Treatment of inflammatory skin disease
The methods, compositions, and assays described herein are based, in part, on the discovery that CD1a mediates inflammation related to certain conditions such as urushiol exposure, psoriasis and other inflammatory skin diseases. One aspect provided herein relates to a method for treating or preventing an inflammatory skin disease, the method comprising: administering a therapeutically effective amount of an inhibitor of CD 1a to a subject having an inflammatory skin disease, thereby treating or preventing the inflammatory skin diseases.
1. A method for treating inflammatory skin disease, the method comprising: administering a therapeutically effective amount of a monoclonal CD1a antibody or fragment thereof to a subject having uroshiol-induced contact dermatitis, atopic dermatitis or psoriasis,
wherein the CD1a antibody comprises:
(i) a heavy chain complementarity determining region (HCDR) 3 consisting of the amino acid sequence of SEQ ID NO: 1,
(ii) a HCDR2 consisting of the amino acid sequence of SEQ ID NO: 67,
(iii) a HCDR1 consisting of the amino acid sequence of SEQ ID NO: 66,
(iv) a light chain complementarity determining region (LCDR) 1 consisting of the amino acid sequence of SEQ ID NO: 68,
(v) a LCDR2 consisting of the amino acid sequence of SEQ ID NO: 69, and
(vi) a LCDR3 consisting of the amino acid sequence of SEQ ID NO: 70, thereby treating the uroshiol-induced contact dermatitis, atopic dermatitis, or psoriasis.
2. The method of claim 1 , wherein the CD1a antibody is a human or humanized antibody.