Granted Patent
B2
US 10,351,590 · App. 15/038,927 · Granted Jul 16, 2019
Withanolides useful for the treatment of neurodegenerative diseases
Inventors:
Anthony A. Shaw (Vancouver, CA); Jean-Pierre Julien (Quebec, CA); Agnes H. Chan (Vancouver, CA)
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Abstract
Provided herein are synthetic analogs of withanolide natural products of formula (I), wherein R1-R4 are as defined herein, and their pharmaceutical uses in treating neurodegenerative diseases.
Claims (9)
1. A compound having a structure represented by Formula (Ia):
wherein:
R 1 is hydrogen, or methyl; and
R 3 is hydrogen, or methyl,
wherein, R 1 and R 3 cannot both be hydrogen.
2. The compound of claim 1 wherein R 1 is methyl and R 3 is hydrogen.
3. The compound of claim 1 wherein R 1 is hydrogen and R 3 is methyl.
4. The compound of claim 1 wherein R 1 is methyl and R 3 is methyl.
5. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable excipient.
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 12, 2017
From: SHAW, ANTHONY A.; CHAN, AGNES H.
To: IMSTAR THERAPEUTICS INC.
Reel/Frame 040958/0235 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 12, 2017
From: JULIEN, JEAN-PIERRE
To: UNIVERSITE LAVAL
Reel/Frame 040958/0816 →
Continuity (2)
Provisional Application
61908455
· Nov 25, 2013