L A 1138
H
H
Ph
H
Me
H
H
L A 1139
H
H
Me
H
CD 3
H
H
L A 1140
H
H
CD 3
H
CD 3
H
H
L A 1141
H
H
i Pr
H
CD 3
H
H
L A 1142
H
H
Ph
H
CD 3
H
H
L A 1143
H
H
Me
H
i Pr
H
H
L A 1144
H
H
CD 3
H
i Pr
H
H
L A 1145
H
H
i Pr
H
i Pr
H
H
L A 1146
H
H
Ph
H
i Pr
H
H
L A 1147
H
H
Me
H
Ph
H
H
L A 1148 L A 1149 L A 1150 L A 1151 L A 1152
H H H Me H
H H H Me Me
CD 3 i Pr Ph H Me
H H H Me Me
Ph Ph Ph H H
H H H H H
H H H H H
L A 1153
CD 3
Me
H
Me
H
H
H
L A 1154
H
Me
CD 3
Me
H
H
H
L A 1155
i Pr
Me
H
Me
H
H
H
L A 1156
H
Me
i Pr
Me
H
H
H
L A 1157
Ph
Me
H
Me
H
H
H
L A 1158
H
Me
Ph
Me
H
H
H
L A 1159
Me
CD 3
H
CD 3
H
H
H
L A 1160
H
CD 3
Me
CD 3
H
H
H
L A 1161
CD 3
CD 3
H
CD 3
H
H
H
L A 1162
H
CD 3
CD 3
CD 3
H
H
H
L A 1163
i Pr
CD 3
H
CD 3
H
H
H
L A 1164
H
CD 3
i Pr
CD 3
H
H
H
L A 1165
Ph
CD 3
H
CD 3
H
H
H
L A 1166
H
CD 3
Ph
CD 3
H
H
H
L A 1167
Me
i Pr
H
i Pr
H
H
H
L A 1168
H
i Pr
Me
i Pr
H
H
H
L A 1169
CD 3
i Pr
H
i Pr
H
H
H
L A 1170
H
i Pr
CD 3
i Pr
H
H
H
L A 1171
i Pr
i Pr
H
i Pr
H
H
H
L A 1172
H
i Pr
i Pr
i Pr
H
H
H
L A 1173
Ph
i Pr
H
i Pr
H
H
H
L A 1174
H
i Pr
Ph
i Pr
H
H
H
L A 1175
Me
Ph
H
Ph
H
H
H
L A 1176
H
Ph
Me
Ph
H
H
H
L A 1177
CD 3
Ph
H
Ph
H
H
H
L A 1178
H
Ph
CD 3
Ph
H
H
H
L A 1179
i Pr
Ph
H
Ph
H
H
H
L A 1180
H
Ph
i Pr
Ph
H
H
H
L A 1181
Ph
Ph
H
Ph
H
H
H
L A 1182
H
Ph
Ph
Ph
H
H
H
L A 1183 L A 1184 L A 1185 L A 1186 L A 1187
H Me H H H
H H Me H H
H H H Me H
H H H H Me
H H H H H
H H H H H
H H H H H
L A 1188
H
H
H
H
Me
H
H
L A 1189
CD 3
H
H
H
H
H
H
L A 1190
H
CD 3
H
H
H
H
H
L A 1191
H
H
CD 3
H
H
H
H
L A 1192
H
H
H
CD 3
H
H
H
L A 1193
H
H
H
H
CD 3
H
H
L A 1194
i Pr
H
H
H
H
H
H
L A 1195
H
i Pr
H
H
H
H
H
L A 1196
H
H
i Pr
H
H
H
H
L A 1197
H
H
H
i Pr
H
H
H
L A 1198
H
H
H
H
i Pr
H
H
L A 1199
Ph
H
H
H
H
H
H
L A 1200
H
Ph
H
H
H
H
H
L A 1201
H
H
Ph
H
H
H
H
L A 1202
H
H
H
Ph
H
H
H
L A 1203 L A 1204 L A 1205 L A 1206 L A 1207
H Me Me Me Me
H Me H H H
H H Me H H
H H H Me H
Ph H H H Me
H H H H H
H H H H H
L A 1208
Me
CD 3
H
H
H
H
H
L A 1209
Me
H
CD 3
H
H
H
H
L A 1210
Me
H
H
CD 3
H
H
H
L A 1211
Me
H
H
H
CD 3
H
H
L A 1212
Me
i Pr
H
H
H
H
H
L A 1213
Me
H
i Pr
H
H
H
H
L A 1214
Me
H
H
i Pr
H
H
H
L A 1215
Me
H
H
H
i Pr
H
H
L A 1216
Me
Ph
H
H
H
H
H
L A 1217
Me
H
Ph
H
H
H
H
L A 1218
Me
H
H
Ph
H
H
H
L A 1219
Me
H
H
H
Ph
H
H
L A 1220
CD 3
Me
H
H
H
H
H
L A 1221
CD 3
H
Me
H
H
H
H
L A 1222
CD 3
H
H
Me
H
H
H
L A 1223
CD 3
H
H
H
Me
H
H
L A 1224
CD 3
CD 3
H
H
H
H
H
L A 1225
CD 3
H
CD 3
H
H
H
H
L A 1226
CD 3
H
H
CD 3
H
H
H
L A 1227
CD 3
H
H
H
CD 3
H
H
L A 1228
CD 3
i Pr
H
H
H
H
H
L A 1229
CD 3
H
i Pr
H
H
H
H
L A 1230
CD 3
H
H
i Pr
H
H
H
L A 1231
CD 3
H
H
H
i Pr
H
H
L A 1232
CD 3
Ph
H
H
H
H
H
L A 1233
CD 3
H
Ph
H
H
H
H
L A 1234
CD 3
H
H
Ph
H
H
H
L A 1235
CD 3
H
H
H
Ph
H
H
L A 1236
i Pr
Me
H
H
H
H
H
L A 1237
i Pr
H
Me
H
H
H
H
L A 1238
i Pr
H
H
Me
H
H
H
L A 1239
i Pr
H
H
H
Me
H
H
L A 1240
i Pr
CD 3
H
H
H
H
H
L A 1241
i Pr
H
CD 3
H
H
H
H
L A 1242
i Pr
H
H
CD 3
H
H
H
L A 1243
i Pr
H
H
H
CD 3
H
H
L A 1244
i Pr
i Pr
H
H
H
H
H
L A 1245
i Pr
H
i Pr
H
H
H
H
L A 1246
i Pr
H
H
i Pr
H
H
H
L A 1247
i Pr
H
H
H
i Pr
H
H
L A 1248
i Pr
Ph
H
H
H
H
H
L A 1249
i Pr
H
Ph
H
H
H
H
L A 1250
i Pr
H
H
Ph
H
H
H
L A 1251
i Pr
H
H
H
Ph
H
H
L A 1252
Ph
Me
H
H
H
H
H
L A 1253
Ph
H
Me
H
H
H
H
L A 1254
Ph
H
H
Me
H
H
H
L A 1255
Ph
H
H
H
Me
H
H
L A 1256
Ph
CD 3
H
H
H
H
H
L A 1257
Ph
H
CD 3
H
H
H
H
L A 1258 L A 1259 L A 1260 L A 1261 L A 1262
Ph Ph Ph Ph Ph
H H i Pr H H
H H H i Pr H
CD 3 H H H i Pr
H CD 3 H H H
H H H H H
H H H H H
L A 1263
Ph
H
H
H
i Pr
H
H
L A 1264
Ph
Ph
H
H
H
H
H
L A 1265
Ph
H
Ph
H
H
H
H
L A 1266
Ph
H
H
Ph
H
H
H
L A 1267
Ph
H
H
H
Ph
H
H
L A 1268
H
Me
Me
H
H
H
H
L A 1269
H
Me
H
Me
H
H
H
L A 1270
H
Me
H
H
Me
H
H
L A 1271
H
Me
CD 3
H
H
H
H
L A 1272
H
Me
H
CD 3
H
H
H
L A 1273
H
Me
H
H
CD 3
H
H
L A 1274
H
Me
i Pr
H
H
H
H
L A 1275
H
Me
H
i Pr
H
H
H
L A 1276
H
Me
H
H
i Pr
H
H
L A 1277
H
Me
Ph
H
H
H
H
L A 1278
H
Me
H
Ph
H
H
H
L A 1279
H
Me
H
H
Ph
H
H
L A 1280
H
CD 3
Me
H
H
H
H
L A 1281
H
CD 3
H
Me
H
H
H
L A 1282
H
CD 3
H
H
Me
H
H
L A 1283
H
CD 3
CD 3
H
H
H
H
L A 1284
H
CD 3
H
CD 3
H
H
H
L A 1285
H
CD 3
H
H
CD 3
H
H
L A 1286
H
CD 3
i Pr
H
H
H
H
L A 1287
H
CD 3
H
i Pr
H
H
H
L A 1288
H
CD 3
H
H
i Pr
H
H
L A 1289
H
CD 3
Ph
H
H
H
H
L A 1290
H
CD 3
H
Ph
H
H
H
L A 1291
H
CD 3
H
H
Ph
H
H
L A 1292
H
i Pr
Me
H
H
H
H
L A 1293
H
i Pr
H
Me
H
H
H
L A 1294
H
i Pr
H
H
Me
H
H
L A 1295
H
i Pr
CD 3
H
H
H
H
L A 1296
H
i Pr
H
CD 3
H
H
H
L A 1297
H
i Pr
H
H
CD 3
H
H
L A 1298
H
i Pr
i Pr
H
H
H
H
L A 1299
H
i Pr
H
i Pr
H
H
H
L A 1300
H
i Pr
H
H
i Pr
H
H
L A 1301
H
i Pr
Ph
H
H
H
H
L A 1302
H
i Pr
H
Ph
H
H
H
L A 1303
H
i Pr
H
H
Ph
H
H
L A 1304
H
Ph
Me
H
H
H
H
L A 1305
H
Ph
H
Me
H
H
H
L A 1306
H
Ph
H
H
Me
H
H
L A 1307
H
Ph
CD 3
H
H
H
H
L A 1308
H
Ph
H
CD 3
H
H
H
L A 1309
H
Ph
H
H
CD 3
H
H
L A 1310
H
Ph
i Pr
H
H
H
H
L A 1311
H
Ph
H
i Pr
H
H
H
L A 1312
H
Ph
H
H
i Pr
H
H
L A 1313 L A 1314 L A 1315 L A 1316 L A 1317
H H H H H
Ph Ph Ph H H
Ph H H Me CD 3
H Ph H Me Me
H H Ph H H
H H H H H
H H H H H
L A 1318
H
H
i Pr
Me
H
H
H
L A 1319
H
H
Ph
Me
H
H
H
L A 1320
H
H
Me
CD 3
H
H
H
L A 1321
H
H
CD 3
CD 3
H
H
H
L A 1322
H
H
i Pr
CD 3
H
H
H
L A 1323
H
H
Ph
CD 3
H
H
H
L A 1324
H
H
Me
i Pr
H
H
H
L A 1325
H
H
CD 3
i Pr
H
H
H
L A 1326
H
H
i Pr
i Pr
H
H
H
L A 1327
H
H
Ph
i Pr
H
H
H
L A 1328
H
H
Me
Ph
H
H
H
L A 1329
H
H
CD 3
Ph
H
H
H
L A 1330
H
H
i Pr
Ph
H
H
H
L A 1331
H
H
Ph
Ph
H
H
H
L A 1332
H
H
Me
H
Me
H
H
L A 1333
H
H
CD 3
H
Me
H
H
L A 1334
H
H
i Pr
H
Me
H
H
L A 1335
H
H
Ph
H
Me
H
H
L A 1336
H
H
Me
H
CD 3
H
H
L A 1337
H
H
CD 3
H
CD 3
H
H
L A 1338
H
H
i Pr
H
CD 3
H
H
L A 1339
H
H
Ph
H
CD 3
H
H
L A 1340
H
H
Me
H
i Pr
H
H
L A 1341
H
H
CD 3
H
i Pr
H
H
L A 1342
H
H
i Pr
H
i Pr
H
H
L A 1343
H
H
Ph
H
i Pr
H
H
L A 1344
H
H
Me
H
Ph
H
H
L A 1345
H
H
CD 3
H
Ph
H
H
L A 1346
H
H
i Pr
H
Ph
H
H
L A 1347
H
H
Ph
H
Ph
H
H
L A 1348
Me
Me
H
Me
H
H
H
L A 1349
H
Me
Me
Me
H
H
H
L A 1350
CD 3
Me
H
Me
H
H
H
L A 1351
H
Me
CD 3
Me
H
H
H
L A 1352
i Pr
Me
H
Me
H
H
H
L A 1353
H
Me
i Pr
Me
H
H
H
L A 1354
Ph
Me
H
Me
H
H
H
L A 1355
H
Me
Ph
Me
H
H
H
L A 1356
Me
CD 3
H
CD 3
H
H
H
L A 1357
H
CD 3
Me
CD 3
H
H
H
L A 1358
CD 3
CD 3
H
CD 3
H
H
H
L A 1359
H
CD 3
CD 3
CD 3
H
H
H
L A 1360
i Pr
CD 3
H
CD 3
H
H
H
L A 1361
H
CD 3
i Pr
CD 3
H
H
H
L A 1362
Ph
CD 3
H
CD 3
H
H
H
L A 1363
H
CD 3
Ph
CD 3
H
H
H
L A 1364
Me
i Pr
H
i Pr
H
H
H
L A 1365
H
i Pr
Me
i Pr
H
H
H
L A 1366
CD 3
i Pr
H
i Pr
H
H
H
L A 1367
H
i Pr
CD 3
i Pr
H
H
H
L A 1368 L A 1369 L A 1370 L A 1371 L A 1372
i Pr H Ph H Me
i Pr i Pr i Pr i Pr Ph
H i Pr H Ph H
i Pr i Pr i Pr i Pr Ph
H H H H H
H H H H H
H H H H H
