Automatic analyzer and sample-processing system
View Patent ↗A sample-processing system that improves total system processing efficiency, and reduces a sample-processing time, by establishing a functionally independent relationship between a rack conveyance block with rack supply, conveyance, and recovery functions, and a processing block with sample preprocessing, analysis, and other functions. A buffer unit with random accessibility to multiple racks standing by for processing is combined with each of multiple processing units to form a pair, and the system is constructed to load and unload racks into and from the buffer unit through the rack conveyance block so that one unprocessed rack is loaded into the buffer unit and then upon completion of process steps up to automatic retesting, unloaded from the buffer unit. Functional dependence between any processing unit and a conveyance unit is thus eliminated.
1. A sample processing system comprising:
a plurality of functional modules arranged along an X-direction;
a loader for loading a plurality of sample racks;
a pipette included in each functional module configured to pipette a sample held in a sample rack;
a plurality of second buffer units each combined with a functional module in a one-to-one correspondence to form a pair;
a conveyance unit extending in the X-direction, and connected to each second buffer unit, for conveying sample racks loaded by the loader to each of the plurality of functional modules through each of the plurality of second buffer units;
a first internal buffer unit included in each of the functional modules configured to temporarily hold a sample rack at a buffer position in the first internal buffer unit while the temporarily held sample rack awaits a pipetting process by the pipette of the respective functional module at a pipetting position in the first internal buffer unit of each functional module;
a plurality of independent conveyance lines each extending in the X-direction, each connecting respective second buffer units to respective paired functional modules and each extending from the respective second buffer units into the respectively paired functional modules, wherein each conveyance line is independent of the conveyance unit and each conveyance line is configured to convey a sample rack from each respective second buffer unit to each first internal buffer of each respectively paired functional module; and
a control unit,
wherein each first internal buffer unit in each respective functional module is configured to receive sample racks from the conveyance unit and from the each respective second buffer unit of the respectively paired functional module, where the sample racks move from the conveyance unit through each respective second buffer unit and each respective conveyance line to each respective first internal buffer unit,
wherein each second buffer unit is disposed along a Y-direction relative to the conveyance unit conveying the sample racks in the X-direction,
wherein each second buffer unit has a plurality of slots and each slot is configured to hold a sample rack temporarily,
wherein each second buffer unit is disposed closer to the loader than the first internal buffer unit of the paired functional module,
wherein the control unit is programmed to:
execute the pipetting process by controlling each pipette to pipette a sample at each respective pipetting position in each first internal buffer unit from a sample rack that has been temporarily held in each respective first internal buffer unit at the respective buffer positions in each first internal buffer unit.
2. The sample processing system according to claim 1 , further comprising:
a rack unloading mechanism included in each second buffer unit,
the control unit is further programmed to:
continually control each rack unloading mechanism to move a sample rack to the conveyance line of each paired functional module from each respective second buffer unit until the control unit determines that the first internal buffer unit cannot accept any more sample racks, and if the control unit determines that the first internal buffer cannot accept any more sample racks, control each rack unloading mechanism to temporarily hold sample racks in the respective second buffer units.
3. The sample processing system according to claim 1 , wherein
the control unit is further programmed to:
determine whether a sample rack from the conveyance unit is moved to a second buffer unit or to a first internal buffer unit.
4. The sample processing system according to claim 1 , further comprising:
a rack transfer mechanism included in each second buffer unit,
wherein the control unit is further programmed to:
control the rack transfer mechanism to, in the second buffer unit, lift a sample rack in a Z-direction, and move a sample rack in the Y-direction.
5. The sample processing system according to claim 1 , wherein
the first internal buffer unit holds the plurality of sample racks in a series.
6. The sample processing system according to claim 1 , further comprising:
a plurality of rack unloading mechanisms, each in a respective second buffer unit, each configured to move a sample rack from a slot of each of the second buffer units to a standby position on each respective conveyance line,
wherein the control unit is further programmed to control each rack unloading mechanism to move a sample rack held in a slot of each of the second buffer units to a standby position on each respective conveyance line without being moved onto the conveyance unit.
