Steroids as agonists for FXR
The invention relates to compounds of formula (I): wherein R is ethyl, propyl or allyl, and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof. The compounds of formula (I) are useful as FXR agonists.
1. A pharmaceutically acceptable salt of compound of formula I:
wherein R is ethyl, or amino acid conjugate thereof,
wherein the pharmaceutically acceptable salt can be selected from a group consisting of aluminum salt, calcium salt, lithium salt, magnesium salt, potassium salt, sodium salt, and zinc salt or N, N′-dibenzylethylenediamine salt, chlorprocaine salt, choline salt, diethanolamine salt, ethylendiamine salt, meglumine (N-methylglucamine) salt, and procaine salt.
2. The sodium salt of the compound of claim 1 .
3. The lithium salt of the compound of claim 1 .
4. The potassium salt of the compound of claim 1 .
5. The calcium salt of the compound of claim 1 .
6. The magnesium salt of the compound of claim 1 .
7. The zinc salt of the compound of claim 1 .
8. The choline salt of the compound of claim 1 .
9. The diethanolamine salt of the compound of claim 1 .
10. The N-methylglucamine salt of the compound of claim 1 .