L A 1373
H
Ph
Me
Ph
H
H
H
L A 1374
CD 3
Ph
H
Ph
H
H
H
L A 1375
H
Ph
CD 3
Ph
H
H
H
L A 1376
i Pr
Ph
H
Ph
H
H
H
L A 1377
H
Ph
i Pr
Ph
H
H
H
L A 1378
Ph
Ph
H
Ph
H
H
H
L A 1379
H
Ph
Ph
Ph
H
H
H
L A 1380 L A 1381 L A 1382 L A 1383 L A 1384 L A 1385 L A 1386
H Me H H H H CD 3
H H Me H H H H
H H H Me H H H
H H H H Me H H
H H H H H Me H
H H H H H H H
H H H H H H H
L A 1387
H
CD 3
H
H
H
H
H
L A 1388
H
H
CD 3
H
H
H
H
L A 1389
H
H
H
CD 3
H
H
H
L A 1390
H
H
H
H
CD 3
H
H
L A 1391
i Pr
H
H
H
H
H
H
L A 1392
H
i Pr
H
H
H
H
H
L A 1393
H
H
i Pr
H
H
H
H
L A 1394
H
H
H
i Pr
H
H
H
L A 1395
H
H
H
H
i Pr
H
H
L A 1396
Ph
H
H
H
H
H
H
L A 1397
H
Ph
H
H
H
H
H
L A 1398
H
H
Ph
H
H
H
H
L A 1399
H
H
H
Ph
H
H
H
L A 1400
H
H
H
H
Ph
H
H
L A 1401
Me
Me
H
H
H
H
H
L A 1402
Me
H
Me
H
H
H
H
L A 1403
Me
H
H
Me
H
H
H
L A 1404
Me
H
H
H
Me
H
H
L A 1405
Me
CD 3
H
H
H
H
H
L A 1406
Me
H
CD 3
H
H
H
H
L A 1407
Me
H
H
CD 3
H
H
H
L A 1408
Me
H
H
H
CD 3
H
H
L A 1409
Me
i Pr
H
H
H
H
H
L A 1410
Me
H
i Pr
H
H
H
H
L A 1411
Me
H
H
i Pr
H
H
H
L A 1412
Me
H
H
H
i Pr
H
H
L A 1413
Me
Ph
H
H
H
H
H
L A 1414
Me
H
Ph
H
H
H
H
L A 1415
Me
H
H
Ph
H
H
H
L A 1416
Me
H
H
H
Ph
H
H
L A 1417
CD 3
Me
H
H
H
H
H
L A 1418
CD 3
H
Me
H
H
H
H
L A 1419
CD 3
H
H
Me
H
H
H
L A 1420
CD 3
H
H
H
Me
H
H
L A 1421
CD 3
CD 3
H
H
H
H
H
L A 1422
CD 3
H
CD 3
H
H
H
H
L A 1423 L A 1424 L A 1425 L A 1426 L A 1427 L A 1428 L A 1429
CD 3 CD 3 CD 3 CD 3 CD 3 CD 3 CD 3
H H i Pr H H H Ph
H H H i Pr H H H
CD 3 H H H i Pr H H
H CD 3 H H H i Pr H
H H H H H H H
H H H H H H H
L A 1430
CD 3
H
Ph
H
H
H
H
L A 1431
CD 3
H
H
Ph
H
H
H
L A 1432
CD 3
H
H
H
Ph
H
H
L A 1433
i Pr
Me
H
H
H
H
H
L A 1434
i Pr
H
Me
H
H
H
H
L A 1435
i Pr
H
H
Me
H
H
H
L A 1436
i Pr
H
H
H
Me
H
H
L A 1437
i Pr
CD 3
H
H
H
H
H
L A 1438
i Pr
H
CD 3
H
H
H
H
L A 1439
i Pr
H
H
CD 3
H
H
H
L A 1440
i Pr
H
H
H
CD 3
H
H
L A 1441
i Pr
i Pr
H
H
H
H
H
L A 1442
i Pr
H
i Pr
H
H
H
H
L A 1443
i Pr
H
H
i Pr
H
H
H
L A 1444
i Pr
H
H
H
i Pr
H
H
L A 1445
i Pr
Ph
H
H
H
H
H
L A 1446
i Pr
H
Ph
H
H
H
H
L A 1447
i Pr
H
H
Ph
H
H
H
L A 1448
i Pr
H
H
H
Ph
H
H
L A 1449
Ph
Me
H
H
H
H
H
L A 1450
Ph
H
Me
H
H
H
H
L A 1451
Ph
H
H
Me
H
H
H
L A 1452
Ph
H
H
H
Me
H
H
L A 1453
Ph
CD 3
H
H
H
H
H
L A 1454
Ph
H
CD 3
H
H
H
H
L A 1455
Ph
H
H
CD 3
H
H
H
L A 1456
Ph
H
H
H
CD 3
H
H
L A 1457
Ph
i Pr
H
H
H
H
H
L A 1458
Ph
H
i Pr
H
H
H
H
L A 1459
Ph
H
H
i Pr
H
H
H
L A 1460
Ph
H
H
H
i Pr
H
H
L A 1461
Ph
Ph
H
H
H
H
H
L A 1462
Ph
H
Ph
H
H
H
H
L A 1463
Ph
H
H
Ph
H
H
H
L A 1464
Ph
H
H
H
Ph
H
H
L A 1465
H
Me
Me
H
H
H
H
L A 1466
H
Me
H
Me
H
H
H
L A 1467
H
Me
H
H
Me
H
H
L A 1468
H
Me
CD 3
H
H
H
H
L A 1469
H
Me
H
CD 3
H
H
H
L A 1470
H
Me
H
H
CD 3
H
H
L A 1471
H
Me
i Pr
H
H
H
H
L A 1472
H
Me
H
i Pr
H
H
H
L A 1473
H
Me
H
H
i Pr
H
H
L A 1474
H
Me
Ph
H
H
H
H
L A 1475
H
Me
H
Ph
H
H
H
L A 1476
H
Me
H
H
Ph
H
H
L A 1477
H
CD 3
Me
H
H
H
H
L A 1478 L A 1479 L A 1480 L A 1481 L A 1482 L A 1483 L A 1484
H H H H H H H
CD 3 CD 3 CD 3 CD 3 CD 3 CD 3 CD 3
H H CD 3 H H i Pr H
Me H H CD 3 H H i Pr
H Me H H CD 3 H H
H H H H H H H
H H H H H H H
L A 1485
H
CD 3
H
H
i Pr
H
H
L A 1486
H
CD 3
Ph
H
H
H
H
L A 1487
H
CD 3
H
Ph
H
H
H
L A 1488
H
CD 3
H
H
Ph
H
H
L A 1489
H
i Pr
Me
H
H
H
H
L A 1490
H
i Pr
H
Me
H
H
H
L A 1491
H
i Pr
H
H
Me
H
H
L A 1492
H
i Pr
CD 3
H
H
H
H
L A 1493
H
i Pr
H
CD 3
H
H
H
L A 1494
H
i Pr
H
H
CD 3
H
H
L A 1495
H
i Pr
i Pr
H
H
H
H
L A 1496
H
i Pr
H
i Pr
H
H
H
L A 1497
H
i Pr
H
H
i Pr
H
H
L A 1498
H
i Pr
Ph
H
H
H
H
L A 1499
H
i Pr
H
Ph
H
H
H
L A 1500
H
i Pr
H
H
Ph
H
H
L A 1501
H
Ph
Me
H
H
H
H
L A 1502
H
Ph
H
Me
H
H
H
L A 1503
H
Ph
H
H
Me
H
H
L A 1504
H
Ph
CD 3
H
H
H
H
L A 1505
H
Ph
H
CD 3
H
H
H
L A 1506
H
Ph
H
H
CD 3
H
H
L A 1507
H
Ph
i Pr
H
H
H
H
L A 1508
H
Ph
H
i Pr
H
H
H
L A 1509
H
Ph
H
H
i Pr
H
H
L A 1510
H
Ph
Ph
H
H
H
H
L A 1511
H
Ph
H
Ph
H
H
H
L A 1512
H
Ph
H
H
Ph
H
H
L A 1513
H
H
Me
Me
H
H
H
L A 1514
H
H
CD 3
Me
H
H
H
L A 1515
H
H
i Pr
Me
H
H
H
L A 1516
H
H
Ph
Me
H
H
H
L A 1517
H
H
Me
CD 3
H
H
H
L A 1518
H
H
CD 3
CD 3
H
H
H
L A 1519
H
H
i Pr
CD 3
H
H
H
L A 1520
H
H
Ph
CD 3
H
H
H
L A 1521
H
H
Me
i Pr
H
H
H
L A 1522
H
H
CD 3
i Pr
H
H
H
L A 1523
H
H
i Pr
i Pr
H
H
H
L A 1524
H
H
Ph
i Pr
H
H
H
L A 1525
H
H
Me
Ph
H
H
H
L A 1526
H
H
CD 3
Ph
H
H
H
L A 1527
H
H
i Pr
Ph
H
H
H
L A 1528
H
H
Ph
Ph
H
H
H
L A 1529
H
H
Me
H
Me
H
H
L A 1530
H
H
CD 3
H
Me
H
H
L A 1531
H
H
i Pr
H
Me
H
H
L A 1532
H
H
Ph
H
Me
H
H
L A 1533 L A 1534 L A 1535 L A 1536 L A 1537 L A 1538 L A 1539
H H H H H H H
H H H H H H H
Me CD 3 i Pr Ph Me CD 3 i Pr
H H H H H H H
CD 3 CD 3 CD 3 CD 3 i Pr i Pr i Pr
H H H H H H H
H H H H H H H
L A 1540
H
H
Ph
H
i Pr
H
H
L A 1541
H
H
Me
H
Ph
H
H
L A 1542
H
H
CD 3
H
Ph
H
H
L A 1543
H
H
i Pr
H
Ph
H
H
L A 1544
H
H
Ph
H
Ph
H
H
L A 1545
Me
Me
H
Me
H
H
H
L A 1546
H
Me
Me
Me
H
H
H
L A 1547
CD 3
Me
H
Me
H
H
H
L A 1548
H
Me
CD 3
Me
H
H
H
L A 1549
i Pr
Me
H
Me
H
H
H
L A 1550
H
Me
i Pr
Me
H
H
H
L A 1551
Ph
Me
H
Me
H
H
H
L A 1552
H
Me
Ph
Me
H
H
H
L A 1553
Me
CD 3
H
CD 3
H
H
H
L A 1554
H
CD 3
Me
CD 3
H
H
H
L A 1555
CD 3
CD 3
H
CD 3
H
H
H
L A 1556
H
CD 3
CD 3
CD 3
H
H
H
L A 1557
i Pr
CD 3
H
CD 3
H
H
H
L A 1558
H
CD 3
i Pr
CD 3
H
H
H
L A 1559
Ph
CD 3
H
CD 3
H
H
H
L A 1560
H
CD 3
Ph
CD 3
H
H
H
L A 1561
Me
i Pr
H
i Pr
H
H
H
L A 1562
H
i Pr
Me
i Pr
H
H
H
L A 1563
CD 3
i Pr
H
i Pr
H
H
H
L A 1564
H
i Pr
CD 3
i Pr
H
H
H
L A 1565
i Pr
i Pr
H
i Pr
H
H
H
L A 1566
H
i Pr
i Pr
i Pr
H
H
H
L A 1567
Ph
i Pr
H
i Pr
H
H
H
L A 1568
H
i Pr
Ph
i Pr
H
H
H
L A 1569
Me
Ph
H
Ph
H
H
H
L A 1570
H
Ph
Me
Ph
H
H
H
L A 1571
CD 3
Ph
H
Ph
H
H
H
L A 1572
H
Ph
CD 3
Ph
H
H
H
L A 1573
i Pr
Ph
H
Ph
H
H
H
L A 1574
H
Ph
i Pr
Ph
H
H
H
L A 1575
Ph
Ph
H
Ph
H
H
H
L A 1576
H
Ph
Ph
Ph
H
H
H
L A 1577 L A 1578 L A 1579 L A 1580 L A 1581 L A 1582 L A 1583
H Me H H H H CD 3
H H Me H H H H
H H H Me H H H
H H H H Me H H
H H H H H Me H
H H H H H H H
H H H H H H H
L A 1584
H
CD 3
H
H
H
H
H
L A 1585
H
H
CD 3
H
H
H
H
L A 1586
H
H
H
CD 3
H
H
H
L A 1587
H
H
H
H
CD 3
H
H
L A 1588 L A 1589 L A 1590 L A 1591 L A 1592 L A 1593 L A 1594
i Pr H H H H Ph H
H i Pr H H H H Ph
H H i Pr H H H H
H H H i Pr H H H
H H H H i Pr H H
H H H H H H H
H H H H H H H
L A 1595
H
H
Ph
H
H
H
H
L A 1596
H
H
H
Ph
H
H
H
L A 1597
H
H
H
H
Ph
H
H
L A 1598
Me
Me
H
H
H
H
H
L A 1599
Me
H
Me
H
H
H
H
L A 1600
Me
H
H
Me
H
H
H
L A 1601
Me
H
H
H
Me
H
H
L A 1602
Me
CD 3
H
H
H
H
H
L A 1603
Me
H
CD 3
H
H
H
H
L A 1604
Me
H
H
CD 3
H
H
H
L A 1605
Me
H
H
H
CD 3
H
H
L A 1606
Me
i Pr
H
H
H
H
H
L A 1607
Me
H
i Pr
H
H
H
H
L A 1608
Me
H
H
i Pr
H
H
H
L A 1609
Me
H
H
H
i Pr
H
H
L A 1610
Me
Ph
H
H
H
H
H
L A 1611
Me
H
Ph
H
H
H
H
L A 1612
