Compositions and methods of treating microbes
Disclosed herein are compositions and methods to treat microbial infections and heal wounds. In some embodiments, the microbial infection may be a microbial biofilm. In some embodiments, the composition of the invention may include at least one surface active agent. The surface active agents may be anionic, cationic or non-ionic, or any combination thereof.
1. A composition for treating a microbial infection consisting essentially of:
a poloxamer at a concentration ranging from about 45 to about 55% w/w, the poloxamer consisting essentially of poloxamer 127, poloxamer 188, poloxamer 237, poloxamer 335, poloxamer 407 and combinations thereof,
glycerin at a concentration ranging from about 1 to about 3% w/w,
a preservative at a concentration ranging from about 0.1 to about 2% w/w,
a pH adjuster, and
water.
2. The composition according to claim 1 , the preservative is phenoxyethanol.
3. The composition according to claim 2 , the pH adjuster having at least one of citric acid and sodium phosphate dibasic.
4. The composition according to claim 3 , the pH adjuster having citric acid and sodium phosphate dibasic.
5. The composition according to claim 2 , the poloxamer is poloxamer 188.
6. The composition according to claim 5 , the preservative is phenoxyethanol.
7. The composition according to claim 6 , the pH adjuster having at least one of citric acid and sodium phosphate dibasic.
8. The composition according to claim 7 , the pH adjuster having citric acid and sodium phosphate dibasic.
9. A composition for treating a microbial infection consisting essentially of:
a poloxamer at a concentration ranging from about 45 to about 55% w/w, the poloxamer consisting essentially of poloxamer 127, poloxamer 188, poloxamer 237, poloxamer 335, poloxamer 407 and combinations thereof,
a preservative at a concentration ranging from about 0.1 to about 2% w/w,
a pH adjuster, and
water.
10. The composition according to claim 9 , the preservative is phenoxyethanol.
11. The composition according to claim 9 , the pH adjuster having at least one of citric acid and sodium phosphate dibasic.
12. The composition according to claim 11 , the pH adjuster having citric acid and sodium phosphate dibasic.
13. The composition according to claim 9 , the poloxamer is poloxamer 188.
14. The composition according to claim 13 , the preservative is phenoxyethanol.
15. The composition according to claim 14 , the pH adjuster having at least one of citric acid and sodium phosphate dibasic.
16. The composition according to claim 15 , the pH adjuster having citric acid and sodium phosphate dibasic.
17. A composition for treating a microbial infection consisting essentially of:
a poloxamer at a concentration ranging from about 45 to about 55% w/w, the poloxamer consisting essentially of poloxamer 127, poloxamer 188, poloxamer 237, poloxamer 335, poloxamer 407 and combinations thereof,
glycerin at a concentration ranging from about 1 to about 3% w/w,
a preservative;
a pH adjuster;
a saccharide; and
water.
18. The composition according to claim 17 , the preservative is phenoxyethanol.
19. The composition according to claim 17 , the pH adjuster having at least one of citric acid and sodium phosphate dibasic.
20. The composition according to claim 19 , the pH adjuster having citric acid and sodium phosphate dibasic.
21. The composition according to claim 17 , the poloxamer is poloxamer 188.
22. The composition according to claim 21 , the preservative is phenoxyethanol.
23. The composition according to claim 22 , the pH adjuster having at least one of citric acid and sodium phosphate dibasic.
24. The composition according to claim 23 , the pH adjuster having citric acid and sodium phosphate dibasic.
25. The composition according to claim 24 , the saccharide is sugar.
26. The composition according to claim 17 , the saccharide is dextrose.