7. A sample processing system comprising:
a plurality of functional modules arranged along a first direction;
a loader for loading a plurality of sample racks;
a pipette included in each functional module configured to pipette a sample held in a sample rack;
a plurality of second buffer units each combined with a functional module in a one-to-one correspondence to form a pair;
a conveyance unit extending in the first direction, and connected to each second buffer unit, for conveying sample racks loaded by the loader to each of the plurality of functional modules through each of the plurality of second buffer units;
a first internal buffer unit included in each of the functional modules configured to temporarily hold a sample rack at a buffer position in the first internal buffer unit while the temporarily held sample rack awaits a pipetting process by the pipette of the respective functional module at a pipetting position in the first internal buffer unit of each functional module;
a plurality of independent conveyance lines each extending in the first direction, each connecting respective second buffer units to respective paired functional modules and each extending from the respective second buffer units into the respectively paired functional modules, wherein each conveyance line is independent of the conveyance unit and each conveyance line is configured to convey a sample rack from each respective second buffer unit to each first internal buffer of each respectively paired functional module; and
a control unit,
wherein each first internal buffer unit in each respective functional module is configured to receive sample racks from the conveyance unit and from the each respective second buffer unit of the respectively paired functional module, where the sample racks move from the conveyance unit through each respective second buffer unit and each respective conveyance line to each respective first internal buffer unit,
wherein each second buffer unit is disposed in a second direction, different from the first direction,
wherein each second buffer unit has a plurality of slots and each slot is configured to hold a sample rack temporarily,
wherein each second buffer unit is disposed closer to the loader than the first internal buffer unit of the paired functional module,
wherein the control unit is programmed to:
execute the pipetting process by controlling each pipette to pipette a sample at each respective pipetting position in each first internal buffer unit from a sample rack that has been temporarily held in each respective first internal buffer unit at the respective buffer positions in each first internal buffer unit.
8. The sample processing system according to claim 7 ,
the further comprising:
a rack unloading mechanism included in each second buffer unit,
the control unit is further programmed to:
continually control rack unloading mechanism to move a sample rack to the conveyance line of each paired functional module from each respective second buffer unit until the control unit determines that the first internal buffer unit cannot accept any more sample racks, and if the control unit determines that the first internal buffer cannot accept any more sample racks, control each rack unloading mechanism to temporarily hold sample racks in the respective second buffer units.
9. The sample processing system according to claim 7 , wherein
the control unit is further programmed to:
determine whether a sample rack from the conveyance unit is moved to a first internal buffer unit or a second buffer unit.
10. The sample processing system according to claim 7 ,
further comprising a rack moving mechanism included in each second buffer unit,
the control unit is further programmed to:
control the rack moving mechanism to move a sample rack not processed by the pipetting process and a sample rack that has finished the pipetting process and to be processed again by the pipetting process to a slot of the second buffer unit.
11. The sample processing system according to claim 7 , further comprising:
a rack transfer mechanism included in each second buffer unit,
wherein the control unit is further programmed to:
control each rack transfer mechanism to, in each second buffer unit, lift a sample rack in an upwards direction, and move a sample rack in the second direction.
12. The sample processing system according to claim 7 , wherein
the first internal buffer unit holds the plurality of sample racks in a series.
13. The sample processing system according to claim 7 ,
further comprising:
a plurality of rack unloading mechanisms, each in a respective second buffer unit, each configured to move a sample rack from a slot of each of the second buffer units to a standby position on each respective conveyance line,
wherein the control unit is further programmed to control each rack unloading mechanism to move a sample rack held in a slot of each of the second buffer units to a standby position on each respective conveyance line without being moved onto the conveyance unit.
14. A sample processing system comprising:
a plurality of functional modules;
a loader for loading a plurality of sample racks;
a pipette included in each functional module configured to pipette a sample held in a sample rack;
a plurality of second buffer units each combined with a functional module in a one-to-one correspondence to form a pair;
a conveyance unit extending along the functional modules, and connected to each second buffer unit, for conveying sample racks loaded by the loader to each of the plurality of functional modules through each of the plurality of second buffer units;
a first internal buffer unit included in the functional modules configured to accept and temporarily hold a sample rack at a buffer position in the first internal buffer while the temporarily held sample rack awaits pipetting process by the pipette of the respective functional module at a pipetting position in the first internal buffer unit of each functional module;
a plurality of independent conveyance lines each connecting respective second buffer units to respective paired functional modules and each extending from the respective second buffer units into the respectively paired functional modules, wherein each conveyance line is independent of the conveyance unit and each conveyance line is configured to convey a sample rack from each respective second buffer unit to each first internal buffer of each respectively paired functional module; and
a control unit,
wherein each first internal buffer unit in each respective functional module is configured to receive sample racks from the conveyance unit and from the each respective second buffer unit of the respectively paired functional module, where the sample racks move from the conveyance unit through each respective second buffer unit and each respective conveyance line to each respective first internal buffer unit,
wherein each second buffer unit has a plurality of slots and each slot is configured to hold a sample rack temporarily,
wherein each second buffer unit is disposed closer to the loader than the first internal buffer unit of the paired functional module ,
wherein the control unit is programmed to:
execute the pipetting process by controlling each pipette to pipette a sample at each respective pipetting position in each first internal buffer unit from a sample rack that has been temporarily held in each respective first internal buffer unit at the respective buffer positions in each first internal buffer unit.
15. The sample processing system according to claim 14 , further comprising:
a plurality of rack unloading mechanisms, each in a respective second buffer unit, each configured to move a sample rack from a slot of each of the second buffer units to a standby position each respective conveyance line,
wherein the control unit is further programmed to control each rack unloading mechanism to move a sample rack held in a slot of each of the second buffer units to a standby position on each respective conveyance line without being moved onto the conveyance unit.