Spray dried human plasma

1. A method for spray-drying plasma, the method comprising:

providing plasma having a protein concentration and derived from human blood to a spray-drying apparatus;

spray-drying, at the spray-drying apparatus, the plasma to form physiologically-active plasma powder, the spray-drying apparatus configured utilizing one or more parameters dependent on the protein concentration of the plasma, wherein the one or more parameters comprise an inlet temperature of substantially between 100° to 114° C., a pump setting of substantially between 18 to 28%, an aspiration setting of substantially between 80% to 100%, a spray flow rate of substantially between 30 to 40 mm Hg, an outlet temperature of substantially between 40° to 44° C., or any combination thereof;

storing the physiologically-active plasma powder for a storage time; and

reconstituting the physiologically-active plasma powder utilizing a reconstitution fluid to form physiologically-active reconstituted plasma.

2. The method of claim 1 , wherein the one or more parameters comprise an inlet temperature of substantially 107° C., a pump setting of substantially 24%, an aspiration setting of substantially 100%, a spray flow rate of substantially 35 mm Hg, an outlet temperature of substantially between 40° to 44° C., or any combination thereof.

3. The method of claim 2 , wherein the spray flow rate is nitrogen flow rate.

4. The method of claim 1 , further comprising applying the physiologically-active reconstituted plasma to a human.

5. The method of claim 1 , wherein a recovery rate of proteins of the physiologically-active reconstituted plasma is at least 90%.

6. The method of claim 1 , wherein the reconstitution fluid comprises distilled water, glycine, or any combination thereof.

7. The method of claim 1 , further comprising:

determining a spray-drying apparatus outlet temperature of the physiologically-active plasma powder; and

adjusting a spray-drying apparatus pump setting and/or a spray-drying apparatus inlet temperature based on the spray-drying apparatus outlet temperature.

8. The method of claim 7 , wherein the adjusting of the spray-drying apparatus pump setting and/or the spray-drying apparatus inlet temperature based on the spray-drying apparatus outlet temperature further comprises adjusting the spray-drying apparatus pump setting and/or the spray-drying inlet temperature if the spray-drying apparatus outlet temperature is not between substantially 40° to 44° C.

9. A spray-dried physiologically-active plasma prepared by:

providing plasma having a protein concentration derived from blood to a spray-drying apparatus;

spray-drying, at the spray-drying apparatus, the plasma to form a physiologically-active plasma powder, the spray-drying apparatus configured utilizing one or more parameters dependent on the protein concentration of the plasma, wherein the one or more parameters comprise an inlet temperature of substantially between 100° to 114° C., a pump setting of substantially between 18 to 28%, an aspiration setting of substantially between 80% to 100%, a spray flow rate of substantially between 30 to 40 mm Hg, an outlet temperature of substantially between 40° to 44° C., or any combination thereof; and

reconstituting the physiologically-active plasma powder utilizing a reconstitution fluid to form physiologically-active reconstituted plasma.

10. The spray-dried physiologically-active plasma of claim 9 , wherein the one or more parameters comprise an inlet temperature of substantially 107° C., a pump setting of substantially 24%, an aspiration setting of substantially 100%, a spray flow rate of substantially 35 mm Hg, an outlet temperature of substantially between 40° to 44° C., or any combination thereof.

11. The spray-dried physiologically-active plasma of claim 10 , wherein the spray flow rate is nitrogen flow rate.

12. A method for spray-drying plasma, the method comprising:

providing plasma having a protein concentration and derived from human blood to a spray-drying apparatus;

spray-drying, at the spray-drying apparatus, the plasma to form physiologically-active plasma powder, the spray-drying apparatus configured utilizing one or more parameters dependent on the protein concentration of the plasma;

determining a spray-drying apparatus outlet temperature of the physiologically-active plasma powder;

adjusting a spray-drying apparatus pump setting and/or a spray-drying apparatus inlet temperature based on the spray-drying apparatus outlet temperature, wherein the adjusting of the spray-drying apparatus pump setting and/or the spray-drying apparatus inlet temperature based on the spray-drying apparatus outlet temperature further comprises adjusting the spray-drying apparatus pump setting and/or the spray-drying inlet temperature if the spray-drying apparatus outlet temperature is not between substantially 40° to 44° C.

storing the physiologically-active plasma powder for a storage time; and

reconstituting the physiologically-active plasma powder utilizing a reconstitution fluid to form physiologically-active reconstituted plasma.

13. A method for spray-drying plasma, the method comprising:

providing plasma having a protein concentration and derived from human blood to a spray-drying apparatus;

spray-drying, at the spray-drying apparatus, the plasma to form physiologically-active plasma powder, the spray-drying apparatus configured utilizing one or more parameters dependent on the protein concentration of the plasma, wherein the one or more parameters comprise an inlet temperature of substantially between 100° to 114° C., a pump setting of substantially between 18 to 28%, an aspiration setting of substantially between 80% to 100%, a spray flow rate of substantially between 30 to 40 mm Hg, an outlet temperature of substantially between 40° to 44° C., or any combination thereof;

storing the physiologically-active plasma powder for a storage time; and

applying the physiologically-active plasma powder directly to a human via application of the physiologically-active plasma powder directly to a wound on the human.