Me
H
H
Ph
H
H
H
L A 1613
Me
H
H
H
Ph
H
H
L A 1614
CD 3
Me
H
H
H
H
H
L A 1615
CD 3
H
Me
H
H
H
H
L A 1616
CD 3
H
H
Me
H
H
H
L A 1617
CD 3
H
H
H
Me
H
H
L A 1618
CD 3
CD 3
H
H
H
H
H
L A 1619
CD 3
H
CD 3
H
H
H
H
L A 1620
CD 3
H
H
CD 3
H
H
H
L A 1621
CD 3
H
H
H
CD 3
H
H
L A 1622
CD 3
i Pr
H
H
H
H
H
L A 1623
CD 3
H
i Pr
H
H
H
H
L A 1624
CD 3
H
H
i Pr
H
H
H
L A 1625
CD 3
H
H
H
i Pr
H
H
L A 1626
CD 3
Ph
H
H
H
H
H
L A 1627
CD 3
H
Ph
H
H
H
H
L A 1628
CD 3
H
H
Ph
H
H
H
L A 1629
CD 3
H
H
H
Ph
H
H
L A 1630
i Pr
Me
H
H
H
H
H
L A 1631
i Pr
H
Me
H
H
H
H
L A 1632
i Pr
H
H
Me
H
H
H
L A 1633
i Pr
H
H
H
Me
H
H
L A 1634
i Pr
CD 3
H
H
H
H
H
L A 1635
i Pr
H
CD 3
H
H
H
H
L A 1636
i Pr
H
H
CD 3
H
H
H
L A 1637
i Pr
H
H
H
CD 3
H
H
L A 1638
i Pr
i Pr
H
H
H
H
H
L A 1639
i Pr
H
i Pr
H
H
H
H
L A 1640
i Pr
H
H
i Pr
H
H
H
L A 1641
i Pr
H
H
H
i Pr
H
H
L A 1642
i Pr
Ph
H
H
H
H
H
L A 1643 L A 1644 L A 1645 L A 1646 L A 1647 L A 1648 L A 1649
i Pr i Pr i Pr Ph Ph Ph Ph
H H H Me H H H
Ph H H H Me H H
H Ph H H H Me H
H H Ph H H H Me
H H H H H H H
H H H H H H H
L A 1650
Ph
CD 3
H
H
H
H
H
L A 1651
Ph
H
CD 3
H
H
H
H
L A 1652
Ph
H
H
CD 3
H
H
H
L A 1653
Ph
H
H
H
CD 3
H
H
L A 1654
Ph
i Pr
H
H
H
H
H
L A 1655
Ph
H
i Pr
H
H
H
H
L A 1656
Ph
H
H
i Pr
H
H
H
L A 1657
Ph
H
H
H
i Pr
H
H
L A 1658
Ph
Ph
H
H
H
H
H
L A 1659
Ph
H
Ph
H
H
H
H
L A 1660
Ph
H
H
Ph
H
H
H
L A 1661
Ph
H
H
H
Ph
H
H
L A 1662
H
Me
Me
H
H
H
H
L A 1663
H
Me
H
Me
H
H
H
L A 1664
H
Me
H
H
Me
H
H
L A 1665
H
Me
CD 3
H
H
H
H
L A 1666
H
Me
H
CD 3
H
H
H
L A 1667
H
Me
H
H
CD 3
H
H
L A 1668
H
Me
i Pr
H
H
H
H
L A 1669
H
Me
H
i Pr
H
H
H
L A 1670
H
Me
H
H
i Pr
H
H
L A 1671
H
Me
Ph
H
H
H
H
L A 1672
H
Me
H
Ph
H
H
H
L A 1673
H
Me
H
H
Ph
H
H
L A 1674
H
CD 3
Me
H
H
H
H
L A 1675
H
CD 3
H
Me
H
H
H
L A 1676
H
CD 3
H
H
Me
H
H
L A 1677
H
CD 3
CD 3
H
H
H
H
L A 1678
H
CD 3
H
CD 3
H
H
H
L A 1679
H
CD 3
H
H
CD 3
H
H
L A 1680
H
CD 3
i Pr
H
H
H
H
L A 1681
H
CD 3
H
i Pr
H
H
H
L A 1682
H
CD 3
H
H
i Pr
H
H
L A 1683
H
CD 3
Ph
H
H
H
H
L A 1684
H
CD 3
H
Ph
H
H
H
L A 1685
H
CD 3
H
H
Ph
H
H
L A 1686
H
i Pr
Me
H
H
H
H
L A 1687
H
i Pr
H
Me
H
H
H
L A 1688
H
i Pr
H
H
Me
H
H
L A 1689
H
i Pr
CD 3
H
H
H
H
L A 1690
H
i Pr
H
CD 3
H
H
H
L A 1691
H
i Pr
H
H
CD 3
H
H
L A 1692
H
i Pr
i Pr
H
H
H
H
L A 1693
H
i Pr
H
i Pr
H
H
H
L A 1694
H
i Pr
H
H
i Pr
H
H
L A 1695
H
i Pr
Ph
H
H
H
H
L A 1696
H
i Pr
H
Ph
H
H
H
L A 1697
H
i Pr
H
H
Ph
H
H
L A 1698 L A 1699 L A 1700 L A 1701 L A 1702 L A 1703 L A 1704
H H H H H H H
Ph Ph Ph Ph Ph Ph Ph
Me H H CD 3 H H i Pr
H Me H H CD 3 H H
H H Me H H CD 3 H
H H H H H H H
H H H H H H H
L A 1705
H
Ph
H
i Pr
H
H
H
L A 1706
H
Ph
H
H
i Pr
H
H
L A 1707
H
Ph
Ph
H
H
H
H
L A 1708
H
Ph
H
Ph
H
H
H
L A 1709
H
Ph
H
H
Ph
H
H
L A 1710
H
H
Me
Me
H
H
H
L A 1711
H
H
CD 3
Me
H
H
H
L A 1712
H
H
i Pr
Me
H
H
H
L A 1713
H
H
Ph
Me
H
H
H
L A 1714
H
H
Me
CD 3
H
H
H
L A 1715
H
H
CD 3
CD 3
H
H
H
L A 1716
H
H
i Pr
CD 3
H
H
H
L A 1717
H
H
Ph
CD 3
H
H
H
L A 1718
H
H
Me
i Pr
H
H
H
L A 1719
H
H
CD 3
i Pr
H
H
H
L A 1720
H
H
i Pr
i Pr
H
H
H
L A 1721
H
H
Ph
i Pr
H
H
H
L A 1722
H
H
Me
Ph
H
H
H
L A 1723
H
H
CD 3
Ph
H
H
H
L A 1724
H
H
i Pr
Ph
H
H
H
L A 1725
H
H
Ph
Ph
H
H
H
L A 1726
H
H
Me
H
Me
H
H
L A 1727
H
H
CD 3
H
Me
H
H
L A 1728
H
H
i Pr
H
Me
H
H
L A 1729
H
H
Ph
H
Me
H
H
L A 1730
H
H
Me
H
CD 3
H
H
L A 1731
H
H
CD 3
H
CD 3
H
H
L A 1732
H
H
i Pr
H
CD 3
H
H
L A 1733
H
H
Ph
H
CD 3
H
H
L A 1734
H
H
Me
H
i Pr
H
H
L A 1735
H
H
CD 3
H
i Pr
H
H
L A 1736
H
H
i Pr
H
i Pr
H
H
L A 1737
H
H
Ph
H
i Pr
H
H
L A 1738
H
H
Me
H
Ph
H
H
L A 1739
H
H
CD 3
H
Ph
H
H
L A 1740
H
H
i Pr
H
Ph
H
H
L A 1741
H
H
Ph
H
Ph
H
H
L A 1742
Me
Me
H
Me
H
H
H
L A 1743
H
Me
Me
Me
H
H
H
L A 1744
CD 3
Me
H
Me
H
H
H
L A 1745
H
Me
CD 3
Me
H
H
H
L A 1746
i Pr
Me
H
Me
H
H
H
L A 1747
H
Me
i Pr
Me
H
H
H
L A 1748
Ph
Me
H
Me
H
H
H
L A 1749
H
Me
Ph
Me
H
H
H
L A 1750
Me
CD 3
H
CD 3
H
H
H
L A 1751
H
CD 3
Me
CD 3
H
H
H
L A 1752
CD 3
CD 3
H
CD 3
H
H
H
L A 1753 L A 1754 L A 1755 L A 1756 L A 1757 L A 1758 L A 1759
H i Pr H Ph H Me H
CD 3 CD 3 CD 3 CD 3 CD 3 i Pr i Pr
CD 3 H i Pr H Ph H Me
CD 3 CD 3 CD 3 CD 3 CD 3 i Pr i Pr
H H H H H H H
H H H H H H H
H H H H H H H
L A 1760
CD 3
i Pr
H
i Pr
H
H
H
L A 1761
H
i Pr
CD 3
i Pr
H
H
H
L A 1762
i Pr
i Pr
H
i Pr
H
H
H
L A 1763
H
i Pr
i Pr
i Pr
H
H
H
L A 1764
Ph
i Pr
H
i Pr
H
H
H
L A 1765
H
i Pr
Ph
i Pr
H
H
H
L A 1766
Me
Ph
H
Ph
H
H
H
L A 1767
H
Ph
Me
Ph
H
H
H
L A 1768
CD 3
Ph
H
Ph
H
H
H
L A 1769
H
Ph
CD 3
Ph
H
H
H
L A 1770
i Pr
Ph
H
Ph
H
H
H
L A 1771
H
Ph
i Pr
Ph
H
H
H
L A 1772
Ph
Ph
H
Ph
H
H
H
L A 1773
H
Ph
Ph
Ph
H
H
H
L A 1774 L A 1775 L A 1776 L A 1777 L A 1778 L A 1779
H Me H H H H
H H Me H H H
H H H Me H H
H H H H Me H
H H H H H Me
H H H H H H
H H H H H H
L A 1780
CD 3
H
H
H
H
H
H
L A 1781
H
CD 3
H
H
H
H
H
L A 1782
H
H
CD 3
H
H
H
H
L A 1783
H
H
H
CD 3
H
H
H
L A 1784
H
H
H
H
CD 3
H
H
L A 1785
i Pr
H
H
H
H
H
H
L A 1786
H
i Pr
H
H
H
H
H
L A 1787
H
H
i Pr
H
H
H
H
L A 1788
H
H
H
i Pr
H
H
H
L A 1789
H
H
H
H
i Pr
H
H
L A 1790
Ph
H
H
H
H
H
H
L A 1791
H
Ph
H
H
H
H
H
L A 1792
H
H
Ph
H
H
H
H
L A 1793
H
H
H
Ph
H
H
H
L A 1794
H
H
H
H
Ph
H
H
L A 1795
Me
Me
H
H
H
H
H
L A 1796
Me
H
Me
H
H
H
H
L A 1797
Me
H
H
Me
H
H
H
L A 1798
Me
H
H
H
Me
H
H
L A 1799
Me
CD 3
H
H
H
H
H
L A 1800
Me
H
CD 3
H
H
H
H
L A 1801
Me
H
H
CD 3
H
H
H
L A 1802
Me
H
H
H
CD 3
H
H
L A 1803
Me
i Pr
H
H
H
H
H
L A 1804
Me
H
i Pr
H
H
H
H
L A 1805
Me
H
H
i Pr
H
H
H
L A 1806
Me
H
H
H
i Pr
H
H
L A 1807
Me
Ph
H
H
H
H
H
L A 1808 L A 1809 L A 1810 L A 1811 L A 1812 L A 1813
Me Me Me CD 3 CD 3 CD 3
H H H Me H H
Ph H H H Me H
H Ph H H H Me
H H Ph H H H
H H H H H H
H H H H H H
L A 1814
CD 3
H
H
H
Me
H
H
L A 1815
CD 3
CD 3
H
H
H
H
H
L A 1816
CD 3
H
CD 3
H
H
H
H
L A 1817
CD 3
H
H
CD 3
H
H
H
L A 1818
CD 3
H
H
H
CD 3
H
H
L A 1819
CD 3
i Pr
H
H
H
H
H
L A 1820
CD 3
H
i Pr
H
H
H
H
L A 1821
CD 3
H
H
i Pr
H
H
H
L A 1822
CD 3
H
H
H
i Pr
H
H
L A 1823
CD 3
Ph
H
H
H
H
H
L A 1824
CD 3
H
Ph
H
H
H
H
L A 1825
CD 3
H
H
Ph
H
H
H
L A 1826
CD 3
H
H
H
Ph
H
H
L A 1827
i Pr
Me
H
H
H
H
H
L A 1828
i Pr
H
Me
H
H
H
H
L A 1829
i Pr
H
H
Me
H
H
H
L A 1830
i Pr
H
H
H
Me
H
H
L A 1831
i Pr
CD 3
H
H
H
H
H
L A 1832
i Pr
H
CD 3
H
H
H
H
L A 1833
i Pr
H
H
CD 3
H
H
H
L A 1834
i Pr
H
H
H
CD 3
H
H
L A 1835
i Pr
i Pr
H
H
H
H
H
L A 1836
i Pr
H
i Pr
H
H
H
H
L A 1837
i Pr
H
H
i Pr
H
H
H
L A 1838
i Pr
H
H
H
i Pr
H
H
L A 1839
i Pr
Ph
H
H
H
H
H
L A 1840
i Pr
H
Ph
H
H
H
H
L A 1841
i Pr
H
H
Ph
H
H
H
L A 1842
i Pr
H
H
H
Ph
H
H
L A 1843
Ph
Me
H
H
H
H
H
L A 1844
Ph
H
Me
H
H
H
H
L A 1845
Ph
H
H
Me
H
H
H
L A 1846
Ph
H
H
H
Me
H
H
L A 1847
Ph
CD 3
H
H
H
H
H
L A 1848
Ph
H
CD 3
H
H
