System and method for measuring biological fluid biomarkers

1. A cloud-based system for analyzing sweat from a human and transmitting and storing sweat data from the human comprising:

an apparatus for sensing and analyzing sweat, wherein the apparatus includes an electronic layer comprising at least one electrochemical sensor, a microcontroller, and a transceiver antenna coil;

at least one remote transceiver device; and

at least one remote computer server;

wherein the apparatus analyzes at least one sweat biomarker, calculates at least one output datum of the at least one sweat biomarker using at least one algorithm, and transmits the at least one output datum to the at least one remote transceiver device;

wherein the at least one algorithm calculates the at least one output datum using an estimated body surface area of a human and input data, wherein the input data includes at least a height and a weight of the human, and wherein the height and the weight of the human are used to estimate the estimated body surface area of the human;

wherein the at least one remote transceiver device transmits the at least one output datum to the at least one remote computer server for storage in a cloud database and/or processing;

wherein the apparatus and the at least one remote transceiver device have real-time or near-real-time two-way communication; and

wherein the apparatus is flexible and further includes:

a macrofluidic, double-sided adhesive layer;

a microfluidic management layer; and

a vapor porous, top protective layer;

wherein the macrofluidic, double-sided adhesive layer is intimately adhered to an exterior layer of human skin;

wherein the microfluidic management layer is positioned between the macrofluidic, double-sided adhesive layer and the electronic layer;

wherein the microfluidic management layer circumferentially surrounds the at least one electrochemical sensor of the electronic layer;

wherein the at least one electrochemical sensor of the electronic layer is facing the exterior layer of human skin;

wherein the electronic layer is intimately adhered to the macrofluidic, double-sided adhesive layer;

wherein the vapor porous, top protective layer is placed on and completely covers the microfluidic management layer and the electronic layer; and

wherein the vapor porous, top protective layer is intimately adhered to the macrofluidic, double-sided adhesive layer.

2. The system of claim 1 , wherein the at least one sweat biomarker includes small molecules, proteins, metabolites, and/or electrolytes.

3. The system of claim 1 , wherein the microcontroller receiver multiple input data, which are input from multiple sources including the sweat.

4. The system of claim 1 , wherein the at least one electrochemical sensor houses at least one standard electrode and at least one active electrode.

5. The system of claim 4 , wherein the at least one standard and/or the at least one active electrode are silver, zinc, copper, gold, platinum, rhodium, carbon, or a combination thereof.

6. The system of claim 1 , wherein the apparatus wirelessly transmits the at least one output datum to the at least one remote transceiver device.

7. The system of claim 6 , wherein the apparatus wirelessly transmits the at least one output datum via Bluetooth, radiofrequency, zigbee, wi-fi, or near field communication.

8. The system of claim 1 , wherein the apparatus continuously monitors the at least one sweat biomarker.

9. The system of claim 1 , wherein the input data further includes gender, fitness or conditioning level, age, and a maximum rate of oxygen consumption for the human (VO2 max).

10. The system of claim 1 , wherein the two-way communication further comprises commands, electrode calibration, microcontroller software updates, new or updated algorithms, new or updated modifying variables for algorithms, microcontroller health properties, error codes, electrode maintenance or malfunction, or a combination thereof.

11. The system of claim 1 , wherein the at least one remote computer server includes a library and wherein the library is operable to perform file storage, security, extensions, utilities, scheduling, messaging, persistence, cache, and logging functions.

12. The system of claim 1 , wherein the at least one remote computer server automatically validates data.

13. The system of claim 1 , wherein the at least one remote computer server triggers a series of workflows based on the type, date/time stamps, and scope of data to correlate and identify trends.

14. The system of claim 1 , further including a mobile application on the at least one remote transceiver device.

15. A cloud-based method for analyzing sweat from a human and transmitting and storing sweat data from the human, the method comprising:

providing an apparatus for sensing and analyzing sweat,

wherein the apparatus includes an electronic layer comprising at least one electrochemical sensor, a microcontroller, and a transceiver antenna coil; at least one remote transceiver device;

and at least one remote computer server;

wherein the at least one remote transceiver device and the apparatus are operable for two-way cross-communication in real-time or near-real-time;

the at least one electrochemical sensor sensing at least one biomarker of the sweat, which creates a voltage;

