IP Library › Granted Patent US 10,016,411
Granted Patent B2
US 10,016,411 · App. 15/026,579 · Granted Jul 10, 2018

Slow-release conjugates of SN-38

Inventors: Gary W. Ashley (Alameda, CA); Eric L. Schneider (Oakland, CA)
Assignee: ProLynx LLC
A61K31/4745A61K47/10A61K47/20A61K47/48215C07D457/00C07D491/22C07D519/00C08G65/48C08G83/002
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Quick Facts
Patent No.
US 10,016,411
App. No.
15/026,579
Granted
Jul 10, 2018
Kind
B2
Abstract

Conjugates of SN-38 that provide optimal drug release rates and minimize the formation of the corresponding glucuronate are described. The conjugates release SN-38 from a polyethylene glycol through a β-elimination mechanism.

Claims (5)

1. A conjugate having the formula

wherein m =1-6 and n is 200-250.

2. The conjugate of claim 1 wherein m is 1.

3. A pharmaceutical formulation comprising a conjugate of claim 1 together with a pharmaceutically acceptable excipient.

4. The formulation of claim 3 , wherein the pH of the formulation is between 4.0 and 6.0.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 14, 2016
From: ASHLEY, GARY; SCHNEIDER, ERIC L.
To: PROLYNX LLC
Reel/Frame 038907/0257 →
Continuity (2)
Provisional Application 61887111 · Oct 4, 2013
Related Publication 20160243106A1 · Aug 25, 2016
Cited By (1)
US 12,697,395