H
H
L A 1849
Ph
H
H
CD 3
H
H
H
L A 1850
Ph
H
H
H
CD 3
H
H
L A 1851
Ph
i Pr
H
H
H
H
H
L A 1852
Ph
H
i Pr
H
H
H
H
L A 1853
Ph
H
H
i Pr
H
H
H
L A 1854
Ph
H
H
H
i Pr
H
H
L A 1855
Ph
Ph
H
H
H
H
H
L A 1856
Ph
H
Ph
H
H
H
H
L A 1857
Ph
H
H
Ph
H
H
H
L A 1858
Ph
H
H
H
Ph
H
H
L A 1859
H
Me
Me
H
H
H
H
L A 1860
H
Me
H
Me
H
H
H
L A 1861
H
Me
H
H
Me
H
H
L A 1862
H
Me
CD 3
H
H
H
H
L A 1863 L A 1864 L A 1865 L A 1866 L A 1867 L A 1868
H H H H H H
Me Me Me Me Me Me
H H i Pr H H Ph
CD 3 H H i Pr H H
H CD 3 H H i Pr H
H H H H H H
H H H H H H
L A 1869
H
Me
H
Ph
H
H
H
L A 1870
H
Me
H
H
Ph
H
H
L A 1871
H
CD 3
Me
H
H
H
H
L A 1872
H
CD 3
H
Me
H
H
H
L A 1873
H
CD 3
H
H
Me
H
H
L A 1874
H
CD 3
CD 3
H
H
H
H
L A 1875
H
CD 3
H
CD 3
H
H
H
L A 1876
H
CD 3
H
H
CD 3
H
H
L A 1877
H
CD 3
i Pr
H
H
H
H
L A 1878
H
CD 3
H
i Pr
H
H
H
L A 1879
H
CD 3
H
H
i Pr
H
H
L A 1880
H
CD 3
Ph
H
H
H
H
L A 1881
H
CD 3
H
Ph
H
H
H
L A 1882
H
CD 3
H
H
Ph
H
H
L A 1883
H
i Pr
Me
H
H
H
H
L A 1884
H
i Pr
H
Me
H
H
H
L A 1885
H
i Pr
H
H
Me
H
H
L A 1886
H
i Pr
CD 3
H
H
H
H
L A 1887
H
i Pr
H
CD 3
H
H
H
L A 1888
H
i Pr
H
H
CD 3
H
H
L A 1889
H
i Pr
i Pr
H
H
H
H
L A 1890
H
i Pr
H
i Pr
H
H
H
L A 1891
H
i Pr
H
H
i Pr
H
H
L A 1892
H
i Pr
Ph
H
H
H
H
L A 1893
H
i Pr
H
Ph
H
H
H
L A 1894
H
i Pr
H
H
Ph
H
H
L A 1895
H
Ph
Me
H
H
H
H
L A 1896
H
Ph
H
Me
H
H
H
L A 1897
H
Ph
H
H
Me
H
H
L A 1898
H
Ph
CD 3
H
H
H
H
L A 1899
H
Ph
H
CD 3
H
H
H
L A 1900
H
Ph
H
H
CD 3
H
H
L A 1901
H
Ph
i Pr
H
H
H
H
L A 1902
H
Ph
H
i Pr
H
H
H
L A 1903
H
Ph
H
H
i Pr
H
H
L A 1904
H
Ph
Ph
H
H
H
H
L A 1905
H
Ph
H
Ph
H
H
H
L A 1906
H
Ph
H
H
Ph
H
H
L A 1907
H
H
Me
Me
H
H
H
L A 1908
H
H
CD 3
Me
H
H
H
L A 1909
H
H
i Pr
Me
H
H
H
L A 1910
H
H
Ph
Me
H
H
H
L A 1911
H
H
Me
CD 3
H
H
H
L A 1912
H
H
CD 3
CD 3
H
H
H
L A 1913
H
H
i Pr
CD 3
H
H
H
L A 1914
H
H
Ph
CD 3
H
H
H
L A 1915
H
H
Me
i Pr
H
H
H
L A 1916
H
H
CD 3
i Pr
H
H
H
L A 1917
H
H
i Pr
i Pr
H
H
H
L A 1918 L A 1919 L A 1920 L A 1921 L A 1922 L A 1923
H H H H H H
H H H H H H
Ph Me CD 3 i Pr Ph Me
i Pr Ph Ph Ph Ph H
H H H H H Me
H H H H H H
H H H H H H
L A 1924
H
H
CD 3
H
Me
H
H
L A 1925
H
H
i Pr
H
Me
H
H
L A 1926
H
H
Ph
H
Me
H
H
L A 1927
H
H
Me
H
CD 3
H
H
L A 1928
H
H
CD 3
H
CD 3
H
H
L A 1929
H
H
i Pr
H
CD 3
H
H
L A 1930
H
H
Ph
H
CD 3
H
H
L A 1931
H
H
Me
H
i Pr
H
H
L A 1932
H
H
CD 3
H
i Pr
H
H
L A 1933
H
H
i Pr
H
i Pr
H
H
L A 1934
H
H
Ph
H
i Pr
H
H
L A 1935
H
H
Me
H
Ph
H
H
L A 1936
H
H
CD 3
H
Ph
H
H
L A 1937
H
H
i Pr
H
Ph
H
H
L A 1938
H
H
Ph
H
Ph
H
H
L A 1939
Me
Me
H
Me
H
H
H
L A 1940
H
Me
Me
Me
H
H
H
L A 1941
CD 3
Me
H
Me
H
H
H
L A 1942
H
Me
CD 3
Me
H
H
H
L A 1943
i Pr
Me
H
Me
H
H
H
L A 1944
H
Me
i Pr
Me
H
H
H
L A 1945
Ph
Me
H
Me
H
H
H
L A 1946
H
Me
Ph
Me
H
H
H
L A 1947
Me
CD 3
H
CD 3
H
H
H
L A 1948
H
CD 3
Me
CD 3
H
H
H
L A 1949
CD 3
CD 3
H
CD 3
H
H
H
L A 1950
H
CD 3
CD 3
CD 3
H
H
H
L A 1951
i Pr
CD 3
H
CD 3
H
H
H
L A 1952
H
CD 3
i Pr
CD 3
H
H
H
L A 1953
Ph
CD 3
H
CD 3
H
H
H
L A 1954
H
CD 3
Ph
CD 3
H
H
H
L A 1955
Me
i Pr
H
i Pr
H
H
H
L A 1956
H
i Pr
Me
i Pr
H
H
H
L A 1957
CD 3
i Pr
H
i Pr
H
H
H
L A 1958
H
i Pr
CD 3
i Pr
H
H
H
L A 1959
i Pr
i Pr
H
i Pr
H
H
H
L A 1960
H
i Pr
i Pr
i Pr
H
H
H
L A 1961
Ph
i Pr
H
i Pr
H
H
H
L A 1962
H
i Pr
Ph
i Pr
H
H
H
L A 1963
Me
Ph
H
Ph
H
H
H
L A 1964
H
Ph
Me
Ph
H
H
H
L A 1965
CD 3
Ph
H
Ph
H
H
H
L A 1966
H
Ph
CD 3
Ph
H
H
H
L A 1967
i Pr
Ph
H
Ph
H
H
H
L A 1968
H
Ph
i Pr
Ph
H
H
H
L A 1969
Ph
Ph
H
Ph
H
H
H
L A 1970
H
Ph
Ph
Ph
H
H
H
L A 1971
H
H
H
H
H
H
H
L A 1972 L A 1973 L A 1974 L A 1975 L A 1976 L A 1977
Me H H H H CD 3
H Me H H H H
H H Me H H H
H H H Me H H
H H H H Me H
H H H H H H
H H H H H H
L A 1978
H
CD 3
H
H
H
H
H
L A 1979
H
H
CD 3
H
H
H
H
L A 1980
H
H
H
CD 3
H
H
H
L A 1981
H
H
H
H
CD 3
H
H
L A 1982
i Pr
H
H
H
H
H
H
L A 1983
H
i Pr
H
H
H
H
H
L A 1984
H
H
i Pr
H
H
H
H
L A 1985
H
H
H
i Pr
H
H
H
L A 1986
H
H
H
H
i Pr
H
H
L A 1987
Ph
H
H
H
H
H
H
L A 1988
H
Ph
H
H
H
H
H
L A 1989
H
H
Ph
H
H
H
H
L A 1990
H
H
H
Ph
H
H
H
L A 1991
H
H
H
H
Ph
H
H
L A 1992
Me
Me
H
H
H
H
H
L A 1993
Me
H
Me
H
H
H
H
L A 1994
Me
H
H
Me
H
H
H
L A 1995
Me
H
H
H
Me
H
H
L A 1996
Me
CD 3
H
H
H
H
H
L A 1997
Me
H
CD 3
H
H
H
H
L A 1998
Me
H
H
CD 3
H
H
H
L A 1999
Me
H
H
H
CD 3
H
H
L A 2000
Me
i Pr
H
H
H
H
H
L A 2001
Me
H
i Pr
H
H
H
H
L A 2002
Me
H
H
i Pr
H
H
H
L A 2003
Me
H
H
H
i Pr
H
H
L A 2004
Me
Ph
H
H
H
H
H
L A 2005
Me
H
Ph
H
H
H
H
L A 2006
Me
H
H
Ph
H
H
H
L A 2007
Me
H
H
H
Ph
H
H
L A 2008
CD 3
Me
H
H
H
H
H
L A 2009
CD 3
H
Me
H
H
H
H
L A 2010
CD 3
H
H
Me
H
H
H
L A 2011
CD 3
H
H
H
Me
H
H
L A 2012
CD 3
CD 3
H
H
H
H
H
L A 2013
CD 3
H
CD 3
H
H
H
H
L A 2014
CD 3
H
H
CD 3
H
H
H
L A 2015
CD 3
H
H
H
CD 3
H
H
L A 2016
CD 3
i Pr
H
H
H
H
H
L A 2017
CD 3
H
i Pr
H
H
H
H
L A 2018
CD 3
H
H
i Pr
H
H
H
L A 2019
CD 3
H
H
H
i Pr
H
H
L A 2020
CD 3
Ph
H
H
H
H
H
L A 2021
CD 3
H
Ph
H
H
H
H
L A 2022
CD 3
H
H
Ph
H
H
H
L A 2023
CD 3
H
H
H
Ph
H
H
L A 2024
i Pr
Me
H
H
H
H
H
L A 2025
i Pr
H
Me
H
H
H
H
L A 2026
i Pr
H
H
Me
H
H
H
L A 2027 L A 2028 L A 2029 L A 2030 L A 2031 L A 2032
i Pr i Pr i Pr i Pr i Pr i Pr
H CD 3 H H H i Pr
H H CD 3 H H H
H H H CD 3 H H
Me H H H CD 3 H
H H H H H H
H H H H H H
L A 2033
i Pr
H
i Pr
H
H
H
H
L A 2034
i Pr
H
H
i Pr
H
H
H
L A 2035
i Pr
H
H
H
i Pr
H
H
L A 2036
i Pr
Ph
H
H
H
H
H
L A 2037
i Pr
H
Ph
H
H
H
H
L A 2038
i Pr
H
H
Ph
H
H
H
L A 2039
i Pr
H
H
H
Ph
H
H
L A 2040
Ph
Me
H
H
H
H
H
L A 2041
Ph
H
Me
H
H
H
H
L A 2042
Ph
H
H
Me
H
H
H
L A 2043
Ph
H
H
H
Me
H
H
L A 2044
Ph
CD 3
H
H
H
H
H
L A 2045
Ph
H
CD 3
H
H
H
H
L A 2046
Ph
H
H
CD 3
H
H
H
L A 2047
Ph
H
H
H
CD 3
H
H
L A 2048
Ph
i Pr
H
H
H
H
H
L A 2049
Ph
H
i Pr
H
H
H
H
L A 2050
Ph
H
H
i Pr
H
H
H
L A 2051
Ph
H
H
H
i Pr
H
H
L A 2052
Ph
Ph
H
H
H
H
H
L A 2053
Ph
H
Ph
H
H
H
H
L A 2054
Ph
H
H
Ph
H
H
H
L A 2055
Ph
H
H
H
Ph
H
H
L A 2056
H
Me
Me
H
H
H
H
L A 2057
H
Me
H
Me
H
H
H
L A 2058
H
Me
H
H
Me
H
H
L A 2059
H
Me
CD 3
H
H
H
H
L A 2060
H
Me
H
CD 3
H
H
H
L A 2061
H
Me
H
H
CD 3
H
H
L A 2062
H
Me
i Pr
H
H
H
H
L A 2063
H
Me
H
i Pr
H
H
H
L A 2064
H
Me
H
H
i Pr
H
H
L A 2065
H
Me
Ph
H
H
H
H
L A 2066
H
Me
H
Ph
H
H
H
L A 2067
H
Me
H
H
Ph
H
H
L A 2068
H
CD 3
Me
H
H
H
H
L A 2069
H
CD 3
H
Me
H
H
H
L A 2070
H
CD 3
H
H
Me
H
H
L A 2071
H
CD 3
CD 3
H
H
H
H
L A 2072
H
CD 3
H
CD 3
H
H
H
L A 2073
H
CD 3
H
H
CD 3
H
H
L A 2074
H
CD 3
i Pr
H
H
H
H
L A 2075
H
CD 3
H
i Pr
H
H
H
L A 2076
H
CD 3
H
H
i Pr
H
H
L A 2077
H
CD 3
Ph
H
H
H
H
L A 2078
H
CD 3
H
Ph
H
H
H
L A 2079
H
CD 3
H
H
Ph
H
H
L A 2080
H
i Pr
Me
H
H
H
H
L A 2081
H
i Pr
H
Me
H
H
H
L A 2082 L A 2083 L A 2084 L A 2085 L A 2086 L A 2087
H H H H H H
i Pr i Pr i Pr i Pr i Pr i Pr
H CD 3 H H i Pr H
