MODULAR SURFACE FUNCTIONALIZATION OF POLYISOBUTYLENE-BASED MATERIALS
A polymer composite includes a functionalized polyisobutylene and an additional polyisobutylene-containing material. One or more methods of making the polymer composite are also provided. Where the functionalized polyisobutylene is applied to a polyisobutylene-containing material, the method of applying the functionalized polyisobutylene compound can be described as a modular method.
1 . A polymer composite comprising a functionalized polyisobutylene and an additional polyisobutylene-containing material.
2 . The composite of claim 1 , wherein said functionalized polyisobutylene and said additional polyisobutylene-containing material are not attached by a covalent bond.
3 . The composite of claim 1 , wherein said additional polyisobutylene-containing material is non-functionalized.
4 . The composite of claim 1 , wherein said functionalized polyisobutylene includes a functional group selected from the group consisting of hydroxyl group, alkyl alcohols, ethylene glycol, oligomers of ethylene glycol, poly(ethylene glycol), poly(ethylene oxide), α-lipoic acid, amino acids, nucleic acids, saccharides, tocopherols, carotenoids, phosphatidylcholine, and combinations thereof.
5 . The composite of claim 1 , wherein the functional group includes a hydroxyl group.
6 . The composite of claim 1 , wherein the functional group includes α-lipoic acid.
7 . The composite of claim 5 , wherein said functionalized polyisobutylene further includes poly(ethylene glycol).
8 . The composite of claim 1 , wherein said additional polyisobutylene-containing material is selected from the group consisting of linear polyisobutylene TPEs, star polyisobutylene TPEs, and arborescent polyisobutylene TPEs.
9 . The composite of claim 1 , wherein said additional polyisobutylene-containing material is selected from the group consisting of linear poly(isobutylene(OH)-b-(isobutylene-co-para-methylstyrene)s, star poly(isobutylene(OH)-b-(isobutylene-co-para-methylstyrene)s, arborescent poly(isobutylene(OH)-b-(isobutylene-co-para-methylstyrene)s, linear poly(styrene-b-isobutylene-b-styrene)s, star poly(styrene-b-isobutylene-b-styrene)s, arborescent poly(styrene-b-isobutylene-b-styrene)s, linear poly(isobutylene-OH-co-para-methylstyrene), star poly(isobutylene-OH-co-para-methylstyrene), arborescent poly(isobutylene-OH-co-para-methylstyrene), linear poly(alloocimene-b-isobutylene-b-alloocimene), star poly(alloocimene-b-isobutylene-b-alloocimene), and arborescent poly(alloocimene-b-isobutylene-b-alloocimene).
10 . The composite of claim 1 , the composite being coated on a substrate.
11 . The composite of claim 10 , wherein said substrate is selected from the group consisting of a breast implant, a stent, a knee implant, a catheter, and a wire.
12 . The composite of claim 10 , wherein said substrate is a biocompatible material.
13 . The composite of claim 10 , wherein the composite has a protein adsorption of less than 50 ng/cm 2 with respect to the protein fibrinogen.
14 . The composite of claim 10 , wherein the composite includes a drug or molecule attached to the surface.
15 . A method for producing the polymer composite of claim 1 , where the additional polyisobutylene-containing material is a substrate having a surface, the method comprising the step of coating the surface of the substrate with the functionalized polyisobutylene.
16 . The method of claim 15 , where the step of coating includes spray coating the functionalized polyisobutylene on to the surface of the substrate.
17 . The method of claim 15 , where the step of coating includes dipping the surface of the substrate in a solution containing the functionalized polyisobutylene.
18 . A method for producing the polymer composite of claim 1 , comprising the steps of
providing a polymer combination comprising the functionalized polyisobutylene and the additional polyisobutylene-containing material, and
depositing the polymer combination on to a substrate.
19 . The method of claim 18 , where the step of depositing is electrospraying.
20 . The method of claim 18 , where the step of depositing is electrospinning.