Method for treatment of diseases
The invention provides a method of inhibiting vascular hyperpermeability in an animal in need thereof. The method comprises administering a vascular-hyperpermeability-inhibiting amount of a danazol compound to the animal. The invention also provides a method of modulating the cytoskeleton of an endothelial cell in an animal. The method comprises administering an effective amount of a danazol compound to the animal.
1. A method of reducing symptoms, duration and/or severity of vasogenic cerebral edema in a human comprising orally administering to the human a vascular-hyperpermeability-inhibiting amount of danazol or pharmaceutically-acceptable salts of danazol, wherein the hyperpermeability-inhibiting amount is from 1 mg to 100 mg per day.
2. The method of claim 1 wherein the administration of danazol is commenced immediately upon diagnosis of the vasogenic cerebral edema.
3. The method of claim 1 wherein the vascular hyperpermeability is vascular hyperpermeability of a continuous endothelium found in, or around, a brain.
4. The method of claim 1 wherein the vascular-hyperpermeability-inhibiting amount is from 10 mg to 90 mg of the danazol compound per day.