H H CD 3 H H i Pr
Me H H CD 3 H H
H H H H H H
H H H H H H
L A 2088
H
i Pr
H
H
i Pr
H
H
L A 2089
H
i Pr
Ph
H
H
H
H
L A 2090
H
i Pr
H
Ph
H
H
H
L A 2091
H
i Pr
H
H
Ph
H
H
L A 2092
H
Ph
Me
H
H
H
H
L A 2093
H
Ph
H
Me
H
H
H
L A 2094
H
Ph
H
H
Me
H
H
L A 2095
H
Ph
CD 3
H
H
H
H
L A 2096
H
Ph
H
CD 3
H
H
H
L A 2097
H
Ph
H
H
CD 3
H
H
L A 2098
H
Ph
i Pr
H
H
H
H
L A 2099
H
Ph
H
i Pr
H
H
H
L A 2100
H
Ph
H
H
i Pr
H
H
L A 2101
H
Ph
Ph
H
H
H
H
L A 2102
H
Ph
H
Ph
H
H
H
L A 2103
H
Ph
H
H
Ph
H
H
L A 2104
H
H
Me
Me
H
H
H
L A 2105
H
H
CD 3
Me
H
H
H
L A 2106
H
H
i Pr
Me
H
H
H
L A 2107
H
H
Ph
Me
H
H
H
L A 2108
H
H
Me
CD 3
H
H
H
L A 2109
H
H
CD 3
CD 3
H
H
H
L A 2110
H
H
i Pr
CD 3
H
H
H
L A 2111
H
H
Ph
CD 3
H
H
H
L A 2112
H
H
Me
i Pr
H
H
H
L A 2113
H
H
CD 3
i Pr
H
H
H
L A 2114
H
H
i Pr
i Pr
H
H
H
L A 2115
H
H
Ph
i Pr
H
H
H
L A 2116
H
H
Me
Ph
H
H
H
L A 2117
H
H
CD 3
Ph
H
H
H
L A 2118
H
H
i Pr
Ph
H
H
H
L A 2119
H
H
Ph
Ph
H
H
H
L A 2120
H
H
Me
H
Me
H
H
L A 2121
H
H
CD 3
H
Me
H
H
L A 2122
H
H
i Pr
H
Me
H
H
L A 2123
H
H
Ph
H
Me
H
H
L A 2124
H
H
Me
H
CD 3
H
H
L A 2125
H
H
CD 3
H
CD 3
H
H
L A 2126
H
H
i Pr
H
CD 3
H
H
L A 2127
H
H
Ph
H
CD 3
H
H
L A 2128
H
H
Me
H
i Pr
H
H
L A 2129
H
H
CD 3
H
i Pr
H
H
L A 2130
H
H
i Pr
H
i Pr
H
H
L A 2131
H
H
Ph
H
i Pr
H
H
L A 2132
H
H
Me
H
Ph
H
H
L A 2133
H
H
CD 3
H
Ph
H
H
L A 2134
H
H
i Pr
H
Ph
H
H
L A 2135
H
H
Ph
H
Ph
H
H
L A 2136
Me
Me
H
Me
H
H
H
L A 2137 L A 2138 L A 2139 L A 2140 L A 2141 L A 2142
H CD 3 H i Pr H Ph
Me Me Me Me Me Me
Me H CD 3 H i Pr H
Me Me Me Me Me Me
H H H H H H
H H H H H H
H H H H H H
L A 2143
H
Me
Ph
Me
H
H
H
L A 2144
Me
CD 3
H
CD 3
H
H
H
L A 2145
H
CD 3
Me
CD 3
H
H
H
L A 2146
CD 3
CD 3
H
CD 3
H
H
H
L A 2147
H
CD 3
CD 3
CD 3
H
H
H
L A 2148
i Pr
CD 3
H
CD 3
H
H
H
L A 2149
H
CD 3
i Pr
CD 3
H
H
H
L A 2150
Ph
CD 3
H
CD 3
H
H
H
L A 2151
H
CD 3
Ph
CD 3
H
H
H
L A 2152
Me
i Pr
H
i Pr
H
H
H
L A 2153
H
i Pr
Me
i Pr
H
H
H
L A 2154
CD 3
i Pr
H
i Pr
H
H
H
L A 2155
H
i Pr
CD 3
i Pr
H
H
H
L A 2156
i Pr
i Pr
H
i Pr
H
H
H
L A 2157
H
i Pr
i Pr
i Pr
H
H
H
L A 2158
Ph
i Pr
H
i Pr
H
H
H
L A 2159
H
i Pr
Ph
i Pr
H
H
H
L A 2160
Me
Ph
H
Ph
H
H
H
L A 2161
H
Ph
Me
Ph
H
H
H
L A 2162
CD 3
Ph
H
Ph
H
H
H
L A 2163
H
Ph
CD 3
Ph
H
H
H
L A 2164
i Pr
Ph
H
Ph
H
H
H
L A 2165
H
Ph
i Pr
Ph
H
H
H
L A 2166
Ph
Ph
H
Ph
H
H
H
L A 2167
H
Ph
Ph
Ph
H
H
H
L A 2168 L A 2169 L A 2170 L A 2171 L A 2172 L A 2173 L A 2174 L A 2175
H Me H H H H CD 3 H
H H Me H H H H CD 3
H H H Me H H H H
H H H H Me H H H
H H H H H Me H H
H H H H H H H H
H H H H H H H H
L A 2176
H
H
CD 3
H
H
H
H
L A 2177
H
H
H
CD 3
H
H
H
L A 2178
H
H
H
H
CD 3
H
H
L A 2179
i Pr
H
H
H
H
H
H
L A 2180
H
i Pr
H
H
H
H
H
L A 2181
H
H
i Pr
H
H
H
H
L A 2182
H
H
H
i Pr
H
H
H
L A 2183
H
H
H
H
i Pr
H
H
L A 2184
Ph
H
H
H
H
H
H
L A 2185
H
Ph
H
H
H
H
H
L A 2186
H
H
Ph
H
H
H
H
L A 2187
H
H
H
Ph
H
H
H
L A 2188
H
H
H
H
Ph
H
H
L A 2189
Me
Me
H
H
H
H
H
L A 2190
Me
H
Me
H
H
H
H
L A 2191
Me
H
H
Me
H
H
H
L A 2192 L A 2193 L A 2194 L A 2195 L A 2196 L A 2197 L A 2198 L A 2199
Me Me Me Me Me Me Me Me
H CD 3 H H H i Pr H H
H H CD 3 H H H i Pr H
H H H CD 3 H H H i Pr
Me H H H CD 3 H H H
H H H H H H H H
H H H H H H H H
L A 2200
Me
H
H
H
i Pr
H
H
L A 2201
Me
Ph
H
H
H
H
H
L A 2202
Me
H
Ph
H
H
H
H
L A 2203
Me
H
H
Ph
H
H
H
L A 2204
Me
H
H
H
Ph
H
H
L A 2205
CD 3
Me
H
H
H
H
H
L A 2206
CD 3
H
Me
H
H
H
H
L A 2207
CD 3
H
H
Me
H
H
H
L A 2208
CD 3
H
H
H
Me
H
H
L A 2209
CD 3
CD 3
H
H
H
H
H
L A 2210
CD 3
H
CD 3
H
H
H
H
L A 2211
CD 3
H
H
CD 3
H
H
H
L A 2212
CD 3
H
H
H
CD 3
H
H
L A 2213
CD 3
i Pr
H
H
H
H
H
L A 2214
CD 3
H
i Pr
H
H
H
H
L A 2215
CD 3
H
H
i Pr
H
H
H
L A 2216
CD 3
H
H
H
i Pr
H
H
L A 2217
CD 3
Ph
H
H
H
H
H
L A 2218
CD 3
H
Ph
H
H
H
H
L A 2219
CD 3
H
H
Ph
H
H
H
L A 2220
CD 3
H
H
H
Ph
H
H
L A 2221
i Pr
Me
H
H
H
H
H
L A 2222
i Pr
H
Me
H
H
H
H
L A 2223
i Pr
H
H
Me
H
H
H
L A 2224
i Pr
H
H
H
Me
H
H
L A 2225
i Pr
CD 3
H
H
H
H
H
L A 2226
i Pr
H
CD 3
H
H
H
H
L A 2227
i Pr
H
H
CD 3
H
H
H
L A 2228
i Pr
H
H
H
CD 3
H
H
L A 2229
i Pr
i Pr
H
H
H
H
H
L A 2230
i Pr
H
i Pr
H
H
H
H
L A 2231
i Pr
H
H
i Pr
H
H
H
L A 2232
i Pr
H
H
H
i Pr
H
H
L A 2233
i Pr
Ph
H
H
H
H
H
L A 2234
i Pr
H
Ph
H
H
H
H
L A 2235
i Pr
H
H
Ph
H
H
H
L A 2236
i Pr
H
H
H
Ph
H
H
L A 2237
Ph
Me
H
H
H
H
H
L A 2238
Ph
H
Me
H
H
H
H
L A 2239
Ph
H
H
Me
H
H
H
L A 2240
Ph
H
H
H
Me
H
H
L A 2241
Ph
CD 3
H
H
H
H
H
L A 2242
Ph
H
CD 3
H
H
H
H
L A 2243
Ph
H
H
CD 3
H
H
H
L A 2244
Ph
H
H
H
CD 3
H
H
L A 2245
Ph
i Pr
H
H
H
H
H
L A 2246
Ph
H
i Pr
H
H
H
H
L A 2247 L A 2248 L A 2249 L A 2250 L A 2251 L A 2252 L A 2253 L A 2254
Ph Ph Ph Ph Ph Ph H H
H H Ph H H H Me Me
H H H Ph H H Me H
i Pr H H H Ph H H Me
H i Pr H H H Ph H H
H H H H H H H H
H H H H H H H H
L A 2255
H
Me
H
H
Me
H
H
L A 2256
H
Me
CD 3
H
H
H
H
L A 2257
H
Me
H
CD 3
H
H
H
L A 2258
H
Me
H
H
CD 3
H
H
L A 2259
H
Me
i Pr
H
H
H
H
L A 2260
H
Me
H
i Pr
H
H
H
L A 2261
H
Me
H
H
i Pr
H
H
L A 2262
H
Me
Ph
H
H
H
H
L A 2263
H
Me
H
Ph
H
H
H
L A 2264
H
Me
H
H
Ph
H
H
L A 2265
H
CD 3
Me
H
H
H
H
L A 2266
H
CD 3
H
Me
H
H
H
L A 2267
H
CD 3
H
H
Me
H
H
L A 2268
H
CD 3
CD 3
H
H
H
H
L A 2269
H
CD 3
H
CD 3
H
H
H
L A 2270
H
CD 3
H
H
CD 3
H
H
L A 2271
H
CD 3
i Pr
H
H
H
H
L A 2272
H
CD 3
H
i Pr
H
H
H
L A 2273
H
CD 3
H
H
i Pr
H
H
L A 2274
H
CD 3
Ph
H
H
H
H
L A 2275
H
CD 3
H
Ph
H
H
H
L A 2276
H
CD 3
H
H
Ph
H
H
L A 2277
H
i Pr
Me
H
H
H
H
L A 2278
H
i Pr
H
Me
H
H
H
L A 2279
H
i Pr
H
H
Me
H
H
L A 2280
H
i Pr
CD 3
H
H
H
H
L A 2281
H
i Pr
H
CD 3
H
H
H
L A 2282
H
i Pr
H
H
CD 3
H
H
L A 2283
H
i Pr
i Pr
H
H
H
H
L A 2284
H
i Pr
H
i Pr
H
H
H
L A 2285
H
i Pr
H
H
i Pr
H
H
L A 2286
H
i Pr
Ph
H
H
H
H
L A 2287
H
i Pr
H
Ph
H
H
H
L A 2288
H
i Pr
H
H
Ph
H
H
L A 2289
H
Ph
Me
H
H
H
H
L A 2290
H
Ph
H
Me
H
H
H
L A 2291
H
Ph
H
H
Me
H
H
L A 2292
H
Ph
CD 3
H
H
H
H
L A 2293
H
Ph
H
CD 3
H
H
H
L A 2294
H
Ph
H
H
CD 3
H
H
L A 2295
H
Ph
i Pr
H
H
H
H
L A 2296
H
Ph
H
i Pr
H
H
H
L A 2297
H
Ph
H
H
i Pr
H
H
L A 2298
H
Ph
Ph
H
H
H
H
L A 2299
H
Ph
H
Ph
H
H
H
L A 2300
H
Ph
H
H
Ph
H
H
L A 2301
H
H
Me
Me
H
H
H
L A 2302 L A 2303 L A 2304 L A 2305 L A 2306 L A 2307 L A 2308 L A 2309
H H H H H H H H
H H H H H H H H
CD 3 i Pr Ph Me CD 3 i Pr Ph Me
Me Me Me CD 3 CD 3 CD 3 CD 3 i Pr
H H H H H H H H
H H H H H H H H
H H H H H H H H
L A 2310
H
H
CD 3
i Pr
H
H
H
L A 2311
H
H
i Pr
i Pr
H
H
H
L A 2312
H
H
Ph
i Pr
H
H
H
L A 2313
H
H
Me
Ph
H
H
H
L A 2314
H
H
CD 3
Ph
H
H
H
L A 2315
H
H
i Pr
Ph
H
H
H
L A 2316
H
H
Ph
Ph
H
H
H
L A 2317
H
H
Me
H
Me
H
H
L A 2318
H
H
CD 3
H
Me
H
H
L A 2319
H
H
i Pr
H
Me
H
H
L A 2320
H
H
Ph
H
Me
H
H
L A 2321
H
H
Me
H
CD 3
H
H
L A 2322
H
H
CD 3
H
CD 3
H
H
L A 2323
H
H
i Pr
H
CD 3