the microcontroller converting the at least one biomarker of the sweat into at least one output datum using at least one algorithm, wherein the at least one algorithm calculates the at least one output datum using an estimated body surface area of a human and input data, wherein the input data includes at least a height and a weight of the human, and wherein the height and the weight of the human are used to estimate the estimated body surface area of the human;

the at least one remote transceiver device inputting modifying variables into the at least one algorithm via the two-way communication with the apparatus;

the transceiver antenna coil transmitting the at least one output datum to the at least one remote transceiver device via the two-way communication with the apparatus;

the at least one remote transceiver device sharing or transmitting the at least one datum with the at least one remote computer server for storage in a cloud database and/or processing; and

wherein the apparatus is flexible and further includes:

a macrofluidic, double-sided adhesive layer;

a microfluidic management layer; and

a vapor porous, top protective layer;

wherein the macrofluidic, double-sided adhesive layer is intimately adhered to an exterior layer of human skin;

wherein the microfluidic management layer is positioned between the macrofluidic, double-sided adhesive layer and the electronic layer;

wherein the microfluidic management layer circumferentially surrounds the at least one electrochemical sensor of the electronic layer;

wherein the at least one electrochemical sensor of the electronic layer is facing the exterior layer of human skin;

wherein the electronic layer is intimately adhered to the macrofluidic, double-sided adhesive layer;

wherein the vapor porous, top protective layer is placed on and completely covers the microfluidic management layer and the electronic layer; and

wherein the vapor porous, top protective layer is intimately adhered to the macrofluidic, double-sided adhesive layer.

16. The method of claim 15 , wherein the at least one biomarker of the sweat includes small molecules, proteins, metabolites, and/or electrolytes.

17. The method of claim 15 , wherein the at least one output datum includes but is not limited to concentrations, such as molarity, osmolarity, and osmolality, and/or descriptive statistics, such as averages, ratios, and trends, all of which may be categorized based on a sub-range within a larger physiological range of the at least one biomarker.

18. The method of claim 15 , wherein the at least one output datum is transmitted from the apparatus to a remote computer device through wireless network communication by the transceiver antenna of the apparatus.

19. The method of claim 18 , wherein the wireless network communication is via Bluetooth, radiofrequency, zigbee, wi-fi, or near field communication.

20. A cloud-based system for continuously analyzing sweat from a human in real-time and transmitting and storing sweat data from the human comprising:

an apparatus for sensing and analyzing sweat, wherein the apparatus includes an electronic layer comprising at least one electrochemical sensor, a microcontroller, and a transceiver antenna coil;

at least one remote transceiver device; and

at least one remote computer server;

wherein the apparatus continuously analyzes at least one sweat biomarker in real-time, calculates at least one output datum of the at least one sweat biomarker using at least one algorithm, and transmits the at least one output datum to the at least one remote transceiver device;

wherein the at least one algorithm calculates the at least one output datum using an estimated body surface area of a human and input data, wherein the input data includes at least a height and a weight of the human, a maximum rate of oxygen consumption for the human (VO 2 max), and a body mass of the human, and wherein the height and the weight of the human are used to estimate the estimated body surface area of the human;

wherein the at least one remote transceiver device transmits the at least one output datum to the at least one remote computer server for storage in a cloud database and/or processing;

wherein the apparatus and the at least one remote transceiver device have real-time or near-real-time two-way communication;

wherein the electrochemical sensor has at least one reference electrode and at least one active electrode;

wherein the at least one active electrode has an ionophore polymer coating;

wherein the apparatus is flexible and further includes:

a macrofluidic, double-sided adhesive layer;

a microfluidic management layer; and

a vapor porous, top protective layer;

wherein the macrofluidic, double-sided adhesive layer is intimately adhered to an exterior layer of human skin;

wherein the microfluidic management layer is positioned between the macrofluidic, double-sided adhesive layer and the electronic layer;

wherein the microfluidic management layer circumferentially surrounds the at least one electrochemical sensor of the electronic layer;

wherein the at least one electrochemical sensor of the electronic layer is facing the exterior layer of human skin;

wherein the electronic layer is intimately adhered to the macrofluidic, double-sided adhesive layer;

wherein the vapor porous, top protective layer is placed on and completely covers the microfluidic management layer and the electronic layer; and

wherein the vapor porous, top protective layer is intimately adhered to the macrofluidic, double-sided adhesive layer.