Methods and compositions for treating trinucleotide repeat disorders

1. A cell comprising a complex of a non-naturally occurring zinc finger protein transcription factor and a target site in an Htt gene, wherein the zinc finger protein transcription factor comprises a transcriptional repression domain and a finger protein comprising 5 or 6 zinc finger recognition regions, ordered F1 to F5 or F1 to F6 from N-terminus to C-terminus, wherein the zinc finger protein comprises the recognition helix regions in the order shown in a single row of Table 1 bound to the target site in the Htt gene, the target site comprising sequences as set forth in any of SEQ ID NO:20-23 and 36-39 and further wherein Htt gene expression is repressed in the cell.

2. The cell of claim 1 , wherein the Htt gene is wild-type.

3. The cell of claim 2 , wherein the zinc finger protein binds to a SNP associated with a wild-type allele.

4. The cell of claim 1 , wherein the Htt gene comprises one or more expanded trinucleotide repeats.

5. The cell of claim 4 , wherein the expanded trinucleotide repeat encodes poly-glutamine.

6. The cell of claim 4 , wherein the expanded trinucleotide repeat encodes poly-serine.

7. The cell of claim 4 , wherein the zinc finger protein binds to a SNP associated with the expanded trinucleotide repeat.

8. The cell of claim 1 , wherein the cell comprises a multimer of the zinc finger protein transcription factors and wherein the multimer preferentially binds to expanded trinucleotide tracts as compared to wild-type trinucleotide repeat tracts.