H
H
L A 2324
H
H
Ph
H
CD 3
H
H
L A 2325
H
H
Me
H
i Pr
H
H
L A 2326
H
H
CD 3
H
i Pr
H
H
L A 2327
H
H
i Pr
H
i Pr
H
H
L A 2328
H
H
Ph
H
i Pr
H
H
L A 2329
H
H
Me
H
Ph
H
H
L A 2330
H
H
CD 3
H
Ph
H
H
L A 2331
H
H
i Pr
H
Ph
H
H
L A 2332
H
H
Ph
H
Ph
H
H
L A 2333
Me
Me
H
Me
H
H
H
L A 2334
H
Me
Me
Me
H
H
H
L A 2335
CD 3
Me
H
Me
H
H
H
L A 2336
H
Me
CD 3
Me
H
H
H
L A 2337
i Pr
Me
H
Me
H
H
H
L A 2338
H
Me
i Pr
Me
H
H
H
L A 2339
Ph
Me
H
Me
H
H
H
L A 2340
H
Me
Ph
Me
H
H
H
L A 2341
Me
CD 3
H
CD 3
H
H
H
L A 2342
H
CD 3
Me
CD 3
H
H
H
L A 2343
CD 3
CD 3
H
CD 3
H
H
H
L A 2344
H
CD 3
CD 3
CD 3
H
H
H
L A 2345
i Pr
CD 3
H
CD 3
H
H
H
L A 2346
H
CD 3
i Pr
CD 3
H
H
H
L A 2347
Ph
CD 3
H
CD 3
H
H
H
L A 2348
H
CD 3
Ph
CD 3
H
H
H
L A 2349
Me
i Pr
H
i Pr
H
H
H
L A 2350
H
i Pr
Me
i Pr
H
H
H
L A 2351
CD 3
i Pr
H
i Pr
H
H
H
L A 2352
H
i Pr
CD 3
i Pr
H
H
H
L A 2353
i Pr
i Pr
H
i Pr
H
H
H
L A 2354
H
i Pr
i Pr
i Pr
H
H
H
L A 2355
Ph
i Pr
H
i Pr
H
H
H
L A 2356
H
i Pr
Ph
i Pr
H
H
H
L A 2357 L A 2358 L A 2359 L A 2360 L A 2361 L A 2362 L A 2363 L A 2364
Me H CD 3 H i Pr H Ph H
Ph Ph Ph Ph Ph Ph Ph Ph
H Me H CD 3 H i Pr H Ph
Ph Ph Ph Ph Ph Ph Ph Ph
H H H H H H H H
H H H H H H H H
H H H H H H H H
L A 2365 L A 2366 L A 2367 L A 2368 L A 2369 L A 2370 L A 2371
H Me H H H H CD 3
H H Me H H H H
H H H Me H H H
H H H H Me H H
H H H H H Me H
H H H H H H H
H H H H H H H
L A 2372
H
CD 3
H
H
H
H
H
L A 2373
H
H
CD 3
H
H
H
H
L A 2374
H
H
H
CD 3
H
H
H
L A 2375
H
H
H
H
CD 3
H
H
L A 2376
i Pr
H
H
H
H
H
H
L A 2377
H
i Pr
H
H
H
H
H
L A 2378
H
H
i Pr
H
H
H
H
L A 2379
H
H
H
i Pr
H
H
H
L A 2380
H
H
H
H
i Pr
H
H
L A 2381
Ph
H
H
H
H
H
H
L A 2382
H
Ph
H
H
H
H
H
L A 2383
H
H
Ph
H
H
H
H
L A 2384
H
H
H
Ph
H
H
H
L A 2385
H
H
H
H
Ph
H
H
L A 2386
Me
Me
H
H
H
H
H
L A 2387
Me
H
Me
H
H
H
H
L A 2388
Me
H
H
Me
H
H
H
L A 2389
Me
H
H
H
Me
H
H
L A 2390
Me
CD 3
H
H
H
H
H
L A 2391
Me
H
CD 3
H
H
H
H
L A 2392
Me
H
H
CD 3
H
H
H
L A 2393
Me
H
H
H
CD 3
H
H
L A 2394
Me
i Pr
H
H
H
H
H
L A 2395
Me
H
i Pr
H
H
H
H
L A 2396
Me
H
H
i Pr
H
H
H
L A 2397
Me
H
H
H
i Pr
H
H
L A 2398
Me
Ph
H
H
H
H
H
L A 2399
Me
H
Ph
H
H
H
H
L A 2400
Me
H
H
Ph
H
H
H
L A 2401
Me
H
H
H
Ph
H
H
L A 2402
CD 3
Me
H
H
H
H
H
L A 2403
CD 3
H
Me
H
H
H
H
L A 2404
CD 3
H
H
Me
H
H
H
L A 2405
CD 3
H
H
H
Me
H
H
L A 2406
CD 3
CD 3
H
H
H
H
H
L A 2407
CD 3
H
CD 3
H
H
H
H
L A 2408
CD 3
H
H
CD 3
H
H
H
L A 2409
CD 3
H
H
H
CD 3
H
H
L A 2410
CD 3
i Pr
H
H
H
H
H
L A 2411 L A 2412 L A 2413 L A 2414 L A 2415 L A 2416 L A 2417
CD 3 CD 3 CD 3 CD 3 CD 3 CD 3 CD 3
H H H Ph H H H
i Pr H H H Ph H H
H i Pr H H H Ph H
H H i Pr H H H Ph
H H H H H H H
H H H H H H H
L A 2418
i Pr
Me
H
H
H
H
H
L A 2419
i Pr
H
Me
H
H
H
H
L A 2420
i Pr
H
H
Me
H
H
H
L A 2421
i Pr
H
H
H
Me
H
H
L A 2422
i Pr
CD 3
H
H
H
H
H
L A 2423
i Pr
H
CD 3
H
H
H
H
L A 2424
i Pr
H
H
CD 3
H
H
H
L A 2425
i Pr
H
H
H
CD 3
H
H
L A 2426
i Pr
i Pr
H
H
H
H
H
L A 2427
i Pr
H
i Pr
H
H
H
H
L A 2428
i Pr
H
H
i Pr
H
H
H
L A 2429
i Pr
H
H
H
i Pr
H
H
L A 2430
i Pr
Ph
H
H
H
H
H
L A 2431
i Pr
H
Ph
H
H
H
H
L A 2432
i Pr
H
H
Ph
H
H
H
L A 2433
i Pr
H
H
H
Ph
H
H
L A 2434
Ph
Me
H
H
H
H
H
L A 2435
Ph
H
Me
H
H
H
H
L A 2436
Ph
H
H
Me
H
H
H
L A 2437
Ph
H
H
H
Me
H
H
L A 2438
Ph
CD 3
H
H
H
H
H
L A 2439
Ph
H
CD 3
H
H
H
H
L A 2440
Ph
H
H
CD 3
H
H
H
L A 2441
Ph
H
H
H
CD 3
H
H
L A 2442
Ph
i Pr
H
H
H
H
H
L A 2443
Ph
H
i Pr
H
H
H
H
L A 2444
Ph
H
H
i Pr
H
H
H
L A 2445
Ph
H
H
H
i Pr
H
H
L A 2446
Ph
Ph
H
H
H
H
H
L A 2447
Ph
H
Ph
H
H
H
H
L A 2448
Ph
H
H
Ph
H
H
H
L A 2449
Ph
H
H
H
Ph
H
H
L A 2450
H
Me
Me
H
H
H
H
L A 2451
H
Me
H
Me
H
H
H
L A 2452
H
Me
H
H
Me
H
H
L A 2453
H
Me
CD 3
H
H
H
H
L A 2454
H
Me
H
CD 3
H
H
H
L A 2455
H
Me
H
H
CD 3
H
H
L A 2456
H
Me
i Pr
H
H
H
H
L A 2457
H
Me
H
i Pr
H
H
H
L A 2458
H
Me
H
H
i Pr
H
H
L A 2459
H
Me
Ph
H
H
H
H
L A 2460
H
Me
H
Ph
H
H
H
L A 2461
H
Me
H
H
Ph
H
H
L A 2462
H
CD 3
Me
H
H
H
H
L A 2463
H
CD 3
H
Me
H
H
H
L A 2464
H
CD 3
H
H
Me
H
H
L A 2465
H
CD 3
CD 3
H
H
H
H
L A 2466 L A 2467 L A 2468 L A 2469 L A 2470 L A 2471 L A 2472
H H H H H H H
CD 3 CD 3 CD 3 CD 3 CD 3 CD 3 CD 3
H H i Pr H H Ph H
CD 3 H H i Pr H H Ph
H CD 3 H H i Pr H H
H H H H H H H
H H H H H H H
L A 2473
H
CD 3
H
H
Ph
H
H
L A 2474
H
i Pr
Me
H
H
H
H
L A 2475
H
i Pr
H
Me
H
H
H
L A 2476
H
i Pr
H
H
Me
H
H
L A 2477
H
i Pr
CD 3
H
H
H
H
L A 2478
H
i Pr
H
CD 3
H
H
H
L A 2479
H
i Pr
H
H
CD 3
H
H
L A 2480
H
i Pr
i Pr
H
H
H
H
L A 2481
H
i Pr
H
i Pr
H
H
H
L A 2482
H
i Pr
H
H
i Pr
H
H
L A 2483
H
i Pr
Ph
H
H
H
H
L A 2484
H
i Pr
H
Ph
H
H
H
L A 2485
H
i Pr
H
H
Ph
H
H
L A 2486
H
Ph
Me
H
H
H
H
L A 2487
H
Ph
H
Me
H
H
H
L A 2488
H
Ph
H
H
Me
H
H
L A 2489
H
Ph
CD 3
H
H
H
H
L A 2490
H
Ph
H
CD 3
H
H
H
L A 2491
H
Ph
H
H
CD 3
H
H
L A 2492
H
Ph
i Pr
H
H
H
H
L A 2493
H
Ph
H
i Pr
H
H
H
L A 2494
H
Ph
H
H
i Pr
H
H
L A 2495
H
Ph
Ph
H
H
H
H
L A 2496
H
Ph
H
Ph
H
H
H
L A 2497
H
Ph
H
H
Ph
H
H
L A 2498
H
H
Me
Me
H
H
H
L A 2499
H
H
CD 3
Me
H
H
H
L A 2500
H
H
i Pr
Me
H
H
H
L A 2501
H
H
Ph
Me
H
H
H
L A 2502
H
H
Me
CD 3
H
H
H
L A 2503
H
H
CD 3
CD 3
H
H
H
L A 2504
H
H
i Pr
CD 3
H
H
H
L A 2505
H
H
Ph
CD 3
H
H
H
L A 2506
H
H
Me
i Pr
H
H
H
L A 2507
H
H
CD 3
i Pr
H
H
H
L A 2508
H
H
i Pr
i Pr
H
H
H
L A 2509
H
H
Ph
i Pr
H
H
H
L A 2510
H
H
Me
Ph
H
H
H
L A 2511
H
H
CD 3
Ph
H
H
H
L A 2512
H
H
i Pr
Ph
H
H
H
L A 2513
H
H
Ph
Ph
H
H
H
L A 2514
H
H
Me
H
Me
H
H
L A 2515
H
H
CD 3
H
Me
H
H
L A 2516
H
H
i Pr
H
Me
H
H
L A 2517
H
H
Ph
H
Me
H
H
L A 2518
H
H
Me
H
CD 3
H
H
L A 2519
H
H
CD 3
H
CD 3
H
H
L A 2520
H
H
i Pr
H
CD 3
H
H
L A 2521 L A 2522 L A 2523 L A 2524 L A 2525 L A 2526 L A 2527
H H H H H H H
H H H H H H H
Ph Me CD 3 i Pr Ph Me CD 3
H H H H H H H
CD 3 i Pr i Pr i Pr i Pr Ph Ph
H H H H H H H
H H H H H H H
L A 2528
H
H
i Pr
H
Ph
H
H
L A 2529
H
H
Ph
H
Ph
H
H
L A 2530
Me
Me
H
Me
H
H
H
L A 2531
H
Me
Me
Me
H
H
H
L A 2532
CD 3
Me
H
Me
H
H
H
L A 2533
H
Me
CD 3
Me
H
H
H
L A 2534
i Pr
Me
H
Me
H
H
H
L A 2535
H
Me
i Pr
Me
H
H
H
L A 2536
Ph
Me
H
Me
H
H
H
L A 2537
H
Me
Ph
Me
H
H
H
L A 2538
Me
CD 3
H
CD 3
H
H
H
L A 2539
H
CD 3
Me
CD 3
H
H
H
L A 2540
CD 3
CD 3
H
CD 3
H
H
H
L A 2541
H
CD 3
CD 3
CD 3
H
H
H
L A 2542
i Pr
CD 3
H
CD 3
H
H
H
L A 2543
H
CD 3
i Pr
CD 3
H
H
H
L A 2544
Ph
CD 3
H
CD 3
H
H
H
L A 2545
H
CD 3
Ph
CD 3
H
H
H
L A 2546
Me
i Pr
H
i Pr
H
H
H
L A 2547
H
i Pr
Me
i Pr
H
H
H
L A 2548
CD 3
i Pr
H
i Pr
H
H
H
L A 2549
H
i Pr
CD 3
i Pr
H
H
H
L A 2550
i Pr
i Pr
H
i Pr
H
H
H
L A 2551
H
i Pr
i Pr
i Pr
H
H
H
L A 2552
Ph
i Pr
H
i Pr
H
H
H
L A 2553
H
i Pr
Ph
i Pr
H
H
H
L A 2554
Me
Ph
H
Ph
H
H
H
L A 2555
H
Ph
Me
Ph
H
H
H
L A 2556
CD 3
Ph
H
Ph
H
H
H
L A 2557
H
Ph
CD 3
Ph
H
H
H
L A 2558
i Pr
Ph
H
