Compositions and methods for modulating neuronal excitability and motor behavior
The invention is directed to compositions and methods for treating or reducing the likelihood of the development of epilepsy in an individual. The method comprises administering to the central nervous system of an individual in need of such treatment a therapeutically effective amount of an agent capable of increasing the expression and/or activity of miR-128.
1. A method for treating or reducing the likelihood of the development or occurrence of seizures in an individual with Dravet Syndrome, comprising administering to said individual a therapeutically effective amount of microRNA-128 (miR-128) having the nucleotide sequence of SEQ ID NO: 1.
2. The method of claim 1 , wherein the agent is administered intrathecally or intranasally.
3. A method for treating or reducing the likelihood of the development or occurrence of seizures in an individual who has suffered a brain injury caused by stroke comprising administering to said individual a therapeutically effective amount of miR-128 having the nucleotide sequence of SEQ ID NO: 1.