Adenylyl cyclase inhibitors for neuropathic and inflammatory pain
The invention generally relates to adenylyl cyclase inhibitor compounds and methods for treating neuropathic or inflammatory pain by using those compounds.
1. A compound of formula (I):
wherein:
X is nitrogen;
n is 1;
R 1 is an alkyl substituted by a fused heterocycloalkenyl, wherein said fused heterocycloalkenyl is substituted at the heteroatom by alkyl, wherein said fused heterocycloalkenyl is
R 2 is a branched or unbranched alkyl substituted by aryl, wherein the aryl is optionally substituted by halo, NO 2 , or alkoxy, wherein said aryl is phenyl;
R 3 is
wherein Ar is phenyl optionally substituted at any ring position by alkyl, halo, COOR 4 , NO 2 , alkoxy, OOR 4 , or haloalkyl; and
R 4 is alkyl.
2. A compound of formula (I):
wherein:
X is nitrogen;
n is 1;
R 1 is an alkyl substituted by a fused heterocycloalkenyl, wherein said fused heterocycloalkenyl is
R 2 is a branched or unbranched alkyl substituted by aryl, wherein the aryl is optionally substituted by halo, NO 2 , or alkoxy, wherein said aryl is phenyl; and
R 3 is
wherein Ar is phenyl substituted by iodine, chlorine, bromine, or COOR 6 , wherein R 6 is alkyl.
3. A method of treating neuropathic or inflammatory pain, the method comprising administering a pharmaceutical composition comprising a compound of formula (I) and a pharmaceutically acceptable carrier to a patient:
wherein:
X is nitrogen;
n is 1;
R 1 is an alkyl substituted by an indolyl, wherein the nitrogen of the indolyl is optionally substituted by alkyl;
R 2 is an alkyl substituted by aryl, wherein the aryl is optionally substituted by halo, NO 2 , or alkoxy, wherein said aryl is phenyl or naphthyl; and
R 3 is
wherein Ar is a phenyl optionally substituted at any ring position by alkyl, halo, COOR 4 , NO 2 , alkoxy, OOR 4 , or haloalkyl; and
R 4 is alkyl.