Ph
H
H
H
L A 2559
H
Ph
i Pr
Ph
H
H
H
L A 2560
Ph
Ph
H
Ph
H
H
H
L A 2561
H
Ph
Ph
Ph
H
H
H
L A 2562 L A 2563 L A 2564 L A 2565 L A 2566 L A 2567
H Me H H H H
H H Me H H H
H H H Me H H
H H H H Me H
H H H H H Me
H H H H H H
H H H H H H
L A 2568
CD 3
H
H
H
H
H
H
L A 2569
H
CD 3
H
H
H
H
H
L A 2570
H
H
CD 3
H
H
H
H
L A 2571
H
H
H
CD 3
H
H
H
L A 2572
H
H
H
H
CD 3
H
H
L A 2573
i Pr
H
H
H
H
H
H
L A 2574
H
i Pr
H
H
H
H
H
L A 2575
H
H
i Pr
H
H
H
H
L A 2576 L A 2577 L A 2578 L A 2579 L A 2580 L A 2581
H H Ph H H H
H H H Ph H H
H H H H Ph H
i Pr H H H H Ph
H i Pr H H H H
H H H H H H
H H H H H H
L A 2582
H
H
H
H
Ph
H
H
L A 2583
Me
Me
H
H
H
H
H
L A 2584
Me
H
Me
H
H
H
H
L A 2585
Me
H
H
Me
H
H
H
L A 2586
Me
H
H
H
Me
H
H
L A 2587
Me
CD 3
H
H
H
H
H
L A 2588
Me
H
CD 3
H
H
H
H
L A 2589
Me
H
H
CD 3
H
H
H
L A 2590
Me
H
H
H
CD 3
H
H
L A 2591
Me
i Pr
H
H
H
H
H
L A 2592
Me
H
i Pr
H
H
H
H
L A 2593
Me
H
H
i Pr
H
H
H
L A 2594
Me
H
H
H
i Pr
H
H
L A 2595
Me
Ph
H
H
H
H
H
L A 2596
Me
H
Ph
H
H
H
H
L A 2597
Me
H
H
Ph
H
H
H
L A 2598
Me
H
H
H
Ph
H
H
L A 2599
CD 3
Me
H
H
H
H
H
L A 2600
CD 3
H
Me
H
H
H
H
L A 2601
CD 3
H
H
Me
H
H
H
L A 2602
CD 3
H
H
H
Me
H
H
L A 2603
CD 3
CD 3
H
H
H
H
H
L A 2604
CD 3
H
CD 3
H
H
H
H
L A 2605
CD 3
H
H
CD 3
H
H
H
L A 2606
CD 3
H
H
H
CD 3
H
H
L A 2607
CD 3
i Pr
H
H
H
H
H
L A 2608
CD 3
H
i Pr
H
H
H
H
L A 2609
CD 3
H
H
i Pr
H
H
H
L A 2610
CD 3
H
H
H
i Pr
H
H
L A 2611
CD 3
Ph
H
H
H
H
H
L A 2612
CD 3
H
Ph
H
H
H
H
L A 2613
CD 3
H
H
Ph
H
H
H
L A 2614
CD 3
H
H
H
Ph
H
H
L A 2615
i Pr
Me
H
H
H
H
H
L A 2616
i Pr
H
Me
H
H
H
H
L A 2617
i Pr
H
H
Me
H
H
H
L A 2618
i Pr
H
H
H
Me
H
H
L A 2619
i Pr
CD 3
H
H
H
H
H
L A 2620
i Pr
H
CD 3
H
H
H
H
L A 2621
i Pr
H
H
CD 3
H
H
H
L A 2622
i Pr
H
H
H
CD 3
H
H
L A 2623
i Pr
i Pr
H
H
H
H
H
L A 2624
i Pr
H
i Pr
H
H
H
H
L A 2625
i Pr
H
H
i Pr
H
H
H
L A 2626
i Pr
H
H
H
i Pr
H
H
L A 2627
i Pr
Ph
H
H
H
H
H
L A 2628
i Pr
H
Ph
H
H
H
H
L A 2629
i Pr
H
H
Ph
H
H
H
L A 2630
i Pr
H
H
H
Ph
H
H
L A 2631 L A 2632 L A 2633 L A 2634 L A 2635 L A 2636
Ph Ph Ph Ph Ph Ph
Me H H H CD 3 H
H Me H H H CD 3
H H Me H H H
H H H Me H H
H H H H H H
H H H H H H
L A 2637
Ph
H
H
CD 3
H
H
H
L A 2638
Ph
H
H
H
CD 3
H
H
L A 2639
Ph
i Pr
H
H
H
H
H
L A 2640
Ph
H
i Pr
H
H
H
H
L A 2641
Ph
H
H
i Pr
H
H
H
L A 2642
Ph
H
H
H
i Pr
H
H
L A 2643
Ph
Ph
H
H
H
H
H
L A 2644
Ph
H
Ph
H
H
H
H
L A 2645
Ph
H
H
Ph
H
H
H
L A 2646
Ph
H
H
H
Ph
H
H
L A 2647
H
Me
Me
H
H
H
H
L A 2648
H
Me
H
Me
H
H
H
L A 2649
H
Me
H
H
Me
H
H
L A 2650
H
Me
CD 3
H
H
H
H
L A 2651
H
Me
H
CD 3
H
H
H
L A 2652
H
Me
H
H
CD 3
H
H
L A 2653
H
Me
i Pr
H
H
H
H
L A 2654
H
Me
H
i Pr
H
H
H
L A 2655
H
Me
H
H
i Pr
H
H
L A 2656
H
Me
Ph
H
H
H
H
L A 2657
H
Me
H
Ph
H
H
H
L A 2658
H
Me
H
H
Ph
H
H
L A 2659
H
CD 3
Me
H
H
H
H
L A 2660
H
CD 3
H
Me
H
H
H
L A 2661
H
CD 3
H
H
Me
H
H
L A 2662
H
CD 3
CD 3
H
H
H
H
L A 2663
H
CD 3
H
CD 3
H
H
H
L A 2664
H
CD 3
H
H
CD 3
H
H
L A 2665
H
CD 3
i Pr
H
H
H
H
L A 2666
H
CD 3
H
i Pr
H
H
H
L A 2667
H
CD 3
H
H
i Pr
H
H
L A 2668
H
CD 3
Ph
H
H
H
H
L A 2669
H
CD 3
H
Ph
H
H
H
L A 2670
H
CD 3
H
H
Ph
H
H
L A 2671
H
i Pr
Me
H
H
H
H
L A 2672
H
i Pr
H
Me
H
H
H
L A 2673
H
i Pr
H
H
Me
H
H
L A 2674
H
i Pr
CD 3
H
H
H
H
L A 2675
H
i Pr
H
CD 3
H
H
H
L A 2676
H
i Pr
H
H
CD 3
H
H
L A 2677
H
i Pr
i Pr
H
H
H
H
L A 2678
H
i Pr
H
i Pr
H
H
H
L A 2679
H
i Pr
H
H
i Pr
H
H
L A 2680
H
i Pr
Ph
H
H
H
H
L A 2681
H
i Pr
H
Ph
H
H
H
L A 2682
H
i Pr
H
H
Ph
H
H
L A 2683
H
Ph
Me
H
H
H
H
L A 2684
H
Ph
H
Me
H
H
H
L A 2685
H
Ph
H
H
Me
H
H
L A 2686 L A 2687 L A 2688 L A 2689 L A 2690 L A 2691
H H H H H H
Ph Ph Ph Ph Ph Ph
CD 3 H H i Pr H H
H CD 3 H H i Pr H
H H CD 3 H H i Pr
H H H H H H
H H H H H H
L A 2692
H
Ph
Ph
H
H
H
H
L A 2693
H
Ph
H
Ph
H
H
H
L A 2694
H
Ph
H
H
Ph
H
H
L A 2695
H
H
Me
Me
H
H
H
L A 2696
H
H
CD 3
Me
H
H
H
L A 2697
H
H
i Pr
Me
H
H
H
L A 2698
H
H
Ph
Me
H
H
H
L A 2699
H
H
Me
CD 3
H
H
H
L A 2700
H
H
CD 3
CD 3
H
H
H
L A 2701
H
H
i Pr
CD 3
H
H
H
L A 2702
H
H
Ph
CD 3
H
H
H
L A 2703
H
H
Me
i Pr
H
H
H
L32704
H
H
CD 3
i Pr
H
H
H
L A 2705
H
H
i Pr
i Pr
H
H
H
L A 2706
H
H
Ph
i Pr
H
H
H
L A 2707
H
H
Me
Ph
H
H
H
L A 2708
H
H
CD 3
Ph
H
H
H
L A 2709
H
H
i Pr
Ph
H
H
H
L A 2710
H
H
Ph
Ph
H
H
H
L A 2711
H
H
Me
H
Me
H
H
L A 2712
H
H
CD 3
H
Me
H
H
L A 2713
H
H
i Pr
H
Me
H
H
L A 2714
H
H
Ph
H
Me
H
H
L A 2715
H
H
Me
H
CD 3
H
H
L A 2716
H
H
CD 3
H
CD 3
H
H
L A 2717
H
H
i Pr
H
CD 3
H
H
L A 2718
H
H
Ph
H
CD 3
H
H
L A 2719
H
H
Me
H
i Pr
H
H
L A 2720
H
H
CD 3
H
i Pr
H
H
L A 2721
H
H
i Pr
H
i Pr
H
H
L A 2722
H
H
Ph
H
i Pr
H
H
L A 2723
H
H
Me
H
Ph
H
H
L A 2724
H
H
CD 3
H
Ph
H
H
L A 2725
H
H
i Pr
H
Ph
H
H
L A 2726
H
H
Ph
H
Ph
H
H
L A 2727
Me
Me
H
Me
H
H
H
L A 2728
H
Me
Me
Me
H
H
H
L A 2729
CD 3
Me
H
Me
H
H
H
L A 2730
H
Me
CD 3
Me
H
H
H
L A 2731
i Pr
Me
H
Me
H
H
H
L A 2732
H
Me
i Pr
Me
H
H
H
L A 2733
Ph
Me
H
Me
H
H
H
L A 2734
H
Me
Ph
Me
H
H
H
L A 2735
Me
CD 3
H
CD 3
H
H
H
L A 2736
H
CD 3
Me
CD 3
H
H
H
L A 2737
CD 3
CD 3
H
CD 3
H
H
H
L A 2738
H
CD 3
CD 3
CD 3
H
H
H
L A 2739
i Pr
CD 3
H
CD 3
H
H
H
L A 2740
H
CD 3
i Pr
CD 3
H
H
H
L A 2741 L A 2742 L A 2743 L A 2744 L A 2745 L A 2746
Ph H Me H CD 3 H
CD 3 CD 3 i Pr i Pr i Pr i Pr
H Ph H Me H CD 3
CD 3 CD 3 i Pr i Pr i Pr i Pr
H H H H H H
H H H H H H
H H H H H H
L A 2747
i Pr
i Pr
H
i Pr
H
H
H
L A 2748
H
i Pr
i Pr
i Pr
H
H
H
L A 2749
Ph
i Pr
H
i Pr
H
H
H
L A 2750 L A 2751 L A 2752 L A 2753 L A 2754 L A 2755
H Me H CD 3 H i Pr
i Pr Ph Ph Ph Ph Ph
Ph H Me H CD 3 H
i Pr Ph Ph Ph Ph Ph
H H H H H H
H H H H H H
H H H H H H
L A 2756
H
Ph
i Pr
Ph
H
H
H
L A 2757
Ph
Ph
H
Ph
H
H
H
L A 2758
H
Ph
Ph
Ph
H
H
H.
8. The compound of claim 1 , wherein the ligand L is selected from the group consisting of:
9. The compound of claim 1 , wherein ligand L is selected from the group consisting of:
10. The compound of claim 7 , wherein the compound is selected from the group consisting of Compound By having the formula Ir(L Ai )(L j ) 2 or selected from the group consisting of Compound Cz having the formula Ir(L Ai ) 2 (L j );
wherein y is an integer defined by y=391+j-39, and z is an integer defined by z=39i+j-39, wherein i is an integer from 1 to 2758, and j is an integer from 1 to 39; and
wherein Compound By denotes Compound B 1 to Compound B 107,562 , Compound Cz denotes Compound C 1 to C 107,562 , L Ai denotes L A1 to L A2758 , and
L j denotes L 1 to L 39 having the following structures:
wherein L A 1 through L A 2758 are as defined above.
11. The compound of claim 1 , wherein the compound has a structure of Formula 2:
wherein M is Pt;
