Minimally invasive repair of heart valve leaflets

1. A method of repairing a mitral valve in a beating heart of a patient, comprising:

inserting an external guide catheter through a vein of a patient and into a right atrium of a heart of a patient;

advancing the external guide catheter into a right ventricle of the patient's heart;

advancing an internal guide catheter through the external guide catheter and advancing the internal guide catheter into the right ventricle;

puncturing an interventricular septum in the patient's heart to create an opening between the right ventricle and the left ventricle;

advancing the internal guide catheter through the opening in the interventricular septum and into the left ventricle;

advancing a deployment catheter through the internal guide catheter and advancing the deployment catheter through the interventricular septum and into the left ventricle;

deploying a suture onto a mitral valve leaflet with the deployment catheter;

advancing a sealing device through the internal guide catheter to the interventricular septum; and

positioning the sealing device within the opening in the interventricular septum with the suture extending between the mitral valve leaflet that the suture is deployed onto and the sealing device.

2. The method of claim 1 , wherein the step of positioning the sealing device within the opening in the interventricular septum is done after the step of deploying a suture onto the mitral valve.

3. The method of claim 1 , wherein the step of deploying a suture onto the mitral valve with the deployment catheter includes:

capturing a mitral valve leaflet with a clamping mechanism of the deployment catheter; and

inserting the suture through the mitral valve leaflet with a needle of the deployment catheter.

4. The method of claim 1 , further comprising:

positioning the sealing device within the opening in the interventricular septum such that a proximal end of the suture extends from the mitral valve through the interventricular septum.

5. The method of claim 4 , further comprising:

advancing a cutting catheter having a cutting tool through the internal guide catheter to the interventricular septum; and

cutting the suture in the right ventricle adjacent the sealing device.

6. The method of claim 1 , further comprising:

threading a proximal end of the suture through an anchoring device;

advancing the anchoring device through the internal guide catheter to the opening in the interventricular septum; and

positioning the anchoring device with the sealing device within the interventricular septum such that the suture extends between the mitral valve and the opening in the interventricular septum.

7. A method of repairing a mitral valve in a beating heart of a patient comprising:

intravenously accessing a right ventricle of a beating heart of a patient;

creating an opening though an interventricular septum of the patient's heart between the right ventricle and the left ventricle;

positioning a deployment catheter containing a repair device in the left ventricle by extending the deployment catheter through the opening in the interventricular septum;

deploying a suture onto a mitral valve by drawing the suture through a mitral valve leaflet with a needle;

withdrawing the deployment catheter from the left ventricle through the interventricular septum.

8. The method of claim 7 , further comprising:

positioning a sealing device within the opening in the interventricular septum; and

connecting a locking device with the sealing device.

9. The method of claim 7 , further comprising:

positioning a sealing device within the opening in the interventricular septum such that the suture extends from the mitral valve in the left ventricle through the interventricular septum and into the right ventricle.

10. The method of claim 9 , further comprising:

advancing an anchoring device to the interventricular septum; and

locking a position of the suture with respect to the sealing device with the anchoring device.

11. The method of claim 10 , further comprising:

advancing a cutting tool to the interventricular septum; and

cutting the suture in the right ventricle adjacent the sealing device.

12. A method, comprising:

providing a mitral valve repair system, the system including a side exiting external guide catheter, an internal guide catheter, a septal puncture tool and a deployment catheter;

providing instructions for deploying a suture onto a mitral valve of a beating heart of a patient with the mitral valve repair system, the instructions comprising:

inserting the side exiting external guide catheter through a vein of the patient and into a right atrium of the heart of the patient;

advancing the external guide catheter into the right ventricle of the patient's heart;

advancing the internal guide catheter through the external guide catheter and advancing the internal guide catheter into the right ventricle;

directing the septal puncture tool adjacent and generally transversely to the ventricular wall via the side exiting external guide catheter;

puncturing an interventricular septum in the patient's heart with the septal puncture tool to create an opening between the right ventricle and the left ventricle;

advancing the internal guide catheter through the opening in the interventricular septum into the left ventricle;

advancing the deployment catheter through the internal guide catheter and advancing the deployment catheter through the interventricular septum and into the left ventricle; and

deploying a suture onto the mitral valve with the deployment catheter.

13. The method of claim 12 , wherein the mitral valve repair system further includes a sealing device and the instructions further comprise:

advancing the sealing device through the internal guide catheter to the interventricular septum; and

positioning the sealing device within the opening in the interventricular septum.

14. The method of claim 12 , wherein the step of deploying a suture onto the mitral valve with the deployment catheter includes:

capturing a mitral valve leaflet with a clamping mechanism of the deployment catheter; and

inserting the suture through the mitral valve leaflet with a needle of the deployment catheter.

15. The method of claim 12 , wherein the mitral valve repair system further includes a sealing device and the instructions further comprise:

advancing the sealing device through the internal guide catheter to the interventricular septum; and

positioning the sealing device within the opening in the interventricular septum such that a proximal end of the suture extends from the mitral valve through the interventricular septum.

16. The method of claim 15 , wherein the mitral valve repair system further comprises a cutting catheter having a cutting tool and the instructions further comprise:

advancing the cutting catheter and cutting tool through the internal guide catheter to the interventricular septum; and

cutting the suture in the right ventricle adjacent the sealing device.

17. The method of claim 12 , wherein the mitral valve repair system further includes an anchoring device and the instructions further comprise:

threading a proximal end of the suture through the anchoring device;

advancing the anchoring device through the internal guide catheter to the opening in the interventricular septum; and

positioning the anchoring device within the interventricular septum such that the suture extends between the mitral valve and the opening in the interventricular septum.