IP Library › Granted Patent US 10,077,294
Granted Patent B2
US 10,077,294 · App. 15/031,754 · Granted Sep 18, 2018

Peptide inhibitors of TEAD/YAP-TAZ interaction

Inventors: Angelita Rebollo Garcia (Paris, FR); Fariba Nemati (Paris, FR); Didier Decaudin (Verrieres le Buisson, FR)
Assignees: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6); INSTITUT CURIE
C07K14/4703C07K7/08A61K38/00C07K2319/10C07K2319/23
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 10,077,294
App. No.
15/031,754
Granted
Sep 18, 2018
Kind
B2
Abstract

The invention relates to an isolated peptide inhibitor of the interaction between the TEAD and YAP or TAZ proteins and a derived chimeric peptide linked to a cell-penetrating peptide. These peptides which have a cytotoxic activity are useful, in particular for the treatment of hyperproliferative disorders such as cancer.

Claims (2)

1. A chimeric peptide, which comprises or consists of an amino acid sequence selected from SEQ ID NO: 35, SEQ ID NO: 36, SEQ NO: 37, and SEQ ID NO: 39.

2. A pharmaceutical composition comprising the chimeric peptide of claim 1 .

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 18, 2016
From: REBOLLO GARCIA, ANGELITA; NEMATI, FARIBA; DECAUDIN, DIDIER
To: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6); INSTITUT CURIE
Reel/Frame 039180/0515 →
Priority Claims (1)
EP 13306512 · Nov 4, 2013 · regional
Continuity (1)
Related Publication 20160264636A1 · Sep 15, 2016