Process for the production of storable implants with an ultrahydrophilic surface
The present invention concerns a process for the production of implants with an ultrahydrophilic surface as well as the implants produced in that way and also processes for the production of loaded, so-called bioactive implant surfaces of metallic or ceramic materials, which are used for implants such as artificial bones, joints, dental implants or also very small implants, for example what are referred to as stents, as well as implants which are further produced in accordance with the processes and which as so-called “delivery devices” allow controlled liberation, for example by way of dissociation, of the bioactive molecules from the implant materials.
1. A storable implant, comprising:
an implant material having an ultrahydrophilic surface, wherein said implant material is selected from the group consisting of- pure titanium, metallic titanium alloys, chromium/nickel/aluminum/vanadium/cobalt alloys, TiAlV4, TiAlFe 2.5 , steels, V2A, V4A, chromium-nickel 316L, ceramic materials, hydroxyapatite, aluminum oxide, and combinations thereof with ceramic materials,
wherein said ultrahydrophilic surface comprises an oxide layer, and
wherein said ultrahydrophilic surface further comprises a salt layer.
2. The storable implant of claim 1 , wherein the salt layer covers at least the ultrahydrophilic surface and has a layer thickness of 1 to 500 μm.
3. The storable implant of claim 1 , wherein the salt layer encloses the ultrahydrophilic surface on all sides.
4. The storable implant of claim 1 , wherein the ultrahydrophilic surface is sterile.
5. A packaged storable implant, comprising:
an implant material having an ultrahydrophilic surface, wherein said implant material is selected from the group consisting of- pure titanium, metallic titanium alloys, chromium/nickel/aluminum/vanadium/cobalt alloys, TiAlV4, TiAlFe 2.5 , steels, V2A, V4A, chromium-nickel 316L, ceramic materials, hydroxyapatite, aluminum oxide, and combinations thereof with ceramic materials,
wherein said ultrahydrophilic surface comprises an oxide layer, and
wherein said ultrahydrophilic surface further comprises a salt layer, wherein said ultrahydrophilic surfaces comprises an oxide layer, wherein the implant material is in a transport packaging, wherein said transport packaging is closed in gas-tight and liquid-tight fashion, wherein said transport packaging further comprises a salt-containing aqueous solution which is inert in relation to the ultrahydrophilic surface and which encloses the implant material on all sides, wherein said salt-containing aqueous solution has a total ion concentration of more than 0.5mol/L.
6. The packaged storable implant of claim 5 , wherein the salt-containing aqueous solution has a total ion concentration of more than 1 mol/L.
7. The packaged storable implant of claim 5 , wherein the ultrahydrophilic surface is sterile.