Methods and processes for application of drug delivery polymeric coatings
Polymeric coatings, their applications, and the methods of their preparation are described. The coatings may be used to confer desirable properties to the consumer and/or medical products. Also described are methods of loading therapeutic agents on the polymeric coatings and the applications of the drug eluting polymeric coatings thus obtained.
1. A method of coating a medical device surface, the method comprising:
providing the medical device, said medical device having a microstructure;
exposing a surface of the medical device to a coating formulation comprising:
0.005-80 wt % of a thiol monomer comprising a polythiol;
0.005-80 wt % of an unsaturated monomer, wherein the unsaturated monomer is triallyl isocyanurate or polyethylene glycol dimethacrylate; and
a therapeutic agent; and
inducing polymerization of the coating formulation to obtain a coated device surface that elutes the therapeutic agent.
2. The method of claim 1 , wherein the therapeutic agent is selected from rifampicin, minocycline, minocycline hydrochloride, minocycline hyclate, or any combination thereof.
3. The method of claim 1 , wherein the polythiol comprises pentaerythritol tetrakis(3-mercaptopropionate).
4. The method of claim 1 , wherein the thiol monomer is selected from: glyceryl 1,3-dithioglycolate, glycol dimercaptoacetate, ethoxylated-trimethylolpropan tri(3-mercaptopropionate), trimethylolpropane tris (3-mercaptopropionate), 4-mercaptomethyl-3,6-dithia-1,8-octanedithiol, pentaerythritol tetrakis (3-mercaptoacetate), trimethylolpropane tris (3-mercaptoacetate), 4-t-butyl-1,2-benzenedithiol, bis(2-mercaptoethyl)sulfide, 4,4′-thiodibenzenethiol, benzenedithiol, glycol dimercaptopropionate ethylene bis(3-mercaptopropionate), polythylene glycol dimercaptoacetate, polythylene glycol di(3-mercaptoacetate), (tetrahydrothiophene-2,5-diyl)dimethanethiol, bis(2-mercaptoethyl)sulfide, tris-(3-mercaptopropyl)isocyanurate, 1,2,3-trimercaptopropane, 2,2-bis(mercaptomethyl)-1,3-propanedithiol, 2,5-dimercaptomethyl-4-dithiane, 1,2,4-trimercaptomethyl benzene, 4,8-bis(mercaptomethyl)-3,6,9-trithia-1,11-undecanedithiol, 2-mercaptomethyl-2-methyl-1,3-propanedithiol, 1,8-dimercapto-3,6-dioxaoctane; 2,2′,2″-(2,4,6-trioxo-1,3,5-triazinane-1,3,5-triyl)tris(ethane-2,1-diyl) tris(3-mercaptopropanoate), or any combination thereof.
5. The method of claim 1 , wherein the coating formulation further comprises a radical scavenger selected from hydroquinone, tertbutyl cathetol, or a combination thereof.
6. The method of claim 1 , wherein the polythiol is pentaerythritol tetrakis (3-mercaptoacetate).
7. The method of claim 1 , wherein the polythiol is pentaerythritol tetrakis (3-mercaptoacetate) and the unsaturated monomer is triallyl isocyanurate.
8. The method of claim 1 , wherein the polythiol is pentaerythritol tetrakis (3-mercaptoacetate) and the unsaturated monomer is polyethylene glycol dimethacrylate.
9. The method of claim 1 , further comprising eluting the therapeutic agent from the coated device surface.
10. A method of coating a medical device surface, the method comprising:
providing the medical device, said medical device having a microstructure;
exposing a surface of the medical device to a coating formulation comprising:
0.005-80 wt % of pentaerythritol tetrakis (3-mercaptoacetate); and
0.005-80 wt % of an unsaturated monomer, wherein the unsaturated monomer is triallyl isocyanurate or polyethylene glycol dimethacrylate; and
inducing polymerization of the coating formulation to obtain a coated medical device surface that elutes a therapeutic agent.
11. The method of claim 10 , wherein the coating formulation further comprises the therapeutic agent.
12. The method of claim 10 , further comprising physically assisting the coating formulation to enter the microstructure of the medical device by applying an external force prior to inducing polymerization of the coating formulation.
13. The method of claim 12 , wherein the external force is a negative pressure.
14. The method of claim 12 , wherein the external force is a positive pressure.
15. The method of claim 10 , further comprising exposing the medical device to a solution comprising the therapeutic agent.
16. The method of claim 15 , wherein the exposing of the medical device to the solution comprising the therapeutic agent is performed at a reduced temperature from −50° C. to 0° C.