Process of chiral resolution of cyclic and acyclic acetates to enantiomerically pure (R)-alcohols
The patent discloses herein a process for the chiral resolution of racemic cyclic and acyclic acetates to obtain (R)-alcohol. Further, it discloses the resolution of racemic cyclic and acyclic acetates to obtain enantiomerically pure (R)-(−)-alcohol as single enantiomer through fungal catalyzed deacylation in single fermentation, wherein fungal strains are F. proliferatum.
1. A process for chiral resolution of a racemic acetate to obtain an enantiomerically pure (R)-Alcohol as a single enantiomer comprising the steps of:
i) incubating Fusarium proliferatum for from 24 to 48 hours at a temperature between 28° C. to 30° C. in a medium;
ii) adding the racemic acetate to the medium after step i) and incubating further for from 6 hours to 3 days at temperature between 28° C. to 30° C. to obtain the enantiomerically pure (R)-Alcohol.
2. The process according to claim 1 , wherein the Fusarium proliferatum comprises spores and mycelia.
3. The process according to claim 1 , wherein the racemic acetate is selected from the group consisting of 2-Heptyl acetate, lavandulyl acetate and 2-Hexyl acetate.
4. The process according to claim 1 , wherein the racemic acetate is a cyclic racemic acetate or an acyclic racemic acetate.
5. The process according to claim 1 , wherein a yield of the enantiomerically pure (R)-Alcohol as a single enantiomer is 95-99.9%.
6. The process according to claim 1 , wherein the enantiomerically pure (R)-Alcohol is selected from the group consisting of R-lavandulol, R-2-Hexnol, R-2-Heptanol, R-1-Phenyl ethanol and R-1-Phenyl propanol.