Microreactor system
A device and method for the individual dosing or drainage of small quantities of liquids or gases in microreactors and microreactor arrays, having a membrane and an outlet to a reaction chamber or a reactor arranged therebelow, which is surrounded by an area which forms a fluid line with the membrane, wherein the area or the membrane has an annular elevation which can be arranged around the outlet.
1. A microreactor system comprising:
(a) a reservoir;
(b) a valve comprising:
a base body having a top portion, a concave segment and an underside;
an outlet extending through the top portion of the base body and in fluid communication with the reservoir;
a membrane bearing against the underside of the base body;
an annular elevation disposed concentrically around the outlet and protruding from the concave segment toward the membrane, wherein the annual elevation is arcuate in section;
wherein the concave segment of the base body and the membrane define a hollow space in fluid communication with the outlet;
an outlet channel disposed between the underside of the base body and the membrane;
wherein the membrane is configured to bear against the annular elevation when under pneumatic or mechanical pressure, thereby sealing the valve; and
(c) a reaction chamber in fluid communication with the outlet channel of the valve.
2. The microreactor system according to claim 1 , wherein the concave segment of the base body comprises a depression constructed as a ball segment.
3. A fluid system comprising an array of microreactor systems according to claim 1 , wherein the membrane is a single membrane which covers the underside of each base body of each valve of the array of microreactor systems.
4. The fluid system according to claim 3 , further comprising a fluid system outlet arranged between an upper channel and a lower channel.
5. The fluid system according to claim 4 , wherein the upper channel, the lower channel and the fluid system outlet are arranged in a microfluidically structured plate.
6. The fluid system according to claim 3 , further comprising an actuator system comprising tappets or pneumatic lines acting on the membrane.
7. The fluid system according to claim 3 , wherein the membrane is arranged between a microfluidic chip having a top and bottom edge and a tray.
8. The fluid system according to claim 6 , wherein the actuator system is arranged on the membrane in a self-centering manner by aligning locking holes disposed in a microfluidic chip with corresponding pins disposed on a distributor strip.
9. The fluid system according to claim 6 , wherein the actuator system comprises a pneumatic system acting on the membrane.
10. The fluid system according to claim 3 , wherein each reservoir of the array of microreactor systems has a plurality of outlets.
11. The fluid system according to claim 3 , further comprising sensors located in the reaction chambers, wherein the sensors measure parameters in the reaction chambers and output the parameters to an online system, in order to act on an actuator system.
12. The fluid system according to claim 3 , further comprising an optical system.
13. The fluid system according to claim 3 , further comprising a shaker for moving the reaction chambers.
14. The fluid system according to claim 3 , wherein the plurality of outlets of the array of microreactor systems is arranged in such a manner that the plurality of outlets enable a pump function.
15. The fluid system according to claim 4 , wherein a liquid flow is on a plane and the array of microreactor systems change the plane of the liquid flow.
16. The fluid system according to claim 7 , wherein a plurality of valves of the array of microreactor systems are connected to one another.
17. The fluid system according to claim 3 , wherein the system comprises optically transparent materials.
18. The fluid system according to claim 16 , wherein the valves are arranged at the top edge of the microfluidic chip and allow optical access to the reaction chambers.
19. The fluid system according to claim 18 , further comprising a lid, wherein the system is self-centered on a bearing surface via locking holes and pins and by clamping down on the lid with force action.
20. The fluid system according to claim 6 , further comprising hydraulically actuated switches for controlling the valves.
21. The fluid system according to claim 6 , further comprising mechanically or electromagnetically actuated switches for controlling the valves.
22. The fluid system according to claim 3 , further comprising a clamping device configured to position and seal the system.
23. The fluid system according to claim 16 , wherein the valves connect the reservoirs to the reaction chambers.
24. The fluid system according to claim 3 , further comprising chemical or electrical sensors disposed in the reservoirs.
25. The fluid system according to claim 3 , wherein the reservoirs are pressure loaded.
26. The fluid system according to claim 23 , wherein a plurality of reservoirs open into the reaction chambers.
27. The fluid system according to claim 19 , wherein the lid is gas-permeable and covers the reaction chambers.
28. The fluid system according to claim 19 , further comprising a sterilization device for sterilizing the fluid system prior to use.
29. The fluid system according to claim 26 , wherein the reaction chambers and/or reservoirs can be refilled.
30. The fluid system according to claim 18 , further comprising a one-way valve feeding the reaction chambers.
31. The fluid system according to claim 16 , wherein a valve of the array of microreactor systems is connected upstream of a multiplicity of further valves of the array of microreactor systems and is used for multiplexing.
32. The fluid system according to claim 6 , wherein the actuator system is comprised as a connection strip comprising the tappets or pneumatic lines, and the fluid system further comprises a microtiter plate and a tensioning device.
33. The fluid system according to claim 32 , further comprising a gas supply system attached to the reaction chambers by at least one gas supply channel leading to at least one outlet hole in a lid.
34. The fluid system according to claim 7 , wherein a multiplicity of chemical, biochemical or biological reactions are controlled in the reaction chambers.
35. A method comprising:
providing a fluid system comprising an array of microreactor systems according to claim 1 ;
introducing a controlled liquid and/or gas supply into the fluid system;
using the valves to convey the controlled liquid and/or gas through the fluid system; and
using the fluid system for opening and closing the valves between reaction chambers of the array of microreactor systems.
36. A method comprising:
providing a fluid system comprising an array of microreactor systems according to claim 1 ;
introducing a controlled liquid and/or gas supply in the fluid system;
using the valves to convey the controlled liquid and/or gas through the fluid system; and
using the fluid system for pumping fluid out of a reservoir and into a reaction chamber of the array of microreactor systems.