Adhesive-coated sutures
The field of the disclosure relates generally to sutures and, more specifically, to enhancing suture repair mechanics using adhesives.
1. A suture coated with an adhesive, the adhesive comprising a suture-binding domain, a compliant domain, and a tissue-binding domain linked in series, wherein the compliant domain comprises an elastin moiety linker molecule, wherein the tissue-binding domain comprises a collagen-binding domain, and wherein the collagen-binding domain comprises integrin.
2. The suture according to claim 1 , wherein the adhesive is a protein-based bioadhesive.
3. The suture according to claim 1 , wherein the adhesive is biodegradable.
4. The suture according to claim 1 , wherein the suture-binding domain comprises a silk-binding domain.
5. The suture according to claim 1 , wherein the compliant domain further comprises a protein sequence.
6. A method of surgical repair, the method comprising:
coating a suture with an adhesive, the coating comprising a suture-binding domain, a compliant domain, and a tissue-binding domain linked in series, wherein the compliant domain comprises an elastin moiety linker molecule, wherein the tissue-binding domain comprises a collagen-binding domain, and wherein the collagen-binding domain comprises integrin, and wherein the coating further comprises a protective layer,
applying the suture to a part of a body, activating the adhesive layer by applying an activating stimulus to the part of the body, and binding the suture to the part of the body.
7. The method of surgical repair according to claim 6 , further comprising treating the coated suture with methanol prior to applying the suture to the part of the body.
8. The method of surgical repair according to claim 6 , wherein activating the adhesive by applying an activating stimulus comprises applying heat to the part of the body.
9. The method of surgical repair according to claim 6 , wherein activating the adhesive by applying an activating stimulus comprises applying near infrared radiation to the part of the body.
10. The method of surgical repair according to claim 6 , wherein coating the suture with the adhesive comprises coating the suture with a protein-based bioadhesive.
11. The method of surgical repair according to claim 6 , wherein coating the suture with the adhesive comprises coating the suture with a biodegradable adhesive.
12. An adhesive-coated suture, wherein the adhesive comprises a suture-binding domain, a compliant domain, and a tissue-binding domain linked in series, wherein the compliant domain comprises an elastin moiety linker molecule, wherein the tissue-binding domain comprises a collagen-binding domain, and wherein the collagen-binding domain comprises integrin, and wherein the adhesive is configured to reduce a shear stress concentration at one more or more anchor points of the suture.
13. The adhesive-coated suture according to claim 12 , wherein the adhesive is a protein-based bioadhesive.
14. The adhesive-coated suture according to claim 12 , wherein the adhesive is biodegradable.
15. The adhesive-coated suture according to claim 12 , further comprising a protective layer.
16. The adhesive-coated suture according to claim 12 , wherein the adhesive is activated by applying heat.
17. The adhesive-coated suture according to claim 12 , wherein the adhesive is activated by applying near infrared radiation.
18. An adhesive-coated suture, comprising a suture-binding domain, a compliant domain, and a tissue-binding domain linked in series, wherein the compliant domain comprises an elastin moiety linker molecule, wherein the tissue-binding domain comprises a collagen-binding domain, and wherein the collagen-binding domain comprises integrin, and wherein a failure shear stress of the adhesive is greater than 106 Pa.