Systems, Methods, and Compositions For Cross-Linking Treatments of an Eye
Systems, methods, and compositions generate cross-linking activity for treatment of eye disorders. Various agents, additives, buffers, etc., may be employed in formulations with a cross-linking agent to enhance treatment. For example, a composition for applying treatment to a cornea of an eye includes a cross-linking agent that generates cross-linking activity in the cornea in response to exposure to a photo-activating light. The composition also includes an iron additive and citrate buffer. In some cases, the cross-linking agent may include riboflavin. In other cases, the iron additive may include FeSO 4 . In further cases, the iron additive may be dissolved in the citrate buffer.
1 . A composition for applying treatment to a cornea of an eye, comprising:
a cross-linking agent that generates cross-linking activity in the cornea in response to exposure to a photo-activating light;
an iron additive; and
citrate buffer.
2 . The composition of claim 1 , wherein the cross-linking agent includes riboflavin.
3 . The composition of claim 1 , wherein the iron additive includes FeSO 4 .
4 . The composition of claim 1 , wherein the iron additive is dissolved in the citrate buffer.
5 . The composition of claim 1 , wherein the photo-activating light is ultraviolet light.
6 . A method for applying treatment to a cornea of an eye, comprising:
applying a composition to the cornea, the composition including:
a cross-linking agent that generates cross-linking activity in the cornea in response to exposure to a photo-activating light;
an iron additive; and
citrate buffer;
applying photo-activating light to the cornea to generate cross-linking activity in the cornea.
7 . The method of claim 6 , wherein the cross-linking agent includes riboflavin.
8 . The method of claim 6 , wherein the iron additive includes FeSO 4 .
9 . The method of claim 6 , wherein the iron additive is dissolved in the citrate buffer.
10 . The method of claim 6 , wherein the photo-activating light is ultraviolet light.
11 . The method of claim 6 , wherein the photo-activating light is pulsed.
12 . The method of claim 6 , wherein the photo-activating light is continuous.
13 . The method of claim 6 , further comprising applying a selected concentration of oxygen to the eye, the selected concentration being greater than a concentration of oxygen in atmosphere.