Process for preparation of dimethyl fumarate
The present invention relates to a process for the preparation of dimethyl fumarate, a compound of formula I, in a purity of at least 99.0% as determined by HPLC, containing less than 400 ppm of an anion of a mineral acid and less than 5 ppm of dimethyl maleate.
1. A process for the preparation of dimethyl fumarate, a compound of formula I,
in a purity of at least 99.0% as determined by HPLC, containing less than 400 ppm of an anion of a mineral acid and less than 5 ppm of dimethyl maleate and having a D90 particle size of at least 400 μm, the process comprising:
(a) reacting fumaric acid with an acyl halide in methanol to obtain dimethyl fumarate, a compound of formula I, wherein a molar equivalent of the acyl halide is in the range of from about an equimolar amount to about 2 times the molar amount with respect to fumaric acid;
(b) subjecting dimethyl fumarate, the compound of formula I, to treatment with a base; and
(c) isolating dimethyl fumarate, the compound of formula I, from crystallization in a solvent, in a purity of at least 99.0% as determined by HPLC, containing less than 400 ppm of an anion of a mineral acid and less than 5 ppm of dimethyl maleate and having a D90 particle size of at least 400 μm.
2. The process of claim 1 , wherein the anion of a mineral acid is selected from the group consisting of chloride, bromide, iodide, fluoride, sulphate, nitrate and phosphate.
3. The process of claim 1 , wherein the isolated dimethyl fumarate, a compound of formula I, is free of dimethyl sulfate.
4. The process of claim 1 , wherein the isolated dimethyl fumarate is free of dimethyl sulfate and has a monomethyl fumarate content of less than 0.15%.
5. The process of claim 1 , wherein the solvent in step (c) is selected from the group consisting of an alcohol, an ester, a ketone, an ether, a haloalkane, acetonitrile; dimethyl sulfoxide; dimethyl formamide; dimethyl acetamide; water and mixtures thereof.
6. The process of claim 1 , wherein the solvent in step (c) is methanol.
7. The process of claim 1 , wherein the isolated dimethyl fumarate obtained in step (c) has a D90 particle size of 400 to 600 μm.
8. The process of claim 6 , wherein the isolated dimethyl fumarate is characterized by XRPD peaks at 2-theta 10.9, 22.0, 24.0 and 27.3±0.2°.