wherein A 1 and A 2 are each independently a first linking group selected from the group consisting of —CR′R″—CR′R″—, —CR′R′—CR″R″—, —CH 2 —CH 2 —, —CR′R′—CR′R′—CR′R′—, —CR′R″—NR′—, —CR′═CR′—CR′R′—, —O—SiR′R′—, —CR′R″—S—, —CR′R″—O—, and —CR′R″—SiR′R′—,
wherein each R′ is independently selected from the group consisting of H, D, alkyl, cycloalkyl, aryl, heteroaryl, and combinations thereof,
wherein each R″ is independently selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, and combinations thereof,
wherein R′s and R″s are optionally connected to form a saturated five membered ring or a saturated six membered ring, and combinations thereof,
wherein R 1b to R 1f and R 2b to R 2f are each independently selected from the group consisting of hydrogen, deuterium, alkyl, cycloalkyl, heteroalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aralkyl, CN, CF 3 , CO 2 R, C(O)R, C(O)NR 2 , NR 2 , NO 2 , OR, SR, SO 2 , SOR, SO 3 R, halo, aryl, heteroaryl, a heterocyclic group, and combinations thereof;
wherein any one of the ring atoms to which R 1b to R 1f and R 2b to R 2f are attached may be replaced with a nitrogen atom, wherein when the ring atom is replaced with a nitrogen atom the corresponding R group is not present; and
wherein R ab and R ac and/or R ga and R gb may bond to form a second linking group having one to three linking atoms each independently selected from the group consisting of B, N, P, O, S, Se, C, Si, Ge or combinations thereof.
12. The compound of claim 1 , wherein the compound has Formula 3:
wherein M is Pt;
wherein L 3 is selected from the group consisting of a single bond, BR, NR, PR, O, S, Se, C—O, S—O, SO 2 , CR 1 R 2 , SiR 1 R 2 , and GeR 1 R 2 ;
wherein R 3a -R 3f , are each independently selected from the group consisting of hydrogen, deuterium, alkyl, cycloalkyl, heteroalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aralkyl, CN, CF 3 , CO 2 R, C(O)R, C(O)NR 2 , NR 2 , NO 2 , OR, SR, SO 2 , SOR, SO 3 R, halo, aryl, heteroaryl, a heterocyclic group, and combinations thereof;
wherein any two adjacent R 1f , R 3a , R 3c , R 3d , R 1 and R 2 are optionally joined to form a ring; wherein L 2 and R 1f , L 2 and R 3a , or L 2 and both R 1f and R 3a are optionally joined to form one or more rings; and
wherein L 3 and R 3c , L 3 and R 3d , or L 3 and both R 3c and R 3d are optionally joined to form one or more rings.
13. A formulation comprising a compound according to claim 1 .
14. The compound of claim 1 , wherein the compound is selected from the group consisting of:
15. The compound of claim 1 , wherein the linking group A is independently selected from the group consisting of —CR′R″—CR′R″—, —CR′R′—CR″R″—, and —CH 2 —CH 2 —.
16. The compound of claim 1 , wherein the ligand L is selected from the group consisting of:
wherein each X 1 to X 13 are independently selected from the group consisting of carbon and nitrogen;
wherein X is selected from the group consisting of BR′, NR′, PR′, O, S, Se, C═O, S═O, SO 2 , CR′R″, SiR′R″, and GeR′R″;
wherein R′ and R″ are optionally fused or joined to form a ring;
wherein each R a , R b , R c , and R d may represent from mono substitution to the possible maximum number of substitution, or no substitution;
wherein R′, R″, R a , R b , R c , and R d are each independently selected from the group consisting of hydrogen, deuterium, halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof; and
wherein any two adjacent substituents of R a , R b , R c , and R d are optionally fused or joined to form a ring or form a multidentate ligand.
17. An organic light emitting device (OLED) comprising:
an anode;
a cathode;
an organic layer disposed between the anode and the cathode, wherein the organic layer comprising a compound having a structure (L A ) n ML m according to Formula 1:
wherein M is a metal having an atomic weight greater than 40, n has a value of at least land m+n is the maximum number of ligands that may be attached to the metal;
wherein A is a linking group selected from the group consisting of —CR′R″—CR′R″—, —CR′R′—CR″R″—, —CH 2 —CH 2 —, —CR′R′—CR′R′—CR′R′—, —CR′R″—NR′—, —CR′═CR′—CR′R′—, —O—SiR′R′—, —CR′R″—S—, —CR′R″—O—, and —CR′R″—SiR′R′—,
wherein each R′ is independently selected from the group consisting of H, D, alkyl, cycloalkyl, aryl, heteroaryl, and combinations thereof,
wherein each R″ is independently selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, and combinations thereof,
wherein R′s and R″s are optionally connected to form a saturated five membered ring or a saturated six membered ring, and combinations thereof,
wherein R 1a to R 1g are each independently selected from the group consisting of hydrogen, deuterium, alkyl, cycloalkyl, heteroalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aralkyl, CN, CF 3 , CO 2 R, C(O)R, C(O)NR 2 , NR 2 , NO 2 , OR, SR, SO 2 , SOR, SO 3 R, halo, aryl, heteroaryl, a heterocyclic group, and combinations thereof;
wherein each R is independently selected from the group consisting of hydrogen, deuterium, halo, alkyl, cycloalkyl, heteroalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aralkyl, aryl, heteroaryl, and combinations thereof;
wherein any one of the ring atoms to which R 1b to R 1g are attached may be replaced with a nitrogen atom, wherein when the ring atom is replaced with a nitrogen atom the corresponding R group is not present;
wherein L is a substituted or unsubstituted cyclometallated ligand,
wherein L can be joined to R 1g through a linking group L 2 ;
wherein L 2 is selected from the group consisting of a single bond, BR, NR, PR, O, S, Se, C—O, S—O, SO 2 , CR 1 R 2 , SiR 1 R 2 , and GeR 1 R 2 ;
wherein R 1 and R 2 can be same or different, and are independently selected from the group consisting of hydrogen, deuterium, alkyl, cycloalkyl, aryl, heteroaryl, and combinations thereof; wherein any adjacent R 1 and R 2 are optionally connected to form a saturated five membered ring or a saturated six membered ring.
18. The OLED of claim 17 , wherein the OLED is incorporated into a device selected from the group consisting of a consumer product, an electronic component module, and a lighting panel.
19. The OLED of claim 17 , wherein the organic layer further comprises a host, wherein host comprises at least one chemical group selected from the group consisting of triphenylene, carbazole, dibenzothiophene, dibenzofuran, dibenzoselenophene, azatriphenylene, azacarbazole, aza-dibenzothiophene, aza-dibenzofuran, and aza-dibenzoselenophene.