IP Library Granted Patent US 9,821,006
Granted Patent B2
US 9,821,006 · App. 14/989,714 · Granted Nov 21, 2017

Method of producing physiological and therapeutic levels of nitric oxide through an oral delivery system

Inventors: Nathan S. Bryan (Rockdale, TX); Jose G. Rocca (Doral, FL)
Assignees: Board of Regents of the University of Texas System; Neogenis Labs, Inc.
A61K33/00A61K9/0053A61K9/0056A61K9/20A61K9/2009A61K9/2013A61K31/195A61K31/198A61K31/375A61K31/714A61K36/21A61K36/734A61K38/44A61K45/06C12Y107/02001
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Quick Facts
Patent No.
US 9,821,006
App. No.
14/989,714
Granted
Nov 21, 2017
Kind
B2
Abstract

A composition and method of providing nitric oxide and nitrite therapy to patients whereby a therapeutic amount is bioavailable within approximately 30 minutes of administration. In embodiments of the invention, nitric oxide is produced in the oral cavity.

Claims (10)

1. A method of increasing levels of nitric oxide in an individual, comprising the step of orally delivering a therapeutically effective amount of a composition to the individual, wherein the composition comprises:

at least one nitric oxide-producing component; and

a dispersible medium adapted to be consumed in the oral cavity;

wherein the nitric oxide-producing component is adapted to generate nitric oxide in vivo upon consumption of the dispersible medium, and wherein the composition comprises about 1 mg to about 150 mg of a nitrite salt and about 10 mg to about 10,000 mg of nitrite reductase and wherein the composition comprises about 1,000 mg to about 10,000 mg of beet root in powder form.

2. The method of claim 1 , wherein the composition comprises about 10 mg to 500 mg of nitrate.

3. A method of enhancing cardiovascular performance in an individual, comprising the step of orally administering a composition to the individual, wherein the composition comprises:

at least one nitric oxide-producing component; and

a dispersible medium adapted to be consumed in the oral cavity;

wherein the nitric oxide-producing component is adapted to generate nitric oxide in vivo upon consumption of the dispersible medium, and wherein the composition comprises about 1 mg to about 150 mg of a nitrite salt and about 10 mg to about 10,000 mg of nitrite reductase and wherein the composition comprises about 1,000 mg to about 10,000 mg of beet root in powder form.

4. The method of claim 3 , wherein the composition comprises about 10 mg to 500 mg of nitrate.

Assignments (5)
CORRECTIVE ASSIGNMENT TO CORRECT THE THE ASSIGNEE NAME PREVIOUSLY RECORDED AT REEL: 043893 FRAME: 0890. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Jun 9, 2022
From: ROCCA, JOSE G.
To: NEOGENIS LABORATORIES, INC.
Reel/Frame 060328/0535 →
CHANGE OF NAME Recorded Jun 9, 2022
From: NEOGENIS LABORATORIES, INC.
To: HUMAN POWER OF N COMPANY
Reel/Frame 060329/0196 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 18, 2017
From: BRYAN, NATHAN S.
To: NEOGENIS LABS, INC.
Reel/Frame 043892/0850 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 18, 2017
From: BRYAN, NATHAN S.
To: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
Reel/Frame 043893/0753 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 18, 2017
From: ROCCA, JOSE G.
To: NEOGENIS LABS, INC.
Reel/Frame 043893/0890 →
Continuity (4)
Continuation 13588211 · Aug 17, 2012
Continuation In Part 12484364 · Jun 15, 2009
Provisional Application 61524539 · Aug 17, 2011
Related Publication 20160287628A1 · Oct 6, 2016