Deoxynojirimycin derivatives and methods of their using
The present application provide novel iminosugars and their use in treatment of viral infections, such as Dengue infection and Influenza A infection. The present inventors discovered certain deoxynojirimycin derivatives may be effective against one or more viruses, which may be, for example, a Dengue virus and/or a virus belonging to the Orthomyxoviridae family, such as an Influenza A virus. In particular, such deoxynojirimycin derivatives may be useful for treating a disease or condition caused by or associated with one or more viruses. In certain embodiments, the deoxynojirimycin derivatives may increase a survival rate or probability for a subject infected with one or more viruses, which may be, for example, a Dengue virus and/or a virus belonging to the Orthomyxoviridae family, such as an Influenza A virus.
1. A compound having the formula:
or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition comprising a) a pharmaceutically effective amount of the compound according to claim 1 and b) a pharmaceutically acceptable carrier.
3. A method of treating a Dengue viral infection in a subject in need of such treatment comprising administering to the subject an effective amount of a compound having the formula:
or a pharmaceutically acceptable salt thereof.
4. The method of claim 3 , wherein the dengue viral infection is a Dengue 2 viral infection.
5. The method of claim 3 , wherein the subject is a mammal.
6. The method of claim 5 , wherein the subject is a human.
7. A method of treating an influenza viral infection in a subject in need of such treatment, comprising administering to the subject an effective amount of a compound having the formula:
or a pharmaceutically acceptable salt thereof.
8. The method of claim 7 , wherein the virus is an Influenza A virus.
9. The method of claim 8 , wherein the virus is a H3N2 subtype of the Influenza A virus.
10. The method of claim 8 , wherein the virus is a H1N1 subtype of the Influenza A virus.
11. The method of claim 7 , wherein the subject is a mammal.
12. The method of claim 11 , wherein the subject is a human being.