METHOD FOR INHIBITING CELL GROWTH USING ANTI-ERBB-3 ANTIBODIES
Methods for arresting or inhibiting cell growth, particularly cancer cell growth, comprising preventing or reducing ErB-2/ErbB-3 heterodimer formation, or interfering with ErB-2/ErbB-3 heterodimer conformation in a cell and agents which prevent or reduce ErB-2/ErbB-3 heterodimer formation or interface with ErB-2/ErbB-3 heterodimer conformation in a cell thereby arresting or inhibiting the growth of the cell.
1 - 26 . (canceled)
27 . A method of arresting or inhibiting cell growth comprising contacting an ErbB-2 over-expressing cell with an anti-ErbB-3 antibody, thereby arresting or inhibiting growth of said ErbB-2 over-expressing cell.
28 . The method of claim 27 , wherein the anti-ErbB-3 antibody is H3.105.5.
29 . The method of claim 27 , wherein the anti-ErbB-3 antibody is a monoclonal antibody.
30 . The method of claim 29 , wherein the monoclonal antibody is humanized.
31 . The method of claim 27 , wherein the cell is a cancer cell.
32 . The method of claim 31 , wherein the cancer cell is a human breast cancer cell.
33 . The method of claim 32 , wherein the human breast cancer cell is SK-BR-3, MDA-MB-453, or BT-474.
34 . A method for treating ErbB-2 over-expressing cancer, comprising administering to a subject in need thereof a composition comprising an anti-ErbB-3 antibody, thereby treating ErbB-2 over-expressing cancer in said subject.
35 . The method of claim 34 , wherein the anti-ErbB-3 antibody is H3.105.5.
36 . The method of claim 34 , wherein the anti-ErbB-3 antibody is a monoclonal antibody.
37 . The method of claim 36 , wherein the monoclonal antibody is humanized.
38 . The method of claim 34 , wherein the cancer is a human breast cancer.