PYRIMIDINE HYDROXY AMIDE COMPOUNDS FOR TREATING PERIPHERAL NEUROPATHY
The invention relates to HDAC inhibitors for the treatment of peripheral neuropathy in a subject in need thereof. Also provided herein are methods for treating peripheral neuropathy in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an HDAC inhibitor.
1 . A method of treating a peripheral neuropathy in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a compound of Formula (I):
or a pharmaceutically acceptable salt thereof,
wherein,
R x and R y together with the carbon to which each is attached, form a cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, or cyclooctyl;
each R A is independently C 1-6 -alkyl, C 1-6 -alkoxy, halo, OH or haloalkyl; and
m is 0, 1, or 2.
or a pharmaceutically acceptable salt thereof, to thereby treat or prevent the peripheral neuropathy.
2 . The method of claim 1 , wherein the peripheral neuropathy is Charcot-Marie Tooth Disease.
3 . The method of claim 1 , wherein the peripheral neuropathy is chemotherapy-induced peripheral neuropathy.
4 . The method of claim 3 , wherein the chemotherapy-induced peripheral neuropathy is taxol-induced peripheral neuropathy or vincristine-induced peripheral neuropathy.
5 . A method of treating a peripheral neuropathy in a subject in need thereof comprising administering to the subject a therapeutically effective amount of the compound:
or a pharmaceutical acceptable salt thereof, to thereby treat or prevent the peripheral neuropathy.
6 . The method of claim 5 , wherein the peripheral neuropathy is Charcot-Marie Tooth Disease.
7 . The method of claim 5 , wherein the peripheral neuropathy is chemotherapy-induced peripheral neuropathy.
8 . The method of claim 7 , wherein the chemotherapy-induced peripheral neuropathy is taxol-induced peripheral neuropathy or vincristine-induced peripheral neuropathy.
9 . A method of treating a peripheral neuropathy in a subject in need thereof comprising administering to the subject a therapeutically effective amount of the compound:
or a pharmaceutical acceptable salt thereof, to thereby treat or prevent the peripheral neuropathy.
10 . The method of claim 9 , wherein the peripheral neuropathy is Charcot-Marie Tooth Disease.
11 . The method of claim 9 , wherein the peripheral neuropathy is chemotherapy-induced peripheral neuropathy.
12 . The method of claim 11 , wherein the chemotherapy-induced peripheral neuropathy is taxol-induced peripheral neuropathy or vincristine-induced peripheral neuropathy.
13 . The method of claim 1 , wherein the subject is a human.