IP Library Granted Patent US 9,512,138
Granted Patent B2
US 9,512,138 · App. 14/990,651 · Granted Dec 6, 2016

Compositions and methods for treating cancer

Inventors: Richard J. Pietras (Sherman Oaks, CA); Michael E. Jung (Los Angeles, CA); Diana C. Márquez-Garbán (Los Angeles, CA); Gang Deng (Los Angeles, CA)
Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
C07D493/04A61K31/365A61K31/443A61K31/4525A61K45/06
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Quick Facts
Patent No.
US 9,512,138
App. No.
14/990,651
Granted
Dec 6, 2016
Kind
B2
Abstract

Provided herein, inter alia, are compositions and methods useful for treating hyperproliferative diseases, including cancer and non-malignant hyperproliferative diseases.

Claims (8)

1. A compound, or a pharmaceutically acceptable salt thereof, wherein the compound has the formula:

wherein

R 1 and R 2 are independently unsubstituted alkyl, unsubstituted cycloalkyl;

where R 1 and R 2 may optionally be joined to form an unsubstituted heterocycloalkyl.

2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 and R 2 are joined to form an unsubstituted heterocycloalkyl.

3. The compound, or a pharmaceutically acceptable salt thereof, of claim 1 , wherein the compound is

4. A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of one of claims 1 , 2 , or 3 .

5. A pharmaceutical composition comprising a pharmaceutically acceptable excipient; a compound of one of claim 1 , 2 , or 3 ; and an anti-cancer agent.

Assignments (2)
CONFIRMATORY LICENSE Recorded Nov 18, 2019
From: UNIVERSITY OF CALIFORNIA LOS ANGELES
To: THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE ARMY
Reel/Frame 051043/0917 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 8, 2016
From: JUNG, MICHAEL E.; DENG, GANG; PIETRAS, RICHARD J; MARQUEZ-GARBAN, DIANA C
To: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Reel/Frame 037926/0304 →
Continuity (4)
Continuation 14505288 · Oct 2, 2014
Continuation PCTUS2013035010 · Apr 2, 2013
Provisional Application 61619289 · Apr 2, 2012
Related Publication 20160137662A1 